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Benjamin J. Glasser
Rutgers University
ParticleChemistryFluidized bedChromatographyClassical mechanics
130Publications
30H-index
2,481Citations
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Publications 127
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#1Hao Chen (RU: Rutgers University)H-Index: 6
#2Emily Diep (RU: Rutgers University)H-Index: 1
Last. Benjamin J. Glasser (RU: Rutgers University)H-Index: 30
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#1Clara Hartmanshenn (RU: Rutgers University)H-Index: 2
#2Johannes Khinast (Graz University of Technology)H-Index: 30
Last. Benjamin J. Glasser (RU: Rutgers University)H-Index: 30
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#1Anusha V. Noorithaya (RU: Rutgers University)
#2Cody Bishop (RU: Rutgers University)H-Index: 2
Last. Benjamin J. Glasser (RU: Rutgers University)H-Index: 30
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Abstract Supported catalysts are widely used in many industries. Manufacturing these catalysts is complex and manufacturing processes are influenced by many interdependent parameters. Although the performance and activity of catalysts are the most critical properties, their structures and design are also critical to their effectiveness. Previous work has shown that drying of catalysts can lead to the redistribution of metal and this in turn can affect the performance of the catalyst. At the same...
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Purpose In this study, an active pharmaceutical ingredient (API) was impregnated onto a mesoporous carrier (excipient) in a fluidized bed. Impregnating APIs in porous carriers has the potential to simplify the drug substance development process and leads to the elimination of the blending and granulation unit operations. Impregnation and drying occur simultaneously in fluidized-bed impregnation, and this method precludes several challenges encountered in other impregnation methods. Furthermore, ...
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#1Plamen I. Grigorov (RU: Rutgers University)H-Index: 2
#2Fernando J. Muzzio (RU: Rutgers University)H-Index: 52
Last. Benjamin J. Glasser (RU: Rutgers University)H-Index: 30
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Abstract Impregnation of active pharmaceutical ingredients (APIs) onto porous excipients offers several advantages to solid dosage pharmaceutical preparation over conventional formulation methods. Previous work has successfully introduced fluidized bed (FB) impregnation of APIs onto porous carriers as a robust manufacturing process with numerous benefits (easy to implement, excellent blend uniformity and dissolution kinetics, stabilization of amorphous APIs). This study aims to develop a simple,...
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#1Ingrid J. Paredes (RU: Rutgers University)H-Index: 2
#2Bereket Yohannes (RU: Rutgers University)H-Index: 9
Last. Alberto M. Cuitiño (RU: Rutgers University)H-Index: 30
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Abstract The rotary kiln is an essential device in chemical and metallurgical industries, with applications in a wide range of solids manufacturing processes. In particular, in the preparation of industrial chemical catalysts, the kiln has become a popular reactor for continuous calcination of catalysts ranging from millimeter-sized extrudates to micron-sized powders. As granular and powder flow behaviors are difficult to characterize, the design and scale-up of rotary calcination processes are ...
1 CitationsSource
#1Nicolin Govender (University of Surrey)H-Index: 7
#2Raj K. Rajamani (UofU: University of Utah)H-Index: 22
Last. Benjamin J. Glasser (RU: Rutgers University)H-Index: 30
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Abstract The reduction in particle size of raw materials using grinding mills is an energy and cost intensive task. Optimization of grinding processes is not trivial as obtaining experimental information is extremely difficult due to the harsh environment. Thus, computational modeling is the most feasible option for obtaining information on the dynamics of the media. However, the computational cost of modeling each particle is high, resulting in the shape of the media being approximated by simpl...
3 CitationsSource
#1Hao Chen (RU: Rutgers University)H-Index: 6
#2Subham Rustagi (RU: Rutgers University)H-Index: 1
Last. Benjamin J. Glasser (RU: Rutgers University)H-Index: 30
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Abstract The fluidized bed drying unit operation is extensively used in the pharmaceutical industry. However, there are still many unanswered questions with respect to scaling up fluidized bed drying operations. In this study, a scaling method for the fluidized bed drying process was investigated to predict drying under new operating conditions based on existing experimental data. A normalization scaling factor was implemented based on the ratio of operating conditions – heating air temperature,...
1 CitationsSource
#1Veerakiet Boonkanokwong (RU: Rutgers University)H-Index: 1
#2Rohan P. Frank (RU: Rutgers University)
Last. Benjamin J. Glasser (RU: Rutgers University)H-Index: 30
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Abstract The torque and power needed to drive an impeller are important quantities that can indicate flow behavior and can be used to control processes, especially mixing and granulation in the pharmaceutical industry. In this study, experiments were conducted on monodisperse spherical glass beads flowing in a cylindrical bladed mixer agitated by an impeller. The impeller torque was measured using a rotating platform and a data recording device, and the power draw for the motor driving the impel...
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#1Nicolin Govender (University of Surrey)H-Index: 7
#2Daniel N. Wilke (University of Pretoria)H-Index: 10
Last. Benjamin J. Glasser (RU: Rutgers University)H-Index: 30
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Mixing of particulate systems is an important process to achieve uniformity, in particular pharmaceutical processes that requires the same amount of active ingredient per tablet. Several mixing processes exist, this study is concerned with mechanical mixing of crystalline particles using a four-blade mixer. Although numerical investigations of mixing using four-blades have been conducted, the simplification of particle shape to spherical or rounded superquadric particle systems is universal acro...
8 CitationsSource
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