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Marko Šestan
University of Rijeka
8Publications
4H-index
327Citations
Publications 8
Newest
#1Felix M. Wensveen (University of Rijeka)H-Index: 18
#2Marko Šestan (University of Rijeka)H-Index: 4
Last.Bojan Polić (University of Rijeka)H-Index: 26
view all 4 authors...
Source
#1Vedrana Jelenčić (University of Rijeka)H-Index: 5
#2Marko Šestan (University of Rijeka)H-Index: 4
Last.Bojan Polić (University of Rijeka)H-Index: 26
view all 12 authors...
The activation of natural killer (NK) cells depends on a change in the balance of signals from inhibitory and activating receptors. The activation threshold values of NK cells are thought to be set by engagement of inhibitory receptors during development. Here, we found that the activating receptor NKG2D specifically set the activation threshold for the activating receptor NCR1 through a process that required the adaptor DAP12. As a result, NKGD2-deficient (Klrk1−/−) mice controlled tumors and c...
4 CitationsSource
#1Marko Šestan (University of Rijeka)H-Index: 4
#2Sonja Marinović (University of Rijeka)H-Index: 2
Last.Bojan Polić (University of Rijeka)H-Index: 26
view all 11 authors...
Summary Pro-inflammatory cytokines of a T helper-1-signature are known to promote insulin resistance (IR) in obesity, but the physiological role of this mechanism is unclear. It is also unknown whether and how viral infection induces loss of glycemic control in subjects at risk for developing diabetes mellitus type 2 (DM2). We have found in mice and humans that viral infection caused short-term systemic IR. Virally-induced interferon-γ (IFN-γ) directly targeted skeletal muscle to downregulate th...
10 CitationsSource
#1Felix M. WensveenH-Index: 18
#2Vedrana JelenčićH-Index: 5
Last.Bojan PolićH-Index: 2
view all 11 authors...
#1Felix M. Wensveen (University of Rijeka)H-Index: 18
#2Sonja Valentić (University of Rijeka)H-Index: 3
Last.Bojan Polić (University of Rijeka)H-Index: 26
view all 5 authors...
Obesity is associated with the accumulation of pro-inflammatory cells in visceral adipose tissue (VAT), which is an important underlying cause of insulin resistance and progression to diabetes mellitus type 2 (DM2). Although the role of pro-inflammatory cytokines in disease development is established, the initiating events leading to immune cell activation remain elusive. Lean adipose tissue is predominantly populated with regulatory cells, such as eosinophils and type 2 innate lymphocytes. Thes...
109 CitationsSource
#1Felix M. Wensveen (University of Rijeka)H-Index: 18
#2Sonja Valentić (University of Rijeka)H-Index: 3
Last.Bojan Polić (University of Rijeka)H-Index: 26
view all 5 authors...
Adipose tissue provides the body with a storage depot of nutrients that is drained during times of starvation and replenished when food sources are abundant. As such, it is the primary sensor for nutrient availability in the milieu of an organism, which it communicates to the body through the excretion of hormones. Adipose tissue regulates a multitude of body functions associated with metabolism, such as gluconeogenesis, feeding and nutrient uptake. The immune system forms a vital layer of prote...
18 CitationsSource
#1Felix M. Wensveen (University of Rijeka)H-Index: 18
#2Vedrana Jelenčić (University of Rijeka)H-Index: 5
Last.Bojan Polić (University of Rijeka)H-Index: 26
view all 13 authors...
Visceral adipose tissue (VAT) inflammation drives obesity-induced insulin resistance. Polic and colleagues show that VAT NK cells sense obesity-induced adipose tissue stress and drive inflammation through the production of interferon-γ.
186 CitationsSource
#1Felix M. WensveenH-Index: 18
#2Vedrana JelenčićH-Index: 5
Last.Bojan PolićH-Index: 26
view all 11 authors...
Debljina danas predstavlja znacajan medicinski izazov u svijetu zbog velike zahvacenosti ljudske populacije i brojnih zdravstvenih komplikacija koje uzrokuje. Rezistencija na inzulin i posljedicni razvoj secerne bolesti tipa 2 su među najcescim komplikacijama debljine, a kronicna upala masnog tkiva niskog intenziteta smatra se kljucnim događajem koji sve to povezuje.
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