Vinay Kumar Nandicoori
Publications 43
#1Deepika Prasad (IISc: Indian Institute of Science)H-Index: 1
#2Divya AroraH-Index: 4
Last.K. Muniyappa (IISc: Indian Institute of Science)H-Index: 1
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The RecX protein has attracted considerable interest because the recX mutants exhibit multiple phenotypes associated with RecA functions. To further our understanding of the functional relationship between recA and recX, the effect of different stress treatments on their expression profiles, cell yield and viability were investigated. A significant correlation was found between the expression of Mycobacterium smegmatis recA and recX genes at different stages of growth, and in response to differe...
#1Prabhjot KaurH-Index: 3
#2Marvin Rausch (University Hospital Bonn)H-Index: 3
Last.Vinay Kumar NandicooriH-Index: 19
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The Mycobacterium tuberculosis kinase PknB is essential for growth and survival of the pathogen in vitro and in vivo. Here we report the results of our efforts to elucidate the mechanism of regulation of PknB activity. The specific residues in the PknB extracytoplasmic domain that are essential for ligand interaction and survival of the bacterium are identified. The extracytoplasmic domain interacts with mDAP-containing LipidII, and this is abolished upon mutation of the ligand-interacting resid...
3 CitationsSource
#1Shruti SrivastavaH-Index: 1
#2Madhu Babu BattuH-Index: 1
Last.Sangita MukhopadhyayH-Index: 24
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1 CitationsSource
#1Ritesh Rajesh Sevalkar (CSIR: Council of Scientific and Industrial Research)H-Index: 3
#2Divya AroraH-Index: 4
Last.Dibyendu Sarkar (CSIR: Council of Scientific and Industrial Research)H-Index: 11
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ABSTRACT A hallmark feature of Mycobacterium tuberculosis pathogenesis lies in the ability of the pathogen to survive within macrophages under a stressful environment. Thus, coordinated regulation of stress proteins is critically important for an effective adaptive response of M. tuberculosis, the failure of which results in elevated immune recognition of the tubercle bacilli with reduced survival during chronic infections. Here, we show that virulence regulator PhoP impacts the global regulatio...
#1Kavita Yadav (Manipal University)H-Index: 3
#2Prabhu Srinivas Yavvari (Indian Institute of Science Education and Research, Bhopal)H-Index: 5
Last.Avinash BajajH-Index: 22
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A major impediment to develop effective antimicrobials against Gram-negative bacteria like Salmonella is the ability of the bacteria to develop resistance against existing antibiotics and inability of the antimicrobials to clear the intracellular bacteria residing in the gastrointestinal tract. As critical balance of charge and hydrophobicity is required for effective membrane-targeting antimicrobials without causing any toxicity to mammalian cells, herein we report the synthesis and antibacteri...
1 CitationsSource
#1Richa Misra (Institute of Genomics and Integrative Biology)H-Index: 10
#2Dilip Menon (AcSIR: Academy of Scientific and Innovative Research)H-Index: 2
Last.Yogendra Singh (DU: University of Delhi)H-Index: 31
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ABSTRACT Bacterial alternative sigma factors are mostly regulated by a partner-switching mechanism. Regulation of the virulence-associated alternative sigma factor SigF of Mycobacterium tuberculosis has been an area of intrigue, with SigF having more predicted regulators than other sigma factors in this organism. Rv1364c is one such predicted regulator, the mechanism of which is confounded by the presence of both anti-sigma factor and anti-sigma factor antagonist functions in a single polypeptid...
#1Anuja C. Joshi (IISc: Indian Institute of Science)
#2Prabhjot KaurH-Index: 3
Last.Balasubramanian Gopal (IISc: Indian Institute of Science)H-Index: 18
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Extracytoplasmic function I� factors that are stress inducible are often sequestered in an inactive complex with a membrane-associated anti-I� factor. Mycobacterium tuberculosis membrane-associated anti-I� factors have a small, stable RNA gene A (ssrA)-like degron for targeted proteolysis. Interaction between the unfoldase, ClpX, and a substrate with an accessible degron initiates energy-dependent proteolysis. Four anti-I� factors with a mutation in the degron provided a set of natural substrate...
#1Ashima BhaskarH-Index: 11
Last.Vinay Kumar NandicooriH-Index: 19
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#1Mehak Zahoor KhanH-Index: 2
#2Prabhjot KaurH-Index: 3
Last.Vinay Kumar NandicooriH-Index: 19
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5 CitationsSource