Theebaa Anasamy
University of Malaya
Caspase 3ApoptosisCytochrome cCaspase 8Biochemistry
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Publications 7
#1Theebaa Anasamy (UM: University of Malaya)H-Index: 5
#2Chin Fei Chee (UM: University of Malaya)H-Index: 10
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
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Abstract This study reports the in vivo performance of two tribenzyltin carboxylate complexes, tri(4-fluorobenzyl)tin[(N,N-diisopropylcarbamothioyl)sulfanyl]acetate (C1) and tribenzyltin isonicotinate (C9), in their native form as well as in a poly(lactic-co-glycolic acid) (PLGA)-based nanoformulation, to assess their potential to be translated into clinically useful agents. In a 4T1 murine metastatic mammary tumour model, single intravenous administration of C1 (2.7 mg/kg) and C9 (2.1 mg/kg; 2....
#1Theebaa Anasamy (UM: University of Malaya)H-Index: 5
#2Chun Keng Thy (UM: University of Malaya)H-Index: 1
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
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Abstract This study seeks to investigate the relationship between the structural modification and bioactivity of a series of tribenzyltin complexes with different ligands and substitutions. Complexation with the N,N-diisopropylcarbamothioylsulfanylacetate or isonicotinate ligands enhanced the anticancer properties of tribenzyltin compounds via delayed cancer cell-cycle progression, caspase-dependent apoptosis induction, and significant reduction in cell motility, migration and invasion. Halogena...
12 CitationsSource
Hepatocellular carcinoma (HCC) is a primary liver cancer with high global incidence and mortality rates. Current candidate drugs to treat HCC remain lacking and those in use possess undesirable side effects. In this investigation, the antiproliferative effects of dentatin (DTN), a natural coumarin, were evaluated on HepG2 cells and DTN’s probable preliminary molecular mechanisms in apoptosis induction were further investigated. DTN significantly (p 50 µg/mL) causing G 0 /G 1 cell cycle arrest vi...
5 CitationsSource
#2Abdullah RasedeeH-Index: 12
Last. Chee Wun HowH-Index: 11
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Zerumbone- (ZER-) loaded nanostructure lipid carrier (NLC) (ZER-NLC) prepared for its antileukemia effect in vitro was evaluated for its toxicological effects by observing changes in the liver, kidney, spleen, lung, heart, and brain tissues, serum biochemical parameters, total haemogram, and bone marrow stem cells. The acute toxicity study for ZER-NLC was conducted by orally treating BALB/c mice with a single dose with either water, olive oil, ZER, NLC, or ZER-NLC for 14 days. The animals were o...
13 CitationsSource
#1Kuan Beng Ng (UPM: Universiti Putra Malaysia)H-Index: 3
#2Ahmad Bustamam (UPM: Universiti Putra Malaysia)H-Index: 12
Last. Heshu Sulaiman Rahman (UPM: Universiti Putra Malaysia)H-Index: 13
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Background Boesenbergia rotunda (Roxb.) Schlecht (family zingiberaceae) is a rhizomatous herb that is distributed from north-eastern India to south-east Asia, especially in Indonesia, Thailand and Malaysia. Previous research has shown that the crude extract of this plant has cytotoxic properties. The current study examines the cytotoxic properties of boesenbergin A isolated from Boesenbergia rotunda.
22 CitationsSource
Zerumbone (ZER) isolated from Zingiber zerumbet was previously encapsulated with hydroxypropyl-β-cyclodextrin (HPβCD) to enhance ZER’s solubility in water, thus making it highly tolerable in the human body. The anticancer effects of this new ZER-HPβCD inclusion complex via apoptosis cell death were assessed in this study for the first time in liver hepatocellular cells, HepG2. Apoptosis was ascertained by morphological study, nuclear stain, and sub-G1 cell population accumulation with G2/M arres...
15 CitationsSource
#1Theebaa Anasamy (UPM: Universiti Putra Malaysia)H-Index: 5
#2Ahmad Bustamam Abdul (UPM: Universiti Putra Malaysia)H-Index: 19
Last. Heshu Sulaiman Rahman (UPM: Universiti Putra Malaysia)H-Index: 13
view all 12 authors...
The current study was designed to evaluate the in vitro cytotoxicity effect of a phenylbutenoid dimer, cis-3-(3′,4′-dimethoxyphenyl)-4-[(E)-3‴,4‴-dimethoxystyryl]cyclohex-1-ene (ZC-B11) isolated from the rhizome of Zingiber cassumunar on various cancer cell line, and normal human blood mononuclear cells, and to further investigate the involvement of apoptosis-related proteins that leads, to the probable pathway in which apoptosis is triggered. Cytotoxicity test using MTT assay showed selective i...
7 CitationsSource