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Jen Chieh Chuang
University of Texas Southwestern Medical Center
32Publications
17H-index
1,841Citations
Publications 32
Newest
#1Deepali Gupta (UTSW: University of Texas Southwestern Medical Center)H-Index: 1
#2Jen Chieh Chuang (UTSW: University of Texas Southwestern Medical Center)H-Index: 17
Last.Jeffrey M. Zigman (UTSW: University of Texas Southwestern Medical Center)H-Index: 44
view all 8 authors...
The ghrelin system is a key component of the mood and metabolic responses to chronic psychosocial stress. For example, circulating acyl-ghrelin rises in several rodent and human stress models, administered acyl-ghrelin induces antidepressant-like behavioral responses in mice, and mice with deleted ghrelin receptors (GHSRs) exhibit exaggerated depressive-like behaviors, changed eating behaviors, and altered metabolism in response to chronic stress. However, the mechanisms mediating stress-induced...
#1Lilja Kjalarsdottir (UTSW: University of Texas Southwestern Medical Center)H-Index: 2
#2Sarah A. Tersey (IU: Indiana University)H-Index: 17
Last.Joyce J. RepaH-Index: 51
view all 7 authors...
Abstract Aim Vitamin D deficiency in rodents negatively affects glucose-stimulated insulin secretion (GSIS) and human epidemiological studies connect poor vitamin D status with type 2 diabetes. Previous studies performed primarily in rat islets have shown that vitamin D can enhance GSIS. However the molecular pathways linking vitamin D and insulin secretion are currently unknown. Therefore, experiments were undertaken to elucidate the transcriptional role(s) of the vitamin D receptor (VDR) in is...
#1Dieter LütjohannH-Index: 44
#2Adam M. Lopez (UTSW: University of Texas Southwestern Medical Center)H-Index: 7
Last.Stephen D. Turley (UTSW: University of Texas Southwestern Medical Center)H-Index: 29
view all 5 authors...
#1Adam M. Lopez (UTSW: University of Texas Southwestern Medical Center)H-Index: 7
#2Jen Chieh Chuang (UTSW: University of Texas Southwestern Medical Center)H-Index: 17
Last.Stephen D. TurleyH-Index: 29
view all 3 authors...
Abstract Although only a small proportion of cholesterol in the body is esterified, in several diseases marked expansion of the esterified cholesterol (EC) pool occurs. These include Wolman disease (WD) and Cholesteryl Ester Storage Disease (CESD) which both result from mutations in LIPA, the gene that encodes lysosomal acid lipase (LAL). The respective contributions that our three cholesterol esterifying enzymes make to EC production, especially in disorders like CESD, are not well defined. The...
#1Jen Chieh Chuang (UTSW: University of Texas Southwestern Medical Center)H-Index: 17
#2Adam M. Lopez (UTSW: University of Texas Southwestern Medical Center)H-Index: 7
Last.Stephen D. TurleyH-Index: 29
view all 3 authors...
Abstract Esterified cholesterol (EC) and triglycerides, contained within lipoproteins taken up by cells, are hydrolysed by lysosomal acid lipase (LAL) in the late endosomal/lysosomal (E/L) compartment. The resulting unesterified cholesterol (UC) is transported via Niemann-Pick type C2 and C1 into the cytosolic compartment where it enters a putative pool of metabolically active cholesterol that is utilized in accordance with cellular needs. Loss-of-function mutations in LIPA, the gene encoding LA...
#1Adam M. Lopez (UTSW: University of Texas Southwestern Medical Center)H-Index: 7
#2Jen Chieh Chuang (UTSW: University of Texas Southwestern Medical Center)H-Index: 17
Last.Stephen D. Turley (UTSW: University of Texas Southwestern Medical Center)H-Index: 29
view all 3 authors...
#1Adam M. Lopez (UTSW: University of Texas Southwestern Medical Center)H-Index: 7
#2Jen Chieh Chuang (UTSW: University of Texas Southwestern Medical Center)H-Index: 17
Last.Stephen D. TurleyH-Index: 29
view all 4 authors...
Mutations in the X-linked gene methyl-CpG-binding protein 2 (MECP2) are the principal cause of Rett syndrome, a progressive neurodevelopmental disorder afflicting 1 in 10,000 to 15,000 females. Studies using hemizygous Mecp2 mouse models have revealed disruptions to some aspects of their lipid metabolism including a partial suppression of cholesterol synthesis in the brains of mature Mecp2 mutants. The present studies investigated whether this suppression is evident from early neonatal life, or ...
#1Adam M. Lopez (UTSW: University of Texas Southwestern Medical Center)H-Index: 7
#2Jen Chieh Chuang (UTSW: University of Texas Southwestern Medical Center)H-Index: 17
Last.Stephen D. TurleyH-Index: 29
view all 7 authors...
In most organs, the bulk of cholesterol is unesterified, although nearly all possess a varying capability of esterifying cholesterol through the action of either sterol O -acyltransferase (SOAT) 1 or, in the case of hepatocytes and enterocytes, SOAT2. Esterified cholesterol (EC) carried in plasma lipoproteins is hydrolyzed by lysosomal acid lipase (LAL) when they are cleared from the circulation. Loss-of-function mutations in LIPA, the gene that encodes LAL, result in Wolman disease or cholester...
#1Ryan D. Jones (UTSW: University of Texas Southwestern Medical Center)H-Index: 3
#2Adam M. Lopez (University of Texas at Austin)H-Index: 7
Last.Stephen D. Turley (University of Texas at Austin)H-Index: 29
view all 7 authors...
Mice deficient in cholesterol 7α-hydroxylase (Cyp7a1) have a diminished bile acid pool (BAP) and therefore represent a useful model for investigating the metabolic effects of restoring the pool with a specific BA. Previously we carried out such studies in Cyp7a1−/− mice fed physiological levels of cholic acid (CA) and achieved BAP restoration, along with an increased CA enrichment, at a dietary level of just 0.03% (w/w). Here we demonstrate that in Cyp7a1−/− mice fed chenodeoxycholic acid (CDCA)...
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