Anton W. Langerak
Erasmus University Rotterdam
Molecular biologyImmunologyCancer researchMedicineBiology
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Publications 293
#1Frederic Davi (University of Paris)H-Index: 48
#2Anton W. Langerak (EUR: Erasmus University Rotterdam)H-Index: 53
Last. Paolo Ghia (UniSR: Vita-Salute San Raffaele University)H-Index: 59
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Twenty years after landmark publications, there is a consensus that the somatic hypermutation (SHM) status of the clonotypic immunoglobulin heavy variable (IGHV) gene is an important cornerstone for accurate risk stratification and therapeutic decision-making in patients with chronic lymphocytic leukemia (CLL). The IGHV SHM status has traditionally been determined by conventional Sanger sequencing. However, NGS has heralded a new era in medical diagnostics and immunogenetic analysis is following...
#1Fabian M.P. KaiserH-Index: 1
#2Ismail ReisliH-Index: 25
Last. Mirjam van der Burg (LUMC: Leiden University Medical Center)H-Index: 5
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CAPSULE SUMMARY: Somatic revertants frequently occur in the slipstream of pathogenic germline mutations, but protein functionality may act as a bottleneck in the selection for functional variants.
#1Narissara Suratannon (Chula: Chulalongkorn University)H-Index: 6
#2Rogier T. A. van Wijck (EUR: Erasmus University Rotterdam)
Last. Anton W. Langerak (EUR: Erasmus University Rotterdam)H-Index: 53
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Background: Genetic tests for primary immunodeficiency disorders (PIDs) are expensive, time-consuming, and not easily accessible in developing countries. Therefore, we studied the feasibility of a customized single nucleotide variant (SNV) microarray that we developed to detect disease-causing variants and copy number variation (CNV) in patients with PIDs for only 40 Euros. Methods: Probes were custom-designed to genotype 9,415 variants of 277 PID-related genes, and were added to the genome-wide...
#1Patricia J. T. A. Groenen (Radboud University Nijmegen)H-Index: 36
#2Anton W. Langerak (EUR: Erasmus University Rotterdam)H-Index: 53
Last. J.H.J.M. van Krieken (Radboud University Nijmegen)H-Index: 62
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The vast increase of technical, diagnostic, and treatment possibilities and deepened understanding of molecular biology has revolutionized diagnosis and treatment of cancer and thus has great impact on pathology. Different professionals are responsible for proper evaluation of the results and their translating into an accurate diagnosis and appropriate treatment. Next to expertise, a close interaction between clinical molecular biologists, pathologists, and oncologists is required; it is crucial...
#1Michiel G.H. Betjes (EUR: Erasmus University Rotterdam)H-Index: 39
#2Anton W. Langerak (EUR: Erasmus University Rotterdam)H-Index: 53
Last. Nicolle H.R. Litjens (EUR: Erasmus University Rotterdam)H-Index: 22
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Background: End-stage renal disease is associated with premature ageing of the T cell immune system but inter-individual variation is substantial. The hypothesis was tested that advanced immunological T cell ageing assessed by peripheral T cell differentiation increases the long-term mortality risk after renal transplantation. Results: Circulating T cells of 211 recipients of a kidney from a living donor were analyzed before and in the first year after transplantation. The number of CD31-positiv...
2 CitationsSource
#1Anton W. Langerak (EUR: Erasmus University Rotterdam)H-Index: 53
#2Frederic Davi (University of Paris)H-Index: 48
Last. Kostas StamatopoulosH-Index: 30
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1 CitationsSource
#1Simar Pal Singh (EUR: Erasmus University Rotterdam)H-Index: 5
#2Marjolein J. W. de Bruijn (EUR: Erasmus University Rotterdam)H-Index: 16
Last. Rudi W. HendriksH-Index: 48
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Balanced activity of kinases and phosphatases downstream of the BCR is essential for B cell differentiation and function and is disturbed in chronic lymphocytic leukemia (CLL). In this study, we employed IgH.TEμ mice, which spontaneously develop CLL, and stable EMC CLL cell lines derived from these mice to explore the role of phosphatases in CLL. Genome-wide expression profiling comparing IgH.TEμ CLL cells with wild-type splenic B cells identified 96 differentially expressed phosphatase genes, i...
1 CitationsSource
#1Ruud W. J. Meijers (EUR: Erasmus University Rotterdam)H-Index: 10
#2Alice F. Muggen (EUR: Erasmus University Rotterdam)H-Index: 6
Last. Anton W. Langerak (EUR: Erasmus University Rotterdam)H-Index: 53
view all 7 authors...
Chronic lymphocytic leukemia is a heterogeneous disease based on clinical and biological characteristics. Differences in Ca2+-levels among cases, both basal and upon B-cell receptor stimulation may reflect heterogeneity in the pathogenesis due to cell-intrinsic factors. Our aim is to elucidate cell-intrinsic differences between B-cell receptor responsive and unresponsive cases. Therefore the B-cell receptor responsiveness was determined ex vivo based on Ca2+-influx upon α-IgM stimulation of puri...
1 CitationsSource
#1Kirsten Fischer (University of Bonn)H-Index: 31
#2Matthias Ritgen (CAU: University of Kiel)H-Index: 34
Last. Michael Hallek (University of Cologne)H-Index: 95
view all 21 authors...
DISCLOSURES: Fischer: Roche: Other: travel grants; AbbVie: Honoraria, Membership on an entity's Board of Directors or advisory committees. Ritgen:AbbVie: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; BMS: Membership on an entity's Board of Directors or advisory committees; Roche: Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: travel support, Research Funding. Al-Sawaf:Gilead: Honoraria, Membership on an e...
3 CitationsSource
#1Arnon P. Kater (UvA: University of Amsterdam)H-Index: 34
Last. Anton W. Langerak (EUR: Erasmus University Rotterdam)H-Index: 53
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1 CitationsSource