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George R. Washko
Brigham and Women's Hospital
RadiologyPhysical therapyCOPDLungMedicine
358Publications
51H-index
8,975Citations
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Publications 374
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Abstract We present an open-source framework for pulmonary fissure completeness assessment. Fissure incompleteness has been shown to associate with emphysema treatment outcomes, motivating the development of tools that facilitate completeness estimation. Generally, the task of fissure completeness assessment requires accurate detection of fissures and definition of the boundary surfaces separating the lung lobes. The framework we describe acknowledges a) the modular nature of fissure detection a...
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#1Stefanie E. Mason (Brigham and Women's Hospital)H-Index: 3
#2Jinyi Zhu (Harvard University)H-Index: 1
Last. Ankur Pandya (Harvard University)H-Index: 16
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Approximately 30–50% of hemodynamically stable patients presenting with acute pulmonary embolism (PE) have evidence of right ventricular (RV) dysfunction. These patients are classified as submassive PE and the role of reperfusion therapy remains unclear. We sought to identify the circumstances under which catheter-directed thrombolysis (CDT) would represent high-value care for submassive PE. We used a computer-based, individual-level, state-transition model with one million simulated patients to...
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#1George R. Washko (Brigham and Women's Hospital)H-Index: 51
#2Laura A. Colangelo (NU: Northwestern University)H-Index: 43
Last. Ravi Kalhan (NU: Northwestern University)H-Index: 23
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Abstract Background Peak lung function and rate of decline predict future airflow obstruction and non-respiratory comorbid conditions. Associations between lung function trajectories and emphysema have not been explored. Methods Using data from the population-based CARDIA Study, we sought to describe the prevalence of visually ascertained emphysema at multiple time points and contextualize its development based upon participant's adult life course measures of lung function. 3171 men and women we...
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#1David C. LaFon (UAB: University of Alabama at Birmingham)H-Index: 3
#2Surya P. Bhatt (UAB: University of Alabama at Birmingham)H-Index: 24
Last. J. Michael WellsH-Index: 17
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Chronic obstructive pulmonary disease (COPD) is one of the leading causes of mortality worldwide [1]. Pulmonary hypertension (PH) has been associated with reduced survival among individuals with COPD [2] and is an independent risk factor for mortality following acute exacerbations of COPD (AECOPD) [3]. Measurement of the pulmonary artery to aorta (PA:A) ratio by computed tomography (CT) and assessment of PA enlargement (PA:A>1) outperforms echocardiography in identifying PH in severe COPD [4], a...
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#1Samuel Y. AshH-Index: 8
Last. Raúl San José EstéparH-Index: 34
view all 61 authors...
1 CitationsSource
#1Yuka Okajima (Brigham and Women's Hospital)H-Index: 13
#2Carolyn E. Come (Brigham and Women's Hospital)H-Index: 11
Last. Seth Kligerman (UCSD: University of California, San Diego)H-Index: 15
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Abstract Background Mucous exudates occluding the lumen of small airways are associated with reduced lung function and mortality in COPD subjects; however, luminal plugs in large airways have not been widely studied. We aimed to examine the associations of chest computed tomography (CT)-identified luminal plugging with lung function, health-related quality of life, and COPD phenotypes. Methods We randomly selected 100 smokers without COPD and 400 with COPD from the COPDGene Study. Luminal pluggi...
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#1David Bermejo-Pelaez (UPM: Technical University of Madrid)H-Index: 3
#2Samuel Y. Ash (Brigham and Women's Hospital)H-Index: 8
Last. Maria J. Ledesma-Carbayo (UPM: Technical University of Madrid)H-Index: 19
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Subtle interstitial changes in the lung parenchyma of smokers, known as Interstitial Lung Abnormalities (ILA), have been associated with clinical outcomes, including mortality, even in the absence of Interstitial Lung Disease (ILD). Although several methods have been proposed for the automatic identification of more advanced Interstitial Lung Disease (ILD) patterns, few have tackled ILA, which likely precedes the development ILD in some cases. In this context, we propose a novel methodology for ...
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#1Sarah G. Chu (Brigham and Women's Hospital)H-Index: 5
#2Sergio Poli De Frias (Brigham and Women's Hospital)H-Index: 1
Last. Ivan O. Rosas (Brigham and Women's Hospital)H-Index: 32
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Recent advances in high throughput omic technologies have greatly enhanced our knowledge of the molecular basis of complex lung diseases. In particular, with the advent of next generation sequencing, transcriptomic studies with RNA sequencing (RNA-seq) have yielded important insights into chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) [1, 2]. However, most studies to date have been performed on whole lung tissue, such that many unique cell type-specific gene...
1 CitationsSource
#1Peter J. Castaldi (Brigham and Women's Hospital)H-Index: 25
#2Adel Boueiz (Brigham and Women's Hospital)
Last. John E. Hokanson (University of Colorado Denver)H-Index: 58
view all 83 authors...
Abstract COPD is a heterogeneous syndrome. Many COPD subtypes have been proposed, but there is not yet consensus on how many COPD subtypes there are and how they should be defined. The COPDGene study, which has generated ten-year longitudinal chest imaging, spirometry, and molecular data, is a rich resource for relating COPD phenotypes to underlying genetic and molecular mechanisms. In this article, we place COPDGene clustering studies in context with other highly cited COPD clustering studies, ...
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