Marion Mafham
University of Oxford
EndocrinologyCardiologyKidney diseaseDiabetes mellitusMedicine
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Publications 24
#1Peter Horby (University of Oxford)H-Index: 43
#2Wei Shen Lim (NUH: Nottingham University Hospitals NHS Trust)H-Index: 26
Last. Einas Elmahi (Northampton General Hospital)H-Index: 1
view all 26 authors...
Background: Coronavirus disease 2019 (COVID-19) is associated with diffuse lung damage. Corticosteroids may modulate immune-mediated lung injury and reducing progression to respiratory failure and death. Methods: The Randomised Evaluation of COVID-19 therapy (RECOVERY) trial is a randomized, controlled, open-label, adaptive, platform trial comparing a range of possible treatments with usual care in patients hospitalized with COVID-19. We report the preliminary results for the comparison of dexam...
1 CitationsSource
#1Barbara CasadeiH-Index: 48
#1Barbara CasadeiH-Index: 4
Last. Chris P GaleH-Index: 27
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#1Marion Mafham (Clinical Trial Service Unit)H-Index: 10
#2Louise Bowman (University of Oxford)H-Index: 19
Last. Jane Armitage (University of Oxford)H-Index: 51
view all 4 authors...
Reliable assessment of the effects of an intervention usually requires large randomised trials but such studies are becoming increasingly complex and costly to run. ‘Streamlined’ trials are needed in which every aspect of the trial design and conduct is simplified, retaining only those elements needed to answer the research question and ensure the safety of the individual participants. In this review we discuss how the trial ‘A Study of Cardiovascular Events iN Diabetes’ (ASCEND) was streamlined...
#1Sarah Parish (Medical Research Council)H-Index: 58
#2Marion Mafham (Clinical Trial Service Unit)H-Index: 10
Last. Jane ArmitageH-Index: 51
view all 11 authors...
2 CitationsSource
#1M S Chan (University of Oxford)H-Index: 1
#1Mei Sum Chan (University of Oxford)
Last. Sarah Parish (University of Oxford)H-Index: 58
view all 8 authors...
Background: Age is the strongest risk factor for most chronic diseases, and yet individuals may age at different rates biologically. A biological age formed from biomarkers may be a stronger risk factor than chronological age and understanding what factors contribute to it could provide insight into new opportunities for disease prevention. Methods and findings: Among 480,019 UK Biobank participants aged 40-70 recruited in 2006-2010 and followed up for 6-12 years via linked death registry and se...
1 CitationsSource
#1Pang Yao (Clinical Trial Service Unit)H-Index: 3
#1Pang Yao (Clinical Trial Service Unit)H-Index: 1
Last. Robert Clarke (Clinical Trial Service Unit)H-Index: 127
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Importance Vitamin D and calcium supplements are recommended for the prevention of fracture, but previous randomized clinical trials (RCTs) have reported conflicting results, with uncertainty about optimal doses and regimens for supplementation and their overall effectiveness. Objective To assess the risks of fracture associated with differences in concentrations of 25-hydroxyvitamin D (25[OH]D) in observational studies and the risks of fracture associated with supplementation with vitamin D alo...
10 CitationsSource
#1I Hammami (University of Oxford)H-Index: 1
#2Marion Mafham (University of Oxford)H-Index: 10
Last. Sarah Parish (University of Oxford)H-Index: 58
view all 4 authors...
#1Louise BowmanH-Index: 19
#2Marion MafhamH-Index: 10
Last. Jill BartonH-Index: 4
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6 CitationsSource
#2Louise BowmanH-Index: 19
#3Marion MafhamH-Index: 10
Last. Jane ArmitageH-Index: 51
view all 27 authors...
© 2018 Massachusetts Medical Society. Background: Diabetes mellitus is associated with an increased risk of cardiovascular events. Aspirin use reduces the risk of occlusive vascular events but increases the risk of bleeding; the balance of benefits and hazards for the prevention of first cardiovascular events in patients with diabetes is unclear. Methods: We randomly assigned adults who had diabetes but no evident cardiovascular disease to receive aspirin at a dose of 100 mg daily or matching pl...
148 CitationsSource
#2Louise BowmanH-Index: 19
#3Marion MafhamH-Index: 10
Last. Jane ArmitageH-Index: 51
view all 27 authors...
© 2018 Massachusetts Medical Society. Background: Increased intake of n-3 fatty acids has been associated with a reduced risk of cardiovascular disease in observational studies, but this finding has not been confirmed in randomized trials. It remains unclear whether n-3 (also called omega-3) fatty acid supplementation has cardiovascular benefit in patients with diabetes mellitus. Methods: We randomly assigned 15,480 patients with diabetes but without evidence of atherosclerotic cardiovascular di...
53 Citations