Match!
Luiza Guilherme
University of São Paulo
116Publications
32H-index
2,723Citations
Publications 117
Newest
#1Edilberto Postol (USP: University of São Paulo)H-Index: 11
#2Luiz Carlos de Sá-Rocha (USP: University of São Paulo)H-Index: 11
Last.Luiza Guilherme (USP: University of São Paulo)H-Index: 32
view all 8 authors...
Streptococcus pyogenes infection continues to be a worldwide public health problem causing various diseases in humans and plays an important role in the pathogenesis of rheumatic fever and rheumatic heart disease. We developed a vaccine candidate to prevent S. pyogenes infections, identified as StreptInCor, that presented promising results in mouse models. A certified and independent laboratory conducted two repeated intramuscular dose toxicity tests (28 days, four weekly injections). The first ...
Source
Source
#1Sandra Jeremias Catarino (UFPR: Federal University of Paraná)H-Index: 4
#2Fabiana Antunes Andrade (UFPR: Federal University of Paraná)H-Index: 4
Last.Iara Messias-Reason (UFPR: Federal University of Paraná)H-Index: 15
view all 5 authors...
Rheumatic fever (RF) and its subsequent progression to rheumatic heart disease (RHD) are chronic inflammatory disorders prevalent in children and adolescents in underdeveloped countries, and a contributing factor for high morbidity and mortality rates worldwide. Their primary cause is oropharynx infection by Streptococcus pyogenes, whose acetylated residues are recognized by ficolin-1. This is the only membrane-bound, as well as soluble activator molecule of the complement lectin pathway (LP). A...
1 CitationsSource
#1Luis Klaus A. da Rocha (USP: University of São Paulo)H-Index: 1
#2Samar Freschi de Barros (USP: University of São Paulo)H-Index: 1
Last.Luiza Guilherme (USP: University of São Paulo)H-Index: 32
view all 15 authors...
Hematopoietic stem cell transplantation (HSCT) is an important therapeutic option for some hematological diseases. However, patients who undergo HSCT present a state of immunodeficiency that causes significant mortality. Reconstitution of thymic function is needed to support the immune system. One way to measure thymic function is through T-cell receptor excision circle (TREC) quantification. TRECs are generated by T-cell receptor gene rearrangements during T-cell maturation in the thymus and re...
1 CitationsSource
16 CitationsSource
#1Kelen C. R. Malmegrim (USP: University of São Paulo)H-Index: 15
#2Júlia Teixeira Cottas de Azevedo (USP: University of São Paulo)H-Index: 3
Last.Maria Amélia de Campos Oliveira (USP: University of São Paulo)H-Index: 19
view all 22 authors...
Autologous hematopoietic stem cell transplantation (AHSCT) increases C-peptide levels and induces insulin-independence in patients with type 1 diabetes. This study aimed to investigate how clinical outcomes may associate with the immunological status, especially concerning the balance between immunoregulation and autoreactivity. Twenty-one type 1 diabetes patients were monitored after AHSCT, and assessed every six months for duration of insulin independence, C-peptide levels, frequencies of isle...
26 CitationsSource
Autoimmune inflammatory reactions leading to rheumatic fever (RF) and rheumatic heart disease (RHD) result from untreated Streptococcus pyogenes throat infections in individuals who exhibit genetic susceptibility. Immune effector mechanisms have been described that lead to heart tissue damage culminating in mitral and aortic valve dysfunctions. In myxomatous valve degeneration (MXD), the mitral valve is also damaged due to non-inflammatory mechanisms. Both diseases are characterized by structura...
17 CitationsSource
#1Luiza GuilhermeH-Index: 32
#2Pedro Azevedo MingH-Index: 1
Last.Jorge KalilH-Index: 4
view all 3 authors...
Source
#1Luiza Guilherme (USP: University of São Paulo)H-Index: 32
#2Roney Orismar Sampaio (USP: University of São Paulo)H-Index: 14
Last.Jorge Kalil (USP: University of São Paulo)H-Index: 48
view all 7 authors...
Rheumatic fever (RF) is the prototype of postinfectious autoimmune diseases. Similarities of structure and/or spatial conformation between Streptococcus pyogenes and human tissue proteins lead to autoimmune reactions due to molecular mimicry. The activation of T and B lymphocytes involves several genetically controlled molecules that act in both the innate and adaptive immune response. In this chapter, we describe the strains of bacteria that are more commonly involved in the development of RF w...
Source
#1Luiza GuilhermeH-Index: 32
#2Pedro Azevedo MingH-Index: 1
Last.Jorge KalilH-Index: 4
view all 3 authors...
1 CitationsSource
12345678910