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Gregory B. Lesinski
Emory University
CancerImmunologyCancer researchMedicineBiology
163Publications
29H-index
2,384Citations
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Publications 178
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#1Ganji Purnachandra Nagaraju (Emory University)H-Index: 21
#2Batoul Farran (Emory University)H-Index: 3
Last. Bassel F. El-Rayes (Emory University)H-Index: 29
view all 7 authors...
BACKGROUND: The induction of reactive oxygen species (ROS) represents a viable strategy for enhancing the activity of radiotherapy. The authors hypothesized that napabucasin would increase ROS via its ability to inhibit NAD(P)H:quinone oxidoreductase 1 and potentiate the response to chemoradiotherapy in rectal cancer via distinct mechanisms. METHOD: Proliferation studies, colony formation assays, and ROS levels were measured in HCT116 and HT29 cell lines treated with napabucasin, chemoradiation,...
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#1Ibrahim Halil Sahin (Emory University)H-Index: 5
#2Sujata R. Kane (Emory University)H-Index: 1
Last. Bassel F. El-Rayes (Emory University)H-Index: 29
view all 9 authors...
Recent studies have identified durable responses with the use of immune checkpoint inhibitors in patients with mismatch repair–deficient (MMR-D)/microsatellite instability–high (MSI-H) metastatic c...
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#1Lacey A Perdue (Georgia Institute of Technology)
#2Priscilla Do (Georgia Institute of Technology)
Last. Christopher C. Porter (Emory University)H-Index: 18
view all 11 authors...
Cytokine signaling is challenging to study and therapeutically exploit as the effects of these protein are often pleiotropic. A subset of cytokines can, however, exert signal specificity via association with latency-inducing proteins which cage the cytokine until disrupted by discreet biological stimuli. Inspired by this precision, here we describe a strategy for synthetic induction of cytokine latency via modification with photo-labile polymers that mimic latency while attached, then restore pr...
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#1Michael B. Ware (Emory University)H-Index: 1
#2Christopher McQuinn (OSU: Ohio State University)H-Index: 3
Last. Jacob S. Bowers (MUSC: Medical University of South Carolina)H-Index: 8
view all 17 authors...
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is exceptionally resistant to immune checkpoint inhibition (ICI). We previously reported that elevated systemic interleukin-6 (IL-6) and increased numbers of T cells positive for circulating cytotoxic T-lymphocyte-associated protein 4 (CTLA 4) correlate with worse overall survival in patients with PDAC. We postulated that combined blockade of IL-6 and CTLA-4 would significantly enhance anti-tumor immune responses to PDAC. Dual blockade of IL-6 an...
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#2Subir Goyal (Emory University)H-Index: 1
Last. Walid L. Shaib (Emory University)H-Index: 12
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225Background: ICIs induce durable responses in dMMR CRC patients. However, clinical and molecular biomarkers of response to ICIs have not been well-established. In this study, we investigated impa...
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#1Olatunji B. AleseH-Index: 9
#2Walid L. Shaib (Emory University)H-Index: 12
Last. Bassel F. El-Rayes (Emory University)H-Index: 29
view all 6 authors...
TPS269Background: Panitumumab (Pmab) is a recombinant monoclonal antibody that binds specifically to the human epidermal growth factor receptor (EGFR), and is indicated for metastatic colorectal ca...
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#1Mehmet AkceH-Index: 2
#2Olatunji B. AleseH-Index: 9
Last. Bassel F. El-Rayes (Emory University)H-Index: 29
view all 6 authors...
830Background: XL888 is a selective inhibitor of heat shock protein 90 (HSP90). It modulates several oncogenic signaling pathways, and the tumor microenvironment. In preclinical models, XL888 poten...
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#1Matthew R. Farren (Emory University)H-Index: 2
#1Matthew R. FarrenH-Index: 5
Last. Gregory B. LesinskiH-Index: 29
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Pancreatic ductal adenocarcinoma (PDAC) has dismal 5-year survival (<9%). We hypothesize that exposure of tumors to conventional therapies may preferentially modulate immune biomarkers in the tumor microenvironment in PDAC. PDAC patients who underwent upfront surgical resection or who received neoadjuvant FOLFIRINOX with or without neoadjuvant radiotherapy followed by surgical resection were selected for study. Total expression of immunologically relevant transcripts and spatially resolved expre...
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#1Michael B. Ware (Emory University)H-Index: 1
Last. Gregory B. LesinskiH-Index: 29
view all 6 authors...
Pancreatic ductal adenocarcinoma (PDAC) is rarely detected early, instead presenting in patients as advanced metastatic disease once symptoms are evident. Given the central role of metastasis in pancreatic tumor progression and mortality, there is an urgent need for further investigation of how PDAC metastasizes and for novel treatment strategies targeting PDAC metastasis. A prominent histopathologic feature of PDAC is a desmoplastic, fibrotic stroma consisting of extracellular matrix components...
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