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Rinse K. Weersma
University Medical Center Groningen
259Publications
50H-index
14.8kCitations
Publications 259
Newest
#1Floris Imhann (UMCG: University Medical Center Groningen)H-Index: 8
#2K. van der Velde (UMCG: University Medical Center Groningen)H-Index: 1
Last.Rinse K. Weersma (UMCG: University Medical Center Groningen)H-Index: 50
view all 16 authors...
Inflammatory bowel disease (IBD) is a chronic complex disease of the gastrointestinal tract. Patients with IBD can experience a wide range of symptoms, but the pathophysiological mechanisms that cause these individual differences in clinical presentation remain largely unknown. In consequence, IBD is currently classified into subtypes using clinical characteristics. If we are to develop a more targeted treatment approach, molecular subtypes of IBD need to be discovered that can be used as new dr...
#1Floris Imhann (UMCG: University Medical Center Groningen)H-Index: 8
#2K. van der Velde (UMCG: University Medical Center Groningen)H-Index: 1
Last.Rinse K. Weersma (UMCG: University Medical Center Groningen)H-Index: 50
view all 16 authors...
#1Joëlle C. Schutten (UMCG: University Medical Center Groningen)H-Index: 2
#2Peter J. Joris (UM: Maastricht University)H-Index: 8
Last.Stephan J. L. Bakker (UMCG: University Medical Center Groningen)H-Index: 68
view all 10 authors...
Background Arterial stiffness is closely related to the process of atherosclerosis, an independent cardiovascular risk factor, and predictive of future cardiovascular events and mortality. Recently, we showed that magnesium citrate supplementation results in a clinically relevant improvement of arterial stiffness. It remained unclear whether the observed effect was due to magnesium or citrate, and whether other magnesium compounds may have similar effects. Therefore, we aim to study the long-ter...
#1Marjolein A Y Klaassen (UMCG: University Medical Center Groningen)
#2Floris Imhann (UMCG: University Medical Center Groningen)H-Index: 8
Last.Rinse K. Weersma (UMCG: University Medical Center Groningen)H-Index: 50
view all 11 authors...
Inflammatory bowel disease (IBD) is a chronic and heterogeneous intestinal inflammatory disorder. The medical management of IBD aims for long-lasting disease remission to prevent complications and disease progression. Early introduction of immunosuppression forms the mainstay of medical IBD management. Large inter-individual variability in drug responses, in terms of both efficacy and toxicity, leads to high rates of therapeutic failure in the management of IBD. Better patient stratification is ...
#1Trishla Sinha (UMCG: University Medical Center Groningen)H-Index: 1
#2Arnau Vich Vila (UMCG: University Medical Center Groningen)H-Index: 11
Last.Alexandra ZhernakovaH-Index: 53
view all 17 authors...
ABSTRACTSeveral gastrointestinal diseases show a sex imbalance, although the underlying (patho)physiological mechanisms behind this are not well understood. The gut microbiome may be involved in this process, forming a complex interaction with host immune system, sex hormones, medication and other environmental factors. Here we performed sex-specific analyses of fecal microbiota composition in 1135 individuals from a population-based cohort. The overall gut microbiome composition of females and ...
#1Rinse K. Weersma (UMCG: University Medical Center Groningen)H-Index: 50
#2Miles ParkesH-Index: 48
The last decade has seen an explosion in genome-wide association studies (GWAS) in many diseases. With these—and its worth reminding ourselves that this is the primary goal of GWAS—have come valuable insights into pathogenic pathways. Some have been predictable (eg, variants affecting antigen presentation, co-stimulation and T-cell responses in immune-mediated diseases) and others, unexpected (eg, autophagy in Crohn’s disease). Until recently, such studies were performed in disease cohorts speci...
#1Eric A. Franzosa (Broad Institute)H-Index: 27
#2Alexandra Sirota-Madi (Broad Institute)H-Index: 6
Last.Ramnik J. Xavier (MIT: Massachusetts Institute of Technology)H-Index: 107
view all 27 authors...
In the Supplementary Tables 2, 4 and 6 originally published with this Article, the authors mistakenly included sample identifiers in the form of UMCGs rather than UMCG IBDs in the validation cohort; this has now been amended.
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