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Denise L. Doolan
Australian Institute of Tropical Health and Medicine
189Publications
44H-index
8,218Citations
Publications 183
Newest
#1Zhiwei LiuH-Index: 8
#2Ruth F. Jarrett (Glas.: University of Glasgow)H-Index: 37
Last.Anna E. CoghillH-Index: 13
view all 17 authors...
1 CitationsSource
Summary Extreme diversity of the major Plasmodium falciparum antigen, PfEMP1, poses a barrier to identifying targets of immunity to malaria. Here, we used protein microarrays containing hundreds of variants of the DBLα domain of PfEMP1 to cover the diversity of Papua New Guinean (PNG) parasites. Probing the plasma of a longitudinal cohort of malaria-exposed PNG children showed that group 2 DBLα antibodies were moderately associated with a lower risk of uncomplicated malaria, whereas individual v...
1 CitationsSource
#1Carla ProiettiH-Index: 10
#2Lutz KrauseH-Index: 37
Last.Denise L. DoolanH-Index: 44
view all 11 authors...
Source
#1Anna E. CoghillH-Index: 13
#2Carla Proietti (Australian Institute of Tropical Health and Medicine)H-Index: 1
Last.Sam M. MbulaiteyeH-Index: 27
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Background:The discovery of Epstein-Barr virus (EBV) in Burkitt lymphoma (BL) tumors represented the first link between a virus and cancer in humans, but the underlying role of this virus in endemic BL remains unclear. Nearly all children in BL-endemic areas are seropositive for EBV, but only a small percentage develops disease. Variation in EBV-directed immunity could be an explanatory co-factor. Methods:We examined serum from 150 BL cases and 150 controls using a protein microarry that measure...
1 CitationsSource
#1Claire Loiseau (Australian Institute of Tropical Health and Medicine)H-Index: 1
#2Martha M. Cooper (Australian Institute of Tropical Health and Medicine)H-Index: 1
Last.Denise L. Doolan (Australian Institute of Tropical Health and Medicine)H-Index: 44
view all 3 authors...
Source
#1Martha M. Cooper (Australian Institute of Tropical Health and Medicine)H-Index: 1
#2Claire Loiseau (Australian Institute of Tropical Health and Medicine)H-Index: 1
Last.Denise L. Doolan (Australian Institute of Tropical Health and Medicine)H-Index: 44
view all 3 authors...
The mechanisms underlying acquisition of naturally acquired immunity to malaria are poorly understood. In this issue of Immunity, Tran and colleagues (2019) demonstrate that systems immunology is a powerful tool to decipher molecular and cellular components contributing to this immunity.
Source
#1Denise L. Doolan (Australian Institute of Tropical Health and Medicine)H-Index: 44
#2Ted M. Ross (UGA: University of Georgia)H-Index: 38
Source
#1Michelle J. Boyle (Burnet Institute)H-Index: 16
#2Jo-Anne Chan (Burnet Institute)H-Index: 10
Last.James G. Beeson (Monash University)H-Index: 56
view all 28 authors...
Most studies on human immunity to malaria have focused on the roles of immunoglobulin G (IgG), whereas the roles of IgM remain undefined. Analyzing multiple human cohorts to assess the dynamics of malaria-specific IgM during experimentally induced and naturally acquired malaria, we identified IgM activity against blood-stage parasites. We found that merozoite-specific IgM appears rapidly in Plasmodium falciparum infection and is prominent during malaria in children and adults with lifetime expos...
4 CitationsSource
#1Zhiwei LiuH-Index: 8
#2Kelly J. YuH-Index: 17
Last.Allan HildesheimH-Index: 85
view all 19 authors...
ABSTRACT IgA antibodies targeting Epstein-Barr virus (EBV) have been proposed for screening for nasopharyngeal carcinoma (NPC). However, methods differ, and the antigens used in these assays differ considerably between laboratories. To enable formal comparisons across a range of established EBV serology assays, we created a panel of 66 pooled serum samples and 66 pooled plasma samples generated from individuals with a broad range of IgA antibody levels. Aliquots from these panels were distribute...
Source
#1Zhiwei LiuH-Index: 8
#2Kelly J. YuH-Index: 17
Last.Allan HildesheimH-Index: 85
view all 19 authors...
Background IgA antibodies targeting Epstein-Barr virus (EBV) have been proposed for screening for nasopharyngeal carcinoma (NPC). However, methods vary, and antigens used in these assays differ considerably between laboratories. Methods To enable formal comparisons across a range of established EBV serology assays, we created a panel of 66 pooled serum and 66 pooled plasma samples generated from individuals with a broad range of IgA antibody levels. Aliquots from these panels were distributed to...
Source
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