Chandni Hindocha
University College London
PsychiatryPsychologyCannabidiolCannabisEffects of cannabis
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Publications 48
#1Claire Mokrysz (UCL: University College London)H-Index: 10
#2Natacha D. C. Shaban (UCL: University College London)H-Index: 3
Last. Cja Morgan (University of Exeter)H-Index: 36
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BACKGROUND: Acute cannabis administration can produce transient psychotic-like effects in healthy individuals. However, the mechanisms through which this occurs and which factors predict vulnerability remain unclear. We investigate whether cannabis inhalation leads to psychotic-like symptoms and speech illusion; and whether cannabidiol (CBD) blunts such effects (study 1) and adolescence heightens such effects (study 2). METHODS: Two double-blind placebo-controlled studies, assessing speech illus...
Abstract Acute and chronic exposure to cannabis and its main psychoactive component, 9-tetrahydrocannabinol (THC), is associated with changes in brain function and cerebral blood flow (CBF). We therefore sought to systematically review the literature on the effects of THC on CBF following PRISMA guidelines. Studies assessing the acute and chronic effects of THC on CBF, perfusion and volume were searched in the PubMed database between January 1972 and June 2019. We included thirty-four studies, w...
#1Chandni Hindocha (UCLH: University College Hospital)H-Index: 13
#1C. Hindocha (UCLH: University College Hospital)
Last. M. A. P. Bloomfield (Camden and Islington NHS Foundation Trust)H-Index: 1
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AbstractObjectives: Posttraumatic stress disorder (PTSD) is a potentially debilitating mental health problem. There has been a recent surge of interest regarding the use of cannabinoids in the trea...
1 CitationsSource
#1Tom P. Freeman (University of Bath)H-Index: 22
#2Cja Morgan (University of Exeter)H-Index: 36
Last. Chandni Hindocha (UCL: University College London)H-Index: 13
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Alternative trial designs and patient registries can rapidly generate robust data on efficacy and safety
1 CitationsSource
#1Abigail M. Freeman (UCL: University College London)H-Index: 2
#2Katherine Petrilli (UCL: University College London)H-Index: 1
Last. Tom P. Freeman (UCL: University College London)H-Index: 22
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Abstract The recent liberalisation of cannabis regulation has increased public and scientific debate about its potential benefits and risks. A key focus has been the extent to which cannabidiol (CBD) might influence the acute effects of delta-9-tetrahydrocannabinol (THC), but this has never been reviewed systematically. In this systematic review of how CBD influences the acute effects of THC we identified 16 studies involving 466 participants. Ten studies were judged at low risk of bias. The fin...
4 CitationsSource
#1H. Valerie Curran (UCL: University College London)H-Index: 4
#2Chandni Hindocha (UCL: University College London)H-Index: 13
Last. Tom P. Freeman (UCL: University College London)H-Index: 22
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BACKGROUND: Changes in cannabis regulation globally make it increasingly important to determine what predicts an individual's risk of experiencing adverse drug effects. Relevant studies have used diverse self-report measures of cannabis use, and few include multiple biological measures. Here we aimed to determine which biological and self-report measures of cannabis use predict cannabis dependency and acute psychotic-like symptoms. METHOD: In a naturalistic study, 410 young cannabis users were a...
7 CitationsSource
#1H. Valerie CurranH-Index: 43
#2Chandni HindochaH-Index: 13
Last. Tom P. FreemanH-Index: 22
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#1Matthew B. Wall (UCL: University College London)H-Index: 19
#2Rebecca A. Pope (UCL: University College London)H-Index: 4
Last. Valerie Curran (UCL: University College London)H-Index: 8
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Background:Two major constituents of cannabis are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is the main psychoactive component; CBD may buffer the user against the harmful effects of THC.Aims:We examined the effects of two strains of cannabis and placebo on the human brain’s resting-state networks using fMRI.Methods:Seventeen healthy volunteers (experienced with cannabis, but not regular users) underwent three drug treatments and scanning sessions. Treatments were cannabis contain...
5 CitationsSource
#1Chandni Hindocha (UCL: University College London)H-Index: 13
#2Tom P. FreemanH-Index: 22
Last. H. Valerie Curran (UCL: University College London)H-Index: 43
view all 8 authors...
1 CitationsSource
#1Tom P. FreemanH-Index: 22
#2Chandni Hindocha (UCL: University College London)H-Index: 13
Last. Michael A. P. BloomfieldH-Index: 10
view all 4 authors...
### What you need to know Until recently, cannabis and its derivatives were widely restricted under legislation which stated they had no medical value and carried a substantial risk of misuse. Policy is rapidly changing, and cannabis can now be prescribed for medicinal use in many countries, including the UK. This provides important new opportunities for treating patients although these need to be weighed up against potential risks. Several different medicinal products exist, with contrasting me...
8 CitationsSource