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Sara Lindstroem
University of Washington
Genome-wide association studyCancerProstate cancerBreast cancerMedicine
209Publications
46H-index
8,037Citations
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Publications 219
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#1Siddhartha Kar (UoB: University of Bristol)H-Index: 15
#2Sara Lindstroem (UW: University of Washington)H-Index: 46
Last. Jenny Chang-Claude (DKFZ: German Cancer Research Center)H-Index: 92
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We report a meta-analysis of breast, prostate, ovarian, and endometrial cancer genome-wide association data (effective sample size: 237,483 cases/317,006 controls). This identified 465 independent lead variants (P 1Mb from previously identified risk loci for the four cancers and an additional 23 lead variant-cancer associations were novel for one of the cancers. Bayesian models supported pleiotropic effects involving at least two cancers at 222/465 lead variants in 118/192 regions. Gene-level as...
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#1Peter KraftH-Index: 105
Last. Sara LindstroemH-Index: 46
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#1Pooja Middha Kapoor (DKFZ: German Cancer Research Center)H-Index: 1
#2Nasim Mavaddat (University of Cambridge)H-Index: 14
Last. Qin Wang (University of Cambridge)H-Index: 37
view all 143 authors...
Combining polygenic risk score (PRS) with classical risk factors could improve accuracy of breast cancer prediction models. We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors in women of European ancestry, using 72,284 cases and 80,354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression, and a newly developed case-only method, for breast cancer risk overal...
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#1Thomas R. Austin (UW: University of Washington)H-Index: 5
#2Bharath Ambale Venkatesh (Johns Hopkins University)H-Index: 16
Last. Susan R. Heckbert (UW: University of Washington)H-Index: 93
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#1Helian Feng (Harvard University)H-Index: 3
Last. Antonis C. AntoniouH-Index: 60
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Previous transcriptome-wide association studies (TWAS) have identified breast cancer risk genes by integrating data from expression quantitative loci and genome-wide association studies (GWAS), but analyses of breast cancer subtype-specific associations have been limited. In this study, we conducted a TWAS using gene expression data from GTEx and summary statistics from the hitherto largest GWAS meta-analysis conducted for breast cancer overall, and by estrogen receptor subtypes (ER+ and ER-). W...
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#1Pooja Middha Kapoor (DKFZ: German Cancer Research Center)H-Index: 1
#2Sara Lindstroem (UW: University of Washington)H-Index: 46
Last. Argyrios Ziogas (UCI: University of California, Irvine)H-Index: 62
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Background Previous gene-environment interaction studies of breast cancer risk have provided sparse evidence of interactions. Using the largest available dataset to date, we performed a comprehensive assessment of potential effect modification of 205 common susceptibility variants by 13 established breast cancer risk factors, including replication of previously reported interactions. Methods Analyses were performed using 28 176 cases and 32 209 controls genotyped with iCOGS array and 44 109 case...
3 CitationsSource
Purpose The relationship of allergic diseases, such as asthma, hay fever, and eczema, with cancer is under debate. Observational studies have reported conflicting findings, but such studies are susceptible to confounding and reverse causation. Understanding the potential role of allergy in carcinogenesis may shed new light on the biological mechanisms underpinning intrinsic immunity and cancer.
2 CitationsSource
#1Xia Jiang (KI: Karolinska Institutet)H-Index: 6
#1Xia Jiang (KI: Karolinska Institutet)H-Index: 12
Last. Sara Lindstroem (UW: University of Washington)H-Index: 46
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#1Elias Allara (University of Cambridge)H-Index: 9
#2G. Morani (UNIPV: University of Pavia)
Last. Stephen Burgess (University of Cambridge)H-Index: 43
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Background - Evidence from randomized trials has shown that therapies that lower low-density lipoprotein (LDL)-cholesterol and triglycerides reduce coronary artery disease (CAD) risk. However, ther...
3 CitationsSource
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