Kanga Rani Selvaduray
Malaysian Palm Oil Board
Publications 28
Last.Ammu Kutty RadhakrishnanH-Index: 21
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Cancer is a devastating disease that has claimed many lives. Natural bioactive agents from plants are gaining wide attention for their anticancer activities. Several studies have found that natural plant-based bioactive compounds can enhance the efficacy of chemotherapy, and in some cases ameliorate some of the side-effects of drugs used as chemotherapeutic agents. In this paper, we have reviewed the literature on the anticancer effects of four plant-based bioactive compounds namely, curcumin, m...
1 CitationsSource
#1Tony Kock Wai NgH-Index: 1
#2Mahenderan Appukutty (UiTM: Universiti Teknologi MARA)H-Index: 4
Last.Kanga Rani Selvaduray (Malaysian Palm Oil Board)H-Index: 12
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Abstract Cooking oil serves as an important energy source for daily dietary fat intake. Fat plays important physiological roles in normal individuals and even more in individuals with a need for higher energy intake such as sportsmen; hence it has a major role in sports nutrition. This review attempts to discuss the types of cooking oils available and their basic fatty acid compositions that determine their characteristics and applications in meal preparations. The use of various oils is discuss...
#1Yee-Lin Gan (UPM: Universiti Putra Malaysia)H-Index: 1
#2Ju-Yen Fu (Malaysian Palm Oil Board)H-Index: 4
Last.Puvaneswari Meganathan (Malaysian Palm Oil Board)H-Index: 5
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Tocotrienols, the unsaturated form of vitamin E, were reported to modulate platelet aggregation and thrombotic mechanisms in pre-clinical studies. Using a Food and Drug Administration (FDA)-approved cartridge-based measurement system, a randomised, double-blind, crossover and placebo-controlled trial involving 32 metabolic syndrome adults was conducted to investigate the effect of palm-based tocotrienols and tocopherol (PTT) mixture supplementation on platelet aggregation reactivity. The partici...
1 CitationsSource
#1H-L CheH-Index: 1
#2M.S. KanthimathiH-Index: 13
Last.K-T TengH-Index: 1
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Acute effects of a single dose of tocotrienols on insulinemic and inflammatory responses in metabolic syndrome subjects after a high-fat challenge
1 CitationsSource
#1Yee Lin GanH-Index: 1
#2Oi Ming LaiH-Index: 28
Last.Ju Yen FuH-Index: 1
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Previous studies have reported that tocotrienols (T3) possess many distinct properties such as antioxidant, cardioprotective, neuroprotective, anti-cancer, anti-inflammatory and anti-angiogenic, which are beneficial for the improvement of human health. However, there is limited data available on the safety assessment of T3 compared to tocopherols (T). A randomised, double-blinded, cross-over and placebo-controlled human clinical trial was conducted to determine the safety and tolerance of T3 sup...
1 CitationsSource
#1Radhika Loganathan (International Medical University)H-Index: 4
#2Ammu Kutty Radhakrishnan (International Medical University)H-Index: 21
Last.Kalanithi Nesaretnam (Malaysian Palm Oil Board)H-Index: 23
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Palm oil contains a number of phytonutrients. To date, most of the studies using palm phytonutrients have focused on palm vitamin E. The objective of this study was to compare the anti-cancer activities of four major palm phytonutrients, namely tocotrienol-rich fraction, carotenoids, squalene and co-enzyme Q10 using some cell-based assays. Two human breast cancer cell lines, the highly aggressive triple-negative MDA-MB-231 and the estrogen-dependent MCF-7 cells, were treated with these palm phyt...
4 CitationsSource
#1Radhika Loganathan (International Medical University)H-Index: 4
#2Kanga Rani Selvaduray (Malaysian Palm Oil Board)H-Index: 12
Last.Ammu Kutty Radhakrishnan (International Medical University)H-Index: 21
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Objectives: Tocotrienols and tocopherols are mem- bers of the vitamin E family, with similar struc- tures; however, only tocotrienols have been reported to achieve potent anti-cancer effects. The study described here has evaluated anti-cancer activity of vitamin E to elucidate mechanisms of cell death, using human breast cancer cells. Materials and methods: Anti-cancer activity of a tocotrienol-rich fraction (TRF) and a tocotrienol- enriched fraction (TEF) isolated from palm oil, as well as pure...
30 CitationsSource
#1Ammu Kutty Radhakrishnan (International Medical University)H-Index: 21
#2Dashayini Mahalingam (International Medical University)H-Index: 2
Last.Kalanithi Nesaretnam (Malaysian Palm Oil Board)H-Index: 23
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This study compared the ability of three forms of vitamin E [tocotrienol-rich fraction (TRF), alpha-tocopherol (-T), and delta-tocotrienol (-T3)] to enhance immune response to tetanus toxoid (TT) immunisation in a mouse model. Twenty BALB/c mice were divided into four groups of five mice each. The mice were fed with the different forms of vitamin E (1 mg) or vehicle daily for two weeks before they were given the TT vaccine [4 Lf] intramuscularly (i.m.). Booster vaccinations were given on days 28...
15 CitationsSource