Kevin J. Gaffney
University of Southern California
In vivoCOX-2 inhibitorBortezomibProteasome inhibitorPharmacology
What is this?
Publications 16
#1Maira Soto (UA: University of Arizona)H-Index: 1
#2Kevin J. Gaffney (UA: University of Arizona)H-Index: 8
Last. Kathleen E. Rodgers (UA: University of Arizona)H-Index: 32
view all 3 authors...
Patients with Type 2 Diabetes Mellitus (T2DM) suffer from a higher incidence and severity of pulmonary infections. This is likely due to immune impairment and structural abnormalities caused by T2DM-induced oxidative stress (OS) and chronic inflammation. Modulation of the Renin Angiotensin System (RAS) through blockade of the actions of angiotensin II (AII), or inducing the protective pathway, has the potential to reduce these pathological pathways. The effects of Angiotensin 1-7 [A(1-7)] and No...
#1Kevin J. Gaffney (UA: University of Arizona)H-Index: 8
#2Michael Weinberg (SC: University of Southern California)
Last. Kathleen E. Rodgers (UA: University of Arizona)H-Index: 32
view all 5 authors...
Though widely used, cytotoxic chemotherapy is associated with potentially life threatening drug-induced neutropenia, thrombocytopenia, and anemia.[1][1]–[3][2] Beyond the acute dangers of infection, severe fatigue and uncontrolled bleeding, the hematological toxicities associated with these agents
#1Stephen J. Glynn (SC: University of Southern California)H-Index: 1
#2Kevin J. Gaffney (SC: University of Southern California)H-Index: 8
Last. Nicos A. Petasis (SC: University of Southern California)H-Index: 69
view all 5 authors...
The green tea polyphenol epigallocatechin-3-gallate (EGCG) was reported to effectively antagonize the ability of Bortezomib (BZM) to induce apoptosis in cancer cells. This interaction was attributed to the formation of a covalent adduct between a phenolic moiety of EGCG with the boronic acid group of Bortezomib. However, the structural details of this boron adduct and the molecular factors that contribute to its formation and its ability to inhibit Bortezomib's activity remain unclear. This pape...
6 CitationsSource
#1Yinghui Jane E. Huang (APU: Azusa Pacific University)
#2Kevin J. Gaffney (SC: University of Southern California)H-Index: 8
Last. Melissa J. LaBonte (APU: Azusa Pacific University)H-Index: 24
view all 6 authors...
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Despite new and improved chemotherapy treatments for colorectal cancer (CRC) contributing to enhanced treatment response rates and patient prognosis, it has been suggested that an overwhelming 90% of metastatic CRC patients encounter treatment failure due to drug resistance. The Interleukin-8/CXCR2 pathway has been validated as a promising target for novel chemotherapy due to its overarching effects on various cell types withi...
#1Nicos A. PetasisH-Index: 69
#2Thomas C. ChenH-Index: 39
Last. Stan G. LouieH-Index: 31
view all 9 authors...
#1Simmy Thomas (SC: University of Southern California)H-Index: 9
#2Natasha Sharma (SC: University of Southern California)H-Index: 6
Last. Axel H. Schönthal (SC: University of Southern California)H-Index: 40
view all 11 authors...
Abstract The cellular processes of autophagy and endoplasmic reticulum stress (ERS) appear to be interconnected, and it has been proposed that autophagy may serve to reduce ERS via removal of terminally misfolded and aggregated proteins. Conversely, there are indications that blockage of autophagy may increase ERS. Based on earlier work demonstrating that pharmacologically aggravated ERS can result in tumor cell killing, we investigated whether blockage of autophagy would enhance this effect in ...
32 CitationsSource
#1Nimanthi Jayathilaka (SC: University of Southern California)H-Index: 7
#2Aidong Han (SC: University of Southern California)H-Index: 15
Last. Lin Chen (SC: University of Southern California)H-Index: 50
view all 13 authors...
Enzymes that modify the epigenetic status of cells provide attractive targets for therapy in various diseases. The therapeutic development of epigenetic modulators, however, has been largely limited to direct targeting of catalytic active site conserved across multiple members of an enzyme family, which complicates mechanistic studies and drug development. Class IIa histone deacetylases (HDACs) are a group of epigenetic enzymes that depends on interaction with Myocyte Enhancer Factor-2 (MEF2) fo...
22 CitationsSource
#2Aidong HanH-Index: 15
Last. Lin ChenH-Index: 50
view all 9 authors...
#1Angela Ferrario (Children's Hospital Los Angeles)H-Index: 24
#2Sophia Lim (Children's Hospital Los Angeles)H-Index: 1
Last. Charles J. Gomer (SC: University of Southern California)H-Index: 42
view all 8 authors...
Abstract Photodynamic therapy (PDT) effectiveness can be improved by employing combined modality approaches involving pharmaceuticals targeting the tumor microenvironment and/or tumor cell death pathways. In one approach, combining PDT with celecoxib improves long-term tumoricidal activity without increasing normal tissue photosensitization. However, side effects arising from the use of coxib based cyclooxygenase-2 (COX-2) inhibitors, including cardiovascular injury, decreases the clinical appli...
16 CitationsSource