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Lik Voon Kiew
University of Malaya
ChemistryIn vivoPhotodynamic therapyBiochemistryPharmacology
36Publications
11H-index
1,241Citations
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Publications 38
Newest
#1Shie Yin NgH-Index: 2
#2Anyanee Kamkaew (Suranaree University of Technology)H-Index: 2
Last. Hong Boon LeeH-Index: 10
view all 9 authors...
Abstract Active targeting compound, a non-iodinated derivative of IK-IK-I2-azaBODIPY (1a) was previously reported to preferentially bind melanoma over healthy cells. In this study, we evaluate the photodynamic therapy (PDT) efficiency on melanoma cells of 1a, together with its reversed sequence compound KI-KI-I2-azaBODIPY (1b) and a non-targeted control I2-azaBODIPY-NH2 (2). All three test compounds possess absorption wavelengths in the near-infrared (NIR) region (λmax between 678 and 687 nm) wh...
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#1Theebaa Anasamy (UM: University of Malaya)H-Index: 5
#2Chin Fei Chee (UM: University of Malaya)H-Index: 10
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
view all 4 authors...
Abstract This study reports the in vivo performance of two tribenzyltin carboxylate complexes, tri(4-fluorobenzyl)tin[(N,N-diisopropylcarbamothioyl)sulfanyl]acetate (C1) and tribenzyltin isonicotinate (C9), in their native form as well as in a poly(lactic-co-glycolic acid) (PLGA)-based nanoformulation, to assess their potential to be translated into clinically useful agents. In a 4T1 murine metastatic mammary tumour model, single intravenous administration of C1 (2.7 mg/kg) and C9 (2.1 mg/kg; 2....
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#1Nur ‘Afina Rusdi (Management and Science University)
#2Chin Siang Kue (Management and Science University)H-Index: 4
Last. Lik Voon Kiew (UM: University of Malaya)H-Index: 11
view all 6 authors...
Despite the extensive work on anticancer drug discovery, the number of potent lead compounds that enter the preclinical and clinical trials thus far is still low due to the poor selectivity and und...
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#1Laura Chambre (Boğaziçi University)H-Index: 2
#2Wen Shang SawH-Index: 3
Last. Amitav Sanyal (Boğaziçi University)H-Index: 25
view all 10 authors...
Photosensitizing nanogels were obtained through a surfactant-free single-step protocol by using a porphyrin-based cross-linker for stabilizing self-assembled nanosized aggregates of thermoresponsive copolymers. Nanogels with varying amounts of porphyrin retained the singlet oxygen generation ability of the porphyrin core and were also capable of inducing temperature increase upon irradiation at 635 nm. Photoinduced killing efficiency was tested against three cell lines: human breast adenocarcino...
1 CitationsSource
#1Chin Siang Kue (Management and Science University)H-Index: 4
#2Shie Yin Ng (UM: University of Malaya)H-Index: 2
Last. Hong Boon Lee (UM: University of Malaya)H-Index: 7
view all 7 authors...
BODIPYs are photosensitizers activatable by light to generate highly reactive singlet oxygen (1O2) from molecular oxygen, leading to tissue damage in the photoirradiated region. Despite their extraordinary photophysical characteristics, they are not featured in clinical photodynamic therapy. This review discusses the recent advances in the design and/or modifications of BODIPYs since 2013, to improve their potential in photodynamic cancer therapy and related areas.
16 CitationsSource
#1Ampornphan Siriviriyanun (NTUST: National Taiwan University of Science and Technology)H-Index: 6
#2Ya-Ju Tsai (NTUST: National Taiwan University of Science and Technology)H-Index: 2
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
view all 10 authors...
Abstract In this study, nanohybrid materials consisting of graphene oxide (GO), β‑cyclodextrin (CD) and poly(amido amine) dendrimer (DEN) were successfully prepared by covalent bonding. GO-CD and GO-CD-DEN were found to be potential nanocarriers for anticancer drugs including chemotherapeutics (doxorubicin (DOX), camptothecin (CPT)) and photosensitizer (protoporphyrin IX (PpIX)). GO-CD possessed 1.2 times higher DOX-loading capacity than GO due to inclusion of additional DOX to the CD. The drug ...
6 CitationsSource
#1Hoay Yan CheahH-Index: 3
#2Elena GallonH-Index: 5
Last. Lik Voon KiewH-Index: 11
view all 11 authors...
We previously developed a new zinc(II) phthalocyanine (ZnPc) derivative (Pc 1) conjugated to poly-L-glutamic acid (PGA) (1-PG) to address the limitations of ZnPc as part of an antitumor photodynamic therapy approach, which include hydrophobicity, phototoxicity, and nonselectivity in biodistribution and tumor targeting. During this study, we discovered that 1-PG possessed high near-infrared (NIR) light absorptivity (λmax = 675 nm), good singlet oxygen generation efficiency in an aqueous environme...
2 CitationsSource
#1Wen Shang Saw (UM: University of Malaya)H-Index: 3
#2Masaki Ujihara (NTUST: National Taiwan University of Science and Technology)H-Index: 8
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
view all 9 authors...
Abstract Physiochemical changes, including size, are known to affect gold nanoparticle cellular internalization and treatment efficacy. Here, we report the effect of four sizes of cystine/citric acid-coated confeito-like gold nanoparticles (confeito-AuNPs) (30, 60, 80 and 100 nm) on cellular uptake, intracellular localization and photothermal anticancer treatment efficiency in MDA-MB231 breast cancer cells. Cellular uptake is size dependent with the smallest size of confeito-AuNPs (30 nm) having...
11 CitationsSource
#1Siaw Fui Kiew (UM: University of Malaya)H-Index: 3
#2Yan Teck Ho (NUS: National University of Singapore)H-Index: 4
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
view all 7 authors...
We synthesized a dextrin (DEX)-conjugated graphene oxide (GO) nanocarrier (GO 100 -DEX) as a potential drug delivery system to respond to a tumor-associated stimulus, α-amylase, that has high permeability through the fenestrated endothelial barrier to the tumor site. At acidic pH and in the presence of α-amylase to simulate tumor conditions, GO 100 -DEX released a 1.5-fold higher amount of doxorubicin (DOX) than of GO 100 . Under the same conditions, the cytotoxic effects of GO 100 -DEX/DOX were...
3 CitationsSource
#1Siew Hui Voon (UM: University of Malaya)H-Index: 6
#2Chin Siang Kue (UM: University of Malaya)H-Index: 4
Last. Shin-ichi Yusa (University of Hyogo)H-Index: 29
view all 8 authors...
Abstract Previously reported amphiphilic diblock copolymer with pendant dendron moieties (P 71 D 3 ) has been further evaluated in tumor-bearing mice as a potential drug carrier. This P 71 D 3 -based micelle of an average diameter of 100 nm was found to be biocompatible, non-toxic and physically stable in colloidal system up to 15 days. It enhanced the in vitro potency of doxorubicin (DOX) in 4T1 breast tumor cells by increasing its uptake, by 3-fold, compared to free DOX. In 4T1 tumor-bearing m...
3 CitationsSource
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