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Erika Sasaki
Central Institute for Experimental Animals
137Publications
20H-index
2,298Citations
Publications 137
Newest
#1Eri Tabata (Kogakuin University)H-Index: 5
#2Akinori Kashimura (Kogakuin University)H-Index: 7
Last.Peter O. BauerH-Index: 17
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Chitin is a polymer of N-acetyl-D-glucosamine (GlcNAc) and a main constituent of insects’ exoskeleton. Insects are rich in protein with high energy conversion efficiency. Recently, we have reported that acidic chitinases (Chia) act as digestive enzymes in mouse, pig and chicken (omnivorous) but not in dog (carnivorous) and bovine (herbivorous), indicating that feeding behavior affects Chia expression levels, and determines chitin digestibility in the particular animals. Common marmoset (Callithr...
#2Satsuki FukudaH-Index: 4
Last.Masayuki ShimodaH-Index: 27
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Common marmosets have attracted considerable attention as a small standard primate model in biomedical research. However, no marmoset diabetes model is available. Here, we established a marmoset diabetes model via the combination of partial pancreatectomy and intravenous streptozotocin (STZ). A partial pancreatectomy was performed in 11 common marmosets and multiple STZ doses were intravenously administered. Diabetes was diagnosed upon sustained hyperglycaemia (nonfasting blood glucose level >20...
#1Sho Yoshimatsu (Keio: Keio University)H-Index: 1
#2Junko Okahara (Central Institute for Experimental Animals)H-Index: 5
Last.Hideyuki Okano (Keio: Keio University)H-Index: 110
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Genome editing technology greatly facilitates the genetic modification of various cells and animals. The common marmoset (Callithrix jacchus), a small non-human primate which exhibits high reproductive efficiency, is a widely used animal model in biomedical research. Developing genome editing techniques in the common marmoset will further enhance its utility. Here, we report the successful establishment of a knock-in (KI) method for marmoset embryonic stem cells (ESCs), which is based on the CRI...
#1Wakako Kumita (Central Institute for Experimental Animals)H-Index: 2
#2Kenya Sato (Central Institute for Experimental Animals)H-Index: 3
Last.Yasubumi Sakakibara (Keio: Keio University)H-Index: 29
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Genetically modified nonhuman primates (NHP) are useful models for biomedical research. Gene editing technologies have enabled production of target-gene knock-out (KO) NHP models. Target-gene-KO/knock-in (KI) efficiency of CRISPR/Cas9 has not been extensively investigated in marmosets. In this study, optimum conditions for target gene modification efficacies of CRISPR/mRNA and CRISPR/nuclease in marmoset embryos were examined. CRISPR/nuclease was more effective than CRISPR/mRNA in avoiding mosai...
#1Takahiko Noro (Central Institute for Experimental Animals)H-Index: 9
#2Kazuhiko NamekataH-Index: 24
Last.Xiaoli GuoH-Index: 17
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The common marmoset (Callithrix jacchus) is a non-human primate that provides valuable models for neuroscience and aging research due to its anatomical similarities to humans and relatively short lifespan. This study was carried out to examine whether aged marmosets develop glaucoma, as seen in humans. We found that 11% of the aged marmosets presented with glaucoma-like characteristics; this incident rate is very similar to that in humans. Magnetic resonance imaging showed a significant volume l...
#1Sho Yoshimatsu (Keio: Keio University)H-Index: 1
#2Mari Nakamura (Keio: Keio University)
Last.Hideyuki Okano (Keio: Keio University)H-Index: 110
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Abstract The common marmoset (marmoset; Callithrix jacchus) harbors various desired features as a non-human primate (NHP) model for neuroscience research. Recently, efforts have been made to induce neural cells in vitro from marmoset pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), which are characterized by their capacity to differentiate into all cell types from the three germ layers. Successful generation of marmoset neural cells...
#1Mayutaka Nakajima (Keio: Keio University)
#2Sho Yoshimatsu (Keio: Keio University)H-Index: 1
Last.Hideyuki Okano (Keio: Keio University)H-Index: 110
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Abstract The common marmoset (marmoset; Callithrix jacchus ) shows anatomical and physiological features that are in common with humans. Establishing induced pluripotent stem cells (iPSCs) from marmosets holds promise for enhancing the utility of the animal model for biomedical and preclinical studies. However, in spite of the presence of some previous reports on marmoset iPSCs, the reprogramming technology in marmosets is still under development. In particular, the efficacy of RNA-based reprogr...
#1Toshiaki Watanabe (Central Institute for Experimental Animals)
#2Shun Yamazaki (Central Institute for Experimental Animals)
Last.Hiroshi Suemizu (Central Institute for Experimental Animals)H-Index: 21
view all 11 authors...
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