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Christine E. Schnitzler
Whitney Laboratory for Marine Bioscience
33Publications
16H-index
1,530Citations
Publications 33
Newest
Published in Science41.04
Stefan Siebert8
Estimated H-index: 8
(UC Davis: University of California, Davis),
Jeffrey A. Farrell8
Estimated H-index: 8
(Harvard University)
+ -3 AuthorsCelina E. Juliano13
Estimated H-index: 13
(UC Davis: University of California, Davis)
INTRODUCTION The cnidarian polyp Hydra undergoes continual self-renewal and is capable of whole-body regeneration from a small piece of tissue. The stem cell populations, morphological cell types, and lineage relationships of Hydra are well characterized, but the molecular definition of its cell states has remained elusive. Capturing the molecular diversity of Hydra cells and the transcriptional programs underlying homeostatic development would greatly advance the utility of this organism for ta...
Published on May 1, 2019in Nature Ecology and Evolution
Christine E. Schnitzler16
Estimated H-index: 16
(Whitney Laboratory for Marine Bioscience)
Three studies presenting genomes and transcriptomes from different life stages of nearly all major lineages of medusozoans present radically different gene expression profiles between life cycle stages and many medusa-specific genes.
Published on Dec 1, 2018
David J. Duffy8
Estimated H-index: 8
(Bangor University),
Christine E. Schnitzler16
Estimated H-index: 16
(UF: University of Florida)
+ 10 AuthorsBette Zirkelbach1
Estimated H-index: 1
(Marathon Oil)
Wildlife populations are under intense anthropogenic pressures, with the geographic range of many species shrinking, dramatic reductions in population numbers and undisturbed habitats, and biodiversity loss. It is postulated that we are in the midst of a sixth (Anthropocene) mass extinction event, the first to be induced by human activity. Further, threatening vulnerable species is the increased rate of emerging diseases, another consequence of anthropogenic activities. Innovative approaches are...
Published in bioRxiv
Steven M. Sanders4
Estimated H-index: 4
(University of Pittsburgh),
Zhiwei Ma1
Estimated H-index: 1
(University of Pittsburgh)
+ -3 AuthorsAndreas D. Baxevanis5
Estimated H-index: 5
(NIH: National Institutes of Health)
Background: Hydractinia symbiolongicarpus, a colonial cnidarian, is a tractable model system for many cnidarian-specific and general biological questions. Until recently, tests of gene function in Hydractinia have relied on laborious forward genetic approaches, randomly integrated transgenes, or transient knockdown of mRNAs. Results: Here, we report the use of CRISPR/Cas9 genome editing to generate targeted genomic insertions in H. symbiolonigcarpus. We used CRISPR/Cas9 to promote homologous rec...
Published on Dec 1, 2017in Evodevo2.12
Christophe Dupré6
Estimated H-index: 6
(Columbia University),
Juris A. Grasis12
Estimated H-index: 12
(SDSU: San Diego State University)
+ 2 AuthorsCelina E. Juliano13
Estimated H-index: 13
(UC Davis: University of California, Davis)
Hydroidfest 2016 took place on September 23–25 at the UC Davis Bodega Marine Laboratory in Bodega Bay, CA. The meeting brought together cnidarian researchers, with an emphasis on those studying hydrozoans, from North America and other parts of the world. The scientific topics discussed were diverse, including sessions focused on development, regeneration, aging, immunology, symbiosis, and neurobiology. Thanks to the application of modern biological technologies, hydrozoans and other cnidarians a...
Published on Dec 1, 2017in Coral Reefs3.63
Jérémy Berthelier1
Estimated H-index: 1
(OSU: Oregon State University),
Christine E. Schnitzler16
Estimated H-index: 16
(UF: University of Florida)
+ 3 AuthorsOlivier Detournay4
Estimated H-index: 4
(OSU: Oregon State University)
Dinoflagellate–cnidarian associations form both the trophic and structural foundation of coral-reef ecosystems. Previous studies have highlighted the role of host innate immunity in regulation of these partnerships. This study reveals the presence of a transforming growth factor beta (TGFβ) in the coral Fungia scutaria that clusters with TGFβ sensu stricto (ss) from other animals. In functional studies of F. scutaria larvae, we show that (1) TGFβ ss mRNA is expressed during early stages of devel...
Published on Dec 1, 2017in Oceanography3.91
Steven H. D. Haddock4
Estimated H-index: 4
(UCSC: University of California, Santa Cruz),
Lynne M. Christianson4
Estimated H-index: 4
(MBARI: Monterey Bay Aquarium Research Institute)
+ 21 AuthorsC. Anela Choy1
Estimated H-index: 1
(UCSD: University of California, San Diego)
Published on Nov 1, 2017in Molecular Reproduction and Development2.12
Phillip L. Davidson (UM: University of Miami), Bernard J. Koch3
Estimated H-index: 3
(NIH: National Institutes of Health)
+ 4 AuthorsWilliam E. Browne14
Estimated H-index: 14
(UM: University of Miami)
The maternal-zygotic transition (MZT) describes the developmental reprogramming of gene expression marked by the degradation of maternally supplied gene products and activation of the zygotic genome. While the timing and duration of the MZT vary among taxa, little is known about early stage transcriptional dynamics in the non-bilaterian phylum Ctenophora. We sought to better understand the extent of maternal mRNA loading and subsequent differential transcript abundance during the earliest stages...
Published on Aug 1, 2017in Developmental Biology2.94
James M. Gahan2
Estimated H-index: 2
(National University of Ireland, Galway),
Christine E. Schnitzler16
Estimated H-index: 16
(UF: University of Florida)
+ 8 AuthorsAndreas D. Baxevanis43
Estimated H-index: 43
(NIH: National Institutes of Health)
The function of Notch signaling was previously studied in two cnidarians, Hydra and Nematostella, representing the lineages Hydrozoa and Anthozoa, respectively. Using pharmacological inhibition in Hydra and a combination of pharmacological and genetic approaches in Nematostella, it was shown in both animals that Notch is required for tentacle morphogenesis and for late stages of stinging cell maturation. Surprisingly, a role for Notch in neural development, which is well documented in bilaterian...
Published on Feb 1, 2017in Cell Reports7.82
Hakima Flici3
Estimated H-index: 3
(National University of Ireland, Galway),
Christine E. Schnitzler16
Estimated H-index: 16
(UF: University of Florida)
+ 6 AuthorsUri Frank20
Estimated H-index: 20
(National University of Ireland, Galway)
Summary SoxB transcription factors and histone deacetylases (HDACs) are each major players in the regulation of neurogenesis, but a functional link between them has not been previously demonstrated. Here, we show that SoxB2 and Hdac2 act together to regulate neurogenesis in the cnidarian Hydractinia echinata during tissue homeostasis and head regeneration. We find that misexpression of SoxB genes modifies the number of neural cells in all life stages and interferes with head regeneration. Hdac2 ...
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