Kristen J. Nadeau
Anschutz Medical Campus
EndocrinologyType 2 diabetesInsulin resistanceDiabetes mellitusMedicine
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Publications 191
#1Beza Jobira (Anschutz Medical Campus)
#2Daniel N. Frank (Anschutz Medical Campus)H-Index: 46
Last. Melanie Cree-Green (Anschutz Medical Campus)H-Index: 12
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CONTEXT: Alterations in gut microbiota relate to the metabolic syndrome, but have not been examined in at-risk obese youth with polycystic ovary syndrome (PCOS). OBJECTIVE: Compare the composition and diversity of the gut microbiota and associations with metabolic and hormonal measures between two equally obese groups of girls with or without PCOS. DESIGN: Prospective, case-control cross-sectional study. SETTING: Tertiary-care center. PARTICIPANTS: Fifty-eight obese female adolescents (PCOS N=37...
3 CitationsSource
#1Michal SchäferH-Index: 8
#2Petter BjornstadH-Index: 16
Last. Alex J. BarkerH-Index: 29
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#1Stanley Andrisse (HU: Howard University)H-Index: 1
#2Yesenia Garcia Reyes (Anschutz Medical Campus)
Last. Melanie Cree-Green (CU: University of Colorado Boulder)H-Index: 12
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#1Lauren B. Shomaker (CSU: Colorado State University)H-Index: 20
#2Lauren D. Gulley (CSU: Colorado State University)H-Index: 7
Last. Jeanelle Sheeder (University of Colorado Denver)H-Index: 25
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Background: Excess gestational weight gain (GWG) in pregnant adolescents is a major public health concern. Excess GWG increases risk of pregnancy complications as well as postpartum and offspring obesity and cardiometabolic disease. Prevention interventions for pregnant adults that target lifestyle modification (i.e., healthy eating/physical activity) show insufficient effectiveness. Pregnant adolescents have distinct social-emotional needs, which may contribute to excess GWG. From an interperso...
#1Megan M. Kelsey (University of Colorado Denver)H-Index: 11
#2Laura Pyle (University of Colorado Denver)H-Index: 18
Last. Philip Zeitler (University of Colorado Denver)H-Index: 30
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CONTEXT: Physiologic changes in glucose metabolism are well-described to occur during puberty. However, there are important gaps in understanding the interaction between obesity and the normal physiologic changes during puberty and how these changes could contribute to the increased risk of comorbidities, such as type 2 diabetes and dyslipidemia, in youth with obesity. OBJECTIVE: Compare longitudinal changes in insulin sensitivity (Si) and secretion in youth with normal weight vs. those with obe...
1 CitationsSource
#1Amy S. Shah (Cincinnati Children's Hospital Medical Center)H-Index: 16
#2Kristen J. Nadeau (University of Colorado Denver)H-Index: 30
Last. Megan M. Kelsey (University of Colorado Denver)H-Index: 11
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Abstract Youth-onset type 2 diabetes (T2D) is a formidable threat to the health of obese adolescents because of its potential for early-onset and aggressive co-morbidities and complications. The physiology of youth-onset T2D differs from T2D in adults and is associated with a greater degree of insulin resistance, a more rapid decline in pancreatic β-cell function, and a poorer response to medications. Medical management in youth is focused on combining lifestyle intervention and pharmacological ...
CONTEXT: Cardiovascular disease (CVD) is a major cause of mortality in adults with type 1 diabetes. OBJECTIVE: We prospectively evaluated CVD risk factors in a large, contemporary cohort of adults with type 1 diabetes living in the United States. DESIGN: Observational study of CVD and CVD risk factors over a median of 5.3 years. SETTING: The T1D Exchange clinic network. PATIENTS: Adults (age >/= 18 years) with type 1 diabetes and without known CVD diagnosed before or at enrollment. MAIN OUTCOME ...
#1Stacey L. Simon (Anschutz Medical Campus)H-Index: 10
#2Haseeb Rahat (Anschutz Medical Campus)H-Index: 2
Last. Melanie Cree-Green (Anschutz Medical Campus)H-Index: 12
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CONTEXT: Polycystic ovary syndrome (PCOS) is a common endocrine disorder and is associated with metabolic syndrome (MS). Development of MS in PCOS is likely multifactorial and may relate to poor sleep. OBJECTIVE: The objective of this research is to investigate differences in objective markers of sleep in adolescents with obesity and PCOS with and without MS. We also aimed to examine the relationships between markers of sleep with MS markers. DESIGN: A cross-sectional study was conducted. PARTIC...
BACKGROUNDResidual C-peptide is detected in many people for years following the diagnosis of type 1 diabetes; however, the physiologic significance of low levels of detectable C-peptide is not known.METHODSWe studied 63 adults with type 1 diabetes classified by peak mixed-meal tolerance test (MMTT) C-peptide as negative ( 0.200-0.400; n = 15), or high (>0.400; n = 17). We compared the groups' glycemia from continuous glucose monitoring (CGM), beta cell secretory responses from a glucose-potentia...
#1Amy S. Shah (UC: University of Cincinnati)H-Index: 16
#2Kristen J. Nadeau (DU: University of Denver)H-Index: 30
Last. Kristen J. Nadeau (DU: University of Denver)
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The purpose of this review is to provide an update on the changing face of paediatric type 1 diabetes and type 2 diabetes. Paediatric diabetes is on the rise, with extensive research dedicated to understanding its pathophysiology, comorbidities and complications. As obesity continues to increase among all youth, differentiating between type 1 diabetes and type 2 diabetes has become increasingly difficult but remains important for optimising treatment, anticipating complications and predicting di...
1 CitationsSource