Tibor Nadasdy
Ohio State University
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Publications 119
#1Elisa Delbarba (University of Brescia)H-Index: 3
#2Maddalena Marasa (CUMC: Columbia University Medical Center)H-Index: 11
Last. Jonathan J. Hogan (UPenn: University of Pennsylvania)H-Index: 10
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Abstract Introduction Glomerular diseases are characterized by variable disease activity over many years. We aimed to analyze the relationship between clinical disease activity and duration of glomerular disease. Methods Disease activity in adults with chronic minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and immunoglobulin A nephropathy (IgAN; first diagnostic biopsy >5 years before enrollment; Of Longstanding Disease (OLD) cohort, N=256) followed at Columb...
#1Edward Calomeni (OSU: Ohio State University)H-Index: 10
#2Anjali A. Satoskar (OSU: Ohio State University)H-Index: 24
Last. Tibor Nadasdy (OSU: Ohio State University)H-Index: 31
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1 CitationsSource
#1Dharmendra Jain (U of C: University of Chicago)H-Index: 1
#2Amer Rajab (OSU: Ohio State University)H-Index: 12
Last. Ronald P. Pelletier (OSU: Ohio State University)H-Index: 30
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Active antibody-mediated rejection (AMR) is a potentially devastating complication and consistently effective treatment remains elusive. We hypothesized that the reversal of acute AMR requires rapid elimination of antibody-secreting plasma cells (PC) with a proteasome inhibitor, bortezomib, followed by the sustained inhibition of PC generation with CTLA4-Ig or belatacept (B/B). We show in mice that B/B therapy selectively depleted mature PC producing donor-specific antibodies (DSA) and reduced D...
Context.— Calcium oxalate (CaOx) deposits in a kidney biopsy specimen can be seen in acute or chronic kidney injury and in oxalate nephropathy. Although no established cutoff criteria to diagnose o...
#1Anjali A. Satoskar (OSU: Ohio State University)H-Index: 24
#2Samir Parikh (OSU: Ohio State University)H-Index: 10
Last. Tibor Nadasdy (OSU: Ohio State University)H-Index: 31
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For over a century, acute ‘post-streptococcal glomerulonephritis’ (APSGN) was the prototypical form of bacterial infection-associated glomerulonephritis, typically occurring after resolution of infection and a distinct infection-free latent period. Other less common forms of infection-associated glomerulonephritides resulted from persistent bacteraemia in association with subacute bacterial endocarditis and shunt nephritis. However, a major paradigm shift in the epidemiology and bacteriology of ...
5 CitationsSource
A subset of patients with Ataxia-Telangiectasia (A-T) have dramatically reduced levels of IgG, IgA, and IgE with retained or elevated IgM levels. Several reports suggest that these A-T patients with a “hyper-IgM phenotype” (HIgM) suffer more clinical immunologic consequences than other A-T patients. The immunopathologic mechanism driving this phenomenon is unknown, making it difficult to predict response to immunomodulatory therapy. We describe an A-T patient with HIgM who underwent tumor necros...
#1Francesca Cottini (OSU: Ohio State University)H-Index: 12
#2Cherri Bott (OSU: Ohio State University)H-Index: 4
Last. Don M. Benson (OSU: Ohio State University)H-Index: 34
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#1Clarissa A. Cassol (OSU: Ohio State University)H-Index: 7
#1Clarissa A. Cassol (OSU: Ohio State University)
Last. Anjali A. Satoskar (OSU: Ohio State University)H-Index: 24
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BACKGROUND: Primary immunoglobulin A nephropathy (IgAN) is characterized by IgA1-dominant or codominant glomerular deposits, postulated to be galactose deficient (Gd). However, glomerular IgA deposition can also occur in nonrenal diseases such as liver cirrhosis, psoriasis and inflammatory bowel disease ('secondary IgAN') or be an incidental finding in biopsies with other pathologies. A glomerulonephritis resembling IgAN can develop in patients with bacterial, mainly staphylococcal infections [s...
2 CitationsSource
#1Clarissa A. Cassol (OSU: Ohio State University)
#2Anjali A. Satoskar (OSU: Ohio State University)H-Index: 24
Last. Sergey V. Brodsky (OSU: Ohio State University)H-Index: 24
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Abstract Introduction Novel anti-cancer therapies include anti-program death-1 (PD-1) and anti-program death ligand -1 (PD-L1) drugs. These novel medications have side-effects in different organs, including the kidney. The most common adverse effect in the kidney is acute interstitial nephritis (AIN). No diagnostic criteria are available to distinguish between AIN associated with anti-PD-1 therapy from other AINs. Methods Kidney biopsies from patients on anti-PD-1 therapy were stained with antib...