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Mikel Tainta
Publications 13
Published on Apr 1, 2019in Alzheimers & Dementia 14.42
Alberto Lleó31
Estimated H-index: 31
Daniel Alcolea23
Estimated H-index: 23
+ 25 AuthorsRosalinde E.R. Slot5
Estimated H-index: 5
(VUmc: VU University Medical Center)
Abstract Introduction Within-person trajectories of cerebrospinal fluid (CSF) biomarkers in Alzheimer's disease (AD) are not well defined. Methods We included 467 subjects from the BIOMARKAPD study with at least two serial CSF samples. Diagnoses were subjective cognitive decline (n = 75), mild cognitive impairment (n = 128), and AD dementia (n = 110), and a group of cognitively unimpaired subjects (n = 154) were also included. We measured baseline and follow-up CSF levels of total tau (t-tau), p...
Published on May 1, 2019in Alzheimers & Dementia 14.42
Min Kim5
Estimated H-index: 5
('KCL': King's College London),
Min Kim + 48 AuthorsDavid J. Merkler
Abstract Introduction A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers. Methods This study analyzed 593 plasma samples selected from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery study, of i...
Published on May 1, 2019in Alzheimers & Dementia 14.42
Isabelle Bos3
Estimated H-index: 3
(UM: Maastricht University),
Stephanie J.B. Vos13
Estimated H-index: 13
(UM: Maastricht University)
+ 29 AuthorsJill C. Richardson32
Estimated H-index: 32
(GSK: GlaxoSmithKline)
Abstract Introduction We investigated relations between amyloid-β (Aβ) status, apolipoprotein E ( APOE ) e4, and cognition, with cerebrospinal fluid markers of neurogranin (Ng), neurofilament light (NFL), YKL-40, and total tau (T-tau). Methods We included 770 individuals with normal cognition, mild cognitive impairment, and Alzheimer's disease (AD)-type dementia from the EMIF-AD Multimodal Biomarker Discovery study. We tested the association of Ng, NFL, YKL-40, and T-tau with Aβ status (Aβ− vs. ...
Published on Apr 1, 2019in Talanta 4.92
Ane Iriondo2
Estimated H-index: 2
Mikel Tainta3
Estimated H-index: 3
+ 5 AuthorsBeatriz Abad-García11
Estimated H-index: 11
(UPV/EHU: University of the Basque Country)
Abstract The cerebrospinal fluid (CSF) lipidome is attracting increasing attention due to the importance of lipids in brain molecular signaling and their involvement in several neurological diseases. Different solvent systems have been used for the extraction of multiple lipid classes from CSF but no comparative study of the effectiveness of these protocols has been carried out. To optimize CSF lipid extraction for lipidomic measurements by untargeted ultra-high performance liquid chromatography...
Published on Jul 17, 2018in Neurology 8.69
Mirian Ecay-Torres4
Estimated H-index: 4
Ainara Estanga10
Estimated H-index: 10
+ 10 AuthorsArantzazu Arrospide11
Estimated H-index: 11
Objective To investigate the cognitive profile of healthy individuals with increased Cardiovascular Risk Factors, Aging and Dementia (CAIDE) dementia risk score and to explore whether this association is related to vascular burden and CSF biomarkers of amyloidosis and neurodegeneration. Method Cognitively normal participants (mean age 57.6 years) from the Gipuzkoa Alzheimer Project study were classified as having high risk (HR; n = 82) or low risk (LR; n = 293) for dementia according to a CAIDE ...
Published on Jul 1, 2018in Alzheimers & Dementia 14.42
Olivia Belbin16
Estimated H-index: 16
Raúl Núñez-Llaves2
Estimated H-index: 2
+ 18 AuthorsLorena Rami30
Estimated H-index: 30