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Mauri Laakso
University of Oulu
EndocrinologyInsulinDiabetes mellitusMedicineBiology
1,012Publications
139H-index
113kCitations
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Publications 873
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#1Naeimeh Atabaki-Pasdar (Lund University)H-Index: 3
#2Mattias Ohlsson (Halmstad University)H-Index: 27
Last. Azra Kurbasic (Lund University)H-Index: 6
view all 63 authors...
Background Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes serious health complications in individuals with and without type 2 diabetes (T2D). Early diagnosis of NAFLD is important, as this can help prevent irreversible damage to the liver and, ultimately, hepatocellular carcinomas. We sought to expand etiological understanding and develop a diagnostic tool for NAFLD using machine learning. Methods and findings We utilized the baseline data from IMI DIRECT, a multicenter...
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#1Fumiaki Imamura (University of Cambridge)H-Index: 27
#2Amanda M. Fretts (UW: University of Washington)H-Index: 18
Last. Jyrki K. Virtanen (University of Eastern Finland)H-Index: 32
view all 52 authors...
Background De novo lipogenesis (DNL) is the primary metabolic pathway synthesizing fatty acids from carbohydrates, protein, or alcohol. Our aim was to examine associations of in vivo levels of selected fatty acids (16:0, 16:1n7, 18:0, 18:1n9) in DNL with incidence of type 2 diabetes (T2D). Methods and findings Seventeen cohorts from 12 countries (7 from Europe, 7 from the United States, 1 from Australia, 1 from Taiwan; baseline years = 1970–1973 to 2006–2010) conducted harmonized individual-leve...
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#1Yu JiangH-Index: 4
#2Sai ChenH-Index: 4
Last. Kevin LiH-Index: 4
view all 20 authors...
There is great interest in understanding the impact of rare variants in human diseases using large sequence datasets. In deep sequence datasets of >10,000 samples, ~10% of the variant sites are observed to be multi-allelic. Many of the multi-allelic variants have been shown to be functional and disease-relevant. Proper analysis of multi-allelic variants is critical to the success of a sequencing study, but existing methods do not properly handle multi-allelic variants and can produce highly misl...
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#1Selina Mäkinen (UH: University of Helsinki)H-Index: 2
#2Neeta Datta-Sengupta (UH: University of Helsinki)
Last. Heikki A. Koistinen (UH: University of Helsinki)H-Index: 32
view all 6 authors...
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#1Naeimeh Atabaki-Pasdar (Lund University)H-Index: 3
#2Mattias Ohlsson (Lund University)H-Index: 27
Last. Azra Kurbasic (Lund University)H-Index: 6
view all 63 authors...
Background: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes serious health complications in type 2 diabetes (T2D) and beyond. Early diagnosis of NAFLD is important, as this can help prevent irreversible damage to the liver and ultimately hepatocellular carcinomas. Methods and Findings: Utilizing the baseline data from the IMI DIRECT participants (n=1514) we sought to expand etiological understanding and develop a diagnostic tool for NAFLD using machine learning. Multi-om...
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Last. Johanna KuusistoH-Index: 85
view all 10 authors...
Objective To investigate whether the Ala143Thr variant of the α-galactosidase A gene (A143T/GLA), with conflicting interpretations of pathogenicity, is associated with Fabry cardiomyopathy. Methods The index patient, a woman in her 60s with cardiomyopathy, was screened for variants in 59 cardiomyopathy-related genes. A143T/GLA, the only rare variant found, was screened in 10 relatives. GLA activity and lyso-Gb3 levels were measured and echocardiography was performed in 8 of 9 subjects carrying A...
3 CitationsSource
#1Adam E. Locke (UM: University of Michigan)H-Index: 25
#2Karyn Meltz Steinberg (WashU: Washington University in St. Louis)H-Index: 17
Last. Nelson B. Freimer (Semel Institute for Neuroscience and Human Behavior)H-Index: 81
view all 41 authors...
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