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Shahnaz Perveen
University of Karachi
Organic chemistryChemistryIn vitroBiochemistryStereochemistry
243Publications
28H-index
2,804Citations
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Publications 236
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#1Shahbaz Shamim (KU: University of Karachi)H-Index: 3
#2Khalid Mohammed Khan (KU: University of Karachi)H-Index: 51
view all 11 authors...
Abstract (E)-3-(2-Benzylidenehydrazinyl)-5,6-diphenyl-1,2,4-triazines analogs 1-27 were synthesized by multi-step reaction scheme and subjected to in vitro inhibitory screening against α-amylase and α-glucosidase enzymes. Out of these twenty-seven synthetic analogs, ten compounds 14-17, 19, and 21-25 are structurally new. All compounds exhibited good to moderate inhibitory potential in terms of IC50 values ranging (IC50 =13.02 ± 0.04 - 46.90 ± 0.05 µM) and (IC50 =13.09 ± 0.08 - 46.44 ± 0.24 µM) ...
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#1Muhammad Shaiq Ali (KU: University of Karachi)H-Index: 24
#1Muhammad Ali (KU: University of Karachi)H-Index: 16
Last. Mohammad Ali Faramarzi (Tehran University of Medical Sciences)H-Index: 38
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Abstract Inhibition of α-glucosidase enzyme is of prime importance for the treatment of diabetes mellitus (DM). Apart of many organic scaffolds, pyridine based compounds have previously been reported for wide range of bioactivities. The current study reports a series of pyridine based synthetic analogues for their α-glucosidase inhibitory potential assessed by in vitro, kinetics and in silico studies. For this purpose, 2-amino-4-aryl-6-(phenylthio)pyridine-3,5-dicarbonitriles 1-28 were synthesiz...
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#1Emmanuel Oloruntoba Yeye (UI: University of Ibadan)H-Index: 1
#2Kanwal (KU: University of Karachi)H-Index: 7
Last. Shehryar Hameed (KU: University of Karachi)H-Index: 3
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Abstract Thirty-three 4-amino-1,2,4-triazole derivatives 1-33 were synthesized by reacting 4-amino-1,2,4-triazole with a variety of benzaldehydes. The synthetic molecules were characterized via 1H-NMR and EI-MS spectroscopic techniques and evaluated for their anti-hyperglycemic potential. Compounds 1-33 exhibited good to moderate in vitro α-amylase and α-glucosidase inhibitory activities in the range of IC50 values 2.01 ± 0.03 - 6.44 ± 0.16 and 2.09 ± 0.08 - 6.54 ± 0.10 µM as compared to the sta...
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#1Rafaila Rafique (KU: University of Karachi)H-Index: 3
#2Arshia (KU: University of Karachi)H-Index: 5
Last. Shahnaz PerveenH-Index: 28
view all 8 authors...
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#1Sarosh Iqbal (KU: University of Karachi)H-Index: 4
#2Ajmal Khan (KU: University of Karachi)H-Index: 22
Last. M. Iqbal Choudhary (KU: University of Karachi)H-Index: 44
view all 7 authors...
BACKGROUND: Peptic ulcer and urolithiasis are largely due to infection caused by urease producing bacteria. Therefore, discovery of urease inhibitors is an important area of medicinal chemistry research. OBJECTIVE: The main goal of the work was to identify novel urease inhibitors with no cytotoxicity. METHOD: During the current study, a series of β-ketosulfones 1-26 was synthesized in two steps and evaluated for their in vitro urease inhibition potential. RESULTS: Out of twenty-six compounds, se...
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#1Faiza Seraj (KU: University of Karachi)H-Index: 1
#2KanwalH-Index: 1
Last. Uzma Salar (KU: University of Karachi)H-Index: 15
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Novel ibuprofen derivatives 1–19 including ibuprofen hydrazide 1, and substituted thiourea derivatives 2–19 were synthesized and characterized by EI-MS, FAB-MS, HREI-MS, HRFAB-MS, 1H-, and 13C-NMR spectroscopic techniques. The synthetic molecules 1–19 were examined for their in vitro urease inhibition and were found to display a diversified degree of inhibitory potential in the range of IC50 = 2.96–178 μM as compared to the standard thiourea (IC50 = 21.32 ± 0.22 μM). Out of nineteen, thirteen de...
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#1Rafaila Rafique (KU: University of Karachi)H-Index: 3
#2Khalid Mohammed Khan (KU: University of Karachi)H-Index: 51
Last. Shahnaz PerveenH-Index: 28
view all 11 authors...
Abstract Over-expression of α-amylase enzyme causes hyperglycemia which lead to many physiological complications including oxidative stress, one of the most commonly associated problem with diabetes mellitus. Marketed α-amylase inhibitors such as acarbose, voglibose, and miglitol used to treat type-II diabetes mellitus, but also linked to several harmful effects. Therefore, it is essential to explore new and nontoxic antidiabetic agents with additional antioxidant properties. In this connection,...
5 CitationsSource
#1Sana Wahid (Federal Urdu University)H-Index: 1
#2Sajid Jahangir (Federal Urdu University)H-Index: 5
Last. Shahnaz PerveenH-Index: 28
view all 13 authors...
Abstract Current research deals with the biology-oriented drug synthesis (BIODS) of twenty-three new thiourea analogs of pharmacologically important drug atenolol which is a well-known medicine to treat hypertension as well as cardiovascular diseases (CVDs). Structural characterization of all compounds was done by various spectroscopic techniques. Compounds 1-23 were subjected for urease inhibitory activity in vitro. Screening results revealed that whole library was found to be active having IC5...
1 CitationsSource
#1Rafaila Rafique (KU: University of Karachi)H-Index: 3
#2Syed Muhammad Saad (KU: University of Karachi)H-Index: 11
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Abstract A convenient and facile CuCl2·2H2O catalyzed one-pot synthetic strategy was designed for the conversion of readily available dimedone into highly functionalized N-arylhydrazinecarbothioamide based indazole derivatives. The product yields were found to be moderate to good without purification requirements. Structural features of the synthetic compounds were confirmed by various spectroscopic techniques such as 1H NMR, 13C NMR, EI-MS, FAB-MS, HREI-MS, and HRFAB-MS. The reaction intermedia...
1 CitationsSource
#1Zahid Hussain (AWKUM: Abdul Wali Khan University Mardan)H-Index: 10
#2Nadia Bashir (HU: Hazara University)H-Index: 2
Last. Shahnaz PerveenH-Index: 28
view all 6 authors...
: A microwave-assisted diazotization reaction of ciprofloxacin was used for the analysis of ciprofloxacin in pharmaceutical samples. The ciprofloxacin was diazotized with phenol using acidified sodium nitrite in a domestic microwave oven. Faster microwave heating and microwave effects were found to be very effective for the process of diazotization. The microwave-assisted reaction was initiated in an acidic media and the colored product was stabilized in a slightly basic medium using a NaOH solu...
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