Monique van der Voet
Radboud University Nijmegen
Publications 21
#1Benjamin Harich (Radboud University Nijmegen)H-Index: 4
#2Marieke Klein (Radboud University Nijmegen)H-Index: 1
Last.Barbara Franke (Radboud University Nijmegen)H-Index: 76
view all 8 authors...
#1Marieke KleinH-Index: 10
#2Euginia L. SinggihH-Index: 1
Last.Barbara FrankeH-Index: 76
view all 12 authors...
#1Benjamin Harich (Radboud University Nijmegen)H-Index: 4
#2Monique van der Voet (Radboud University Nijmegen)H-Index: 12
Last.Barbara Franke (Radboud University Nijmegen)H-Index: 76
view all 7 authors...
Aim: Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable psychiatric disorder. The objective of this study was to define ADHD-associated candidate genes, and their associated molecular modules and biological themes, based on the analysis of rare genetic variants. Methods: We combined data from 11 published copy number variation (CNV) studies in 6176 individuals with ADHD and 25026 controls and prioritized genes by applying an integrative strategy based on criteria including rec...
#1Marieke Klein (Radboud University Nijmegen)H-Index: 10
#2Euginia L. Singgih (Radboud University Nijmegen)H-Index: 1
Last.Barbara Franke (Radboud University Nijmegen)H-Index: 76
view all 13 authors...
Objective: Attention-Deficit/Hyperactivity Disorder (ADHD) is a common, highly heritable neuropsychiatric disorder. ADHD often co-occurs with Intellectual Disability (ID), and shared overlapping genetics have been suggested. This study aimed to identify novel ADHD genes by investigating whether genes carrying rare mutations linked to ID contribute to ADHD risk through common genetic variants. Validation and characterization of candidates were performed using Drosophila melanogaster. Method: Comm...
#1Marieke KleinH-Index: 10
#2Benjamin HarichH-Index: 4
Last.Barbara FrankeH-Index: 76
view all 8 authors...
#1Celia Zazo Seco (Radboud University Nijmegen)H-Index: 7
#2Anna Castells-Nobau (Radboud University Nijmegen)H-Index: 8
Last.Saima Siddiqi (Brazilian Institute of Geography and Statistics)H-Index: 8
view all 30 authors...
A consanguineous family from Pakistan was ascertained with a novel deafness-dystonia syndrome with motor regression, ichthyosis-like features and signs of sensory neuropathy. By applying a combined strategy of linkage analysis and whole-exome sequencing in the presented family, a homozygous nonsense mutation, c.4G>T (p.Glu2*), in FITM2 was identified. FITM2 and its paralog FITM1 constitute an evolutionary conserved protein family involved in partitioning of triglycerides into cellular lipid drop...
5 CitationsSource
#1Thijs KoormanH-Index: 5
#2Diana KlompstraH-Index: 2
Last.Mike BoxemH-Index: 21
view all 10 authors...
The establishment of cell polarity is an essential process for the development of multicellular organisms and the functioning of cells and tissues. Here, we combine large-scale protein interaction mapping with systematic phenotypic profiling to study the network of physical interactions that underlies polarity establishment and maintenance in the nematode Caenorhabditis elegans. Using a fragment-based yeast two-hybrid strategy, we identified 439 interactions between 296 proteins, as well as the ...
9 CitationsSource
#1Monica AasH-Index: 20
Last.Lynn E. DeLisiH-Index: 78
view all 29 authors...
The XXII World Congress of Psychiatric Genetics, sponsored by the International Society of Psychiatric Genetics, took place in Copenhagen, Denmark, on 12-16 October 2014. A total of 883 participants gathered to discuss the latest findings in the field. The following report was written by student and postdoctoral attendees. Each was assigned one or more sessions as a rapporteur. This manuscript represents topics covered in most, but not all of the oral presentations during the conference, and con...
#1Anne Gregor (FAU: University of Erlangen-Nuremberg)H-Index: 6
#2Jamie M. Kramer (Radboud University Nijmegen)H-Index: 17
Last.Christiane Zweier (FAU: University of Erlangen-Nuremberg)H-Index: 35
view all 9 authors...
Glycoprotein M6A (GPM6A) is a neuronal transmembrane protein of the PLP/DM20 (proteolipid protein) family that associates with cholesterol-rich lipid rafts and promotes filopodia formation. We identified a de novo duplication of the GPM6A gene in a patient with learning disability and behavioral anomalies. Expression analysis in blood lymphocytes showed increased GPM6A levels. An increase of patient-derived lymphoblastoid cells carrying membrane protrusions supports a functional effect of this d...
14 CitationsSource
#1Amit Lotan (HUJI: Hebrew University of Jerusalem)H-Index: 8
#2Michaela Fenckova (Radboud University Nijmegen)H-Index: 10
Last.Monique van der Voet (Radboud University Nijmegen)H-Index: 12
view all 7 authors...
Major neuropsychiatric disorders are highly heritable, with mounting evidence suggesting that these disorders share overlapping sets of molecular and cellular underpinnings. In the current article we systematically test the degree of genetic commonality across six major neuropsychiatric disorders—attention deficit hyperactivity disorder, anxiety disorders, autistic spectrum disorders, bipolar disorder, major depressive disorder and schizophrenia. We curated a well-vetted list of genes based on l...
48 CitationsSource