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Luiza Guilherme
University of São Paulo
86Publications
29H-index
2,099Citations
Publications 86
Newest
Published on Dec 1, 2019in Scientific Reports 4.01
Edilberto Postol11
Estimated H-index: 11
(USP: University of São Paulo),
Luiz Carlos de Sá-Rocha11
Estimated H-index: 11
(USP: University of São Paulo)
+ 5 AuthorsLuiza Guilherme29
Estimated H-index: 29
(USP: University of São Paulo)
Streptococcus pyogenes infection continues to be a worldwide public health problem causing various diseases in humans and plays an important role in the pathogenesis of rheumatic fever and rheumatic heart disease. We developed a vaccine candidate to prevent S. pyogenes infections, identified as StreptInCor, that presented promising results in mouse models. A certified and independent laboratory conducted two repeated intramuscular dose toxicity tests (28 days, four weekly injections). The first ...
Published on Dec 18, 2018in Frontiers in Immunology 4.72
Sandra Jeremias Catarino4
Estimated H-index: 4
,
Fabiana Antunes Andrade3
Estimated H-index: 3
+ 2 AuthorsIara Messias-Reason14
Estimated H-index: 14
Rheumatic fever (RF) and its subsequent progression to rheumatic heart disease (RHD) are chronic inflammatory disorders prevalent in children and adolescents in underdeveloped countries, and a contributing factor for high morbidity and mortality rates worldwide. Their primary cause is oropharynx infection by Streptococcus pyogenes, whose acetylated residues are recognized by ficolin-1. This is the only membrane-bound, as well as soluble activator molecule of the complement lectin pathway (LP). A...
Published on Sep 7, 2018in Frontiers in Immunology 4.72
Luis Klaus A. da Rocha1
Estimated H-index: 1
(USP: University of São Paulo),
Samar Freschi de Barros1
Estimated H-index: 1
(USP: University of São Paulo)
+ 12 AuthorsAna Claúdia F. dos Santos1
Estimated H-index: 1
Hematopoietic stem cell transplantation (HSCT) is an important therapeutic option for some hematological diseases. However, patients who undergo HSCT present a state of immunodeficiency that causes significant mortality. Reconstitution of thymic function is needed to support the immune system. One way to measure thymic function is through T-cell receptor excision circle (TREC) quantification. TRECs are generated by T-cell receptor gene rearrangements during T-cell maturation in the thymus and re...
Published on Jul 25, 2017in Current Protein & Peptide Science 1.89
Luiza Guilherme29
Estimated H-index: 29
,
S. Freschi de Barros3
Estimated H-index: 3
+ 6 AuthorsJorge Kalil46
Estimated H-index: 46
Published on Feb 22, 2017in Frontiers in Immunology 4.72
Kelen C. R. Malmegrim13
Estimated H-index: 13
(USP: University of São Paulo),
Júlia T. C. de Azevedo3
Estimated H-index: 3
(USP: University of São Paulo)
+ 19 AuthorsDaniela A. Moraes11
Estimated H-index: 11
(USP: University of São Paulo)
Autologous hematopoietic stem cell transplantation (AHSCT) increases C-peptide levels and induces insulin-independence in patients with type 1 diabetes. This study aimed to investigate how clinical outcomes may associate with the immunological status, especially concerning the balance between immunoregulation and autoreactivity. Twenty-one type 1 diabetes patients were monitored after AHSCT, and assessed every six months for duration of insulin independence, C-peptide levels, frequencies of isle...
Published on Jan 1, 2017
Luiza Guilherme4
Estimated H-index: 4
,
Pedro Azevedo Ming1
Estimated H-index: 1
,
Jorge Kalil5
Estimated H-index: 5
Published on Jan 1, 2017
Luiza Guilherme4
Estimated H-index: 4
,
Pedro Azevedo Ming1
Estimated H-index: 1
,
Jorge Kalil5
Estimated H-index: 5
Published on Jan 1, 2017
Luiza Guilherme29
Estimated H-index: 29
(USP: University of São Paulo),
Roney Orismar Sampaio14
Estimated H-index: 14
(USP: University of São Paulo)
+ 4 AuthorsJorge Kalil46
Estimated H-index: 46
(USP: University of São Paulo)
Rheumatic fever (RF) is the prototype of postinfectious autoimmune diseases. Similarities of structure and/or spatial conformation between Streptococcus pyogenes and human tissue proteins lead to autoimmune reactions due to molecular mimicry. The activation of T and B lymphocytes involves several genetically controlled molecules that act in both the innate and adaptive immune response. In this chapter, we describe the strains of bacteria that are more commonly involved in the development of RF w...
Published on Dec 1, 2016
Jonathan R. Carapetis58
Estimated H-index: 58
(PMH: Princess Margaret Hospital for Children),
Andrea Beaton13
Estimated H-index: 13
+ 8 AuthorsRosemary Wyber7
Estimated H-index: 7
Acute rheumatic fever (ARF) is the result of an autoimmune response to pharyngitis caused by infection with group A Streptococcus. The long-term damage to cardiac valves caused by ARF, which can result from a single severe episode or from multiple recurrent episodes of the illness, is known as rheumatic heart disease (RHD) and is a notable cause of morbidity and mortality in resource-poor settings around the world. Although our understanding of disease pathogenesis has advanced in recent years, ...
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