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Charumathi Sabanayagam
National University of Singapore
208Publications
30H-index
5,544Citations
Publications 208
Newest
Published on Apr 10, 2019
Daniel Shu Wei Ting8
Estimated H-index: 8
(NUS: National University of Singapore),
Daniel S. W. Ting (NUS: National University of Singapore)+ 14 AuthorsLéopold Simar74
Estimated H-index: 74
In any community, the key to understanding the burden of a specific condition is to conduct an epidemiological study. The deep learning system (DLS) recently showed promising diagnostic performance for diabetic retinopathy (DR). This study aims to use DLS as the grading tool, instead of human assessors, to determine the prevalence and the systemic cardiovascular risk factors for DR on fundus photographs, in patients with diabetes. This is a multi-ethnic (5 races), multi-site (8 datasets from Sin...
Published on May 1, 2019in American Journal of Ophthalmology 4.48
Tien Wong121
Estimated H-index: 121
(NUS: National University of Singapore),
Yih-Chung Tham8
Estimated H-index: 8
(NUS: National University of Singapore)
+ 1 AuthorsChing-Yu Cheng47
Estimated H-index: 47
(NUS: National University of Singapore)
Abstract Purpose To describe the pattern and risk factor traits associated with visual loss (defined as either visual impairment[VI] or blindness) in a multi-ethnic Asian cohort of Malays, Indians and Chinese living in Singapore. Methods 10,020 participants from the Singapore Epidemiology of Eye Diseases (SEED) Study were examined between 2004-2011. All underwent standardized examinations. VI [VA Results Malays had higher age-standardised prevalence of best-corrected and presenting VI (5.4%; 19....
Published in British Journal of Ophthalmology 3.62
Shivani Majithia1
Estimated H-index: 1
,
Yih Chung Tham10
Estimated H-index: 10
+ -3 AuthorsTien Wong121
Estimated H-index: 121
Background/aims In order to address the eye care needs of the increasing numbers of elderly Chinese globally, there is a need for comprehensive understanding on the longitudinal trends of age-related eye diseases among Chinese. We herein report the key findings from the baseline Singapore Chinese Eye Study (SCES-1), and describe the rationale and methodology of the 6-year follow-up study (SCES-2). Methods 3353 Chinese adults who participated in the baseline SCES-1 (2009–2011) were invited for th...
Published on Apr 10, 2019in Human Molecular Genetics 4.54
Yun Ju Sung17
Estimated H-index: 17
(WashU: Washington University in St. Louis),
Yun J. Sung7
Estimated H-index: 7
(WashU: Washington University in St. Louis)
+ 278 AuthorsHelen R. Warren19
Estimated H-index: 19
(QMUL: Queen Mary University of London)
Published on Aug 10, 2018in British Journal of Ophthalmology 3.62
Kah Hie Wong1
Estimated H-index: 1
,
Yih-Chung Tham8
Estimated H-index: 8
+ 9 AuthorsLéopold Simar74
Estimated H-index: 74
Aim To evaluate racial differences, and ocular and systemic determinants of macular thickness (MT), measured by spectral-domain optical coherence tomography (SD-OCT) in a normal multiethnic Asian population. Method MT was measured from a 6×6 mm 2 central macular area using the Cirrus high-definition OCT (HD-OCT) (Carl Zeiss Meditec, Dublin, CA). The associations between ocular and systemic factors with MT were evaluated using linear regression analyses with generalised estimating equation models...
Published on Jun 28, 2019in bioRxiv
Cassandra N. Spracklen10
Estimated H-index: 10
(UNC: University of North Carolina at Chapel Hill),
Momoko Horikoshi30
Estimated H-index: 30
+ 108 AuthorsSoo-Heon Kwak (Seoul National University Hospital)
Meta-analyses of genome-wide association studies (GWAS) have identified >240 loci associated with type 2 diabetes (T2D), however most loci have been identified in analyses of European-ancestry individuals. To examine T2D risk in East Asian individuals, we meta-analyzed GWAS data in 77,418 cases and 356,122 controls. In the main analysis, we identified 298 distinct association signals at 178 loci, and across T2D association models with and without consideration of body mass index and sex, we iden...
Published on Jun 1, 2019in American Journal of Kidney Diseases 6.65
Simon Nusinovici , Charumathi Sabanayagam30
Estimated H-index: 30
(NUS: National University of Singapore)
+ 2 AuthorsTien Wong121
Estimated H-index: 121
(NUS: National University of Singapore)
Eyes and kidneys have numerous structural, developmental, physiologic, and pathogenic pathways in common, suggesting that many kidney and eye diseases may be interlinked. Studies suggest that the prevalence of eye diseases and vision impairment are higher among persons with end-stage kidney disease and earlier stages of chronic kidney disease (CKD) than in those without. Ocular morbidity in persons with CKD and end-stage kidney disease may be due to the following risk factors: (1) underlying con...
Published on May 1, 2019in American Journal of Ophthalmology 4.48
Ryan Ek Man2
Estimated H-index: 2
,
Alfred Tl Gan1
Estimated H-index: 1
+ 7 AuthorsEcosse L. Lamoureux41
Estimated H-index: 41
ABSTRACT Purpose To determine the association of refractive error (RE) and its associated determinants (axial length [AL], anterior chamber depth (ACD) and corneal curvature [CC]) with the incidence and progression of diabetic retinopathy (DR). Design Population-based cohort study Methods A total of 1562 eyes of 840 individuals with diabetes and gradable retinal photographs (mean age [SD]: 57.0 [8.3] years, 48.2% female), from the Singapore Malay and Indian Eye Studies, at baseline (2004-2009) a...
Published on May 1, 2019in Investigative Ophthalmology & Visual Science 3.81
Elizabeth Wen Ling Lim (NUS: National University of Singapore), Miao Li Chee3
Estimated H-index: 3
+ 5 AuthorsLouis Tong34
Estimated H-index: 34
Published on Mar 29, 2019
Charumathi Sabanayagam30
Estimated H-index: 30
(Visual Sciences),
Charumathi Sabanayagam (Visual Sciences)+ 5 AuthorsTien Wong121
Estimated H-index: 121
(Visual Sciences)
Importance The association of diabetic microvascular complications such as diabetic retinopathy (DR) and diabetic kidney disease (DKD) with mortality in populations is not clear. Objective To examine the association of DR and DKD separately and jointly with all-cause and cardiovascular disease (CVD) mortality in a multiethnic Asian population. Design, Setting, and Participants A population-based cohort study was conducted including 2964 adults between the ages of 40 and 80 years with diabetes wh...
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