Match!
Thomas Frischer
Boston Children's Hospital
ImmunologyAllergyAsthmaAtopyMedicine
125Publications
35H-index
4,966Citations
What is this?
Publications 147
Newest
#1Shona S. Fielding (Aberd.: University of Aberdeen)
#2Mariëlle W. Pijnenburg (Boston Children's Hospital)H-Index: 18
Last. Stanley J. Szefler (University of Colorado Denver)H-Index: 87
view all 14 authors...
Introduction Fractional exhaled nitric oxide (FENO), a biomarker of eosinophilic airway inflammation, may be useful to guide asthma treatment. FENO guided treatment may be more effective in certain subgroups for improving asthma outcomes compared to standard treatment. Methods An individual patient data analysis was performed using data from seven randomised clinical trials (RCT) which used FENO to guide asthma treatment. The incidence of an asthma exacerbation and loss of control, and the time ...
Source
#1Shona Fielding (Aberd.: University of Aberdeen)H-Index: 19
#2Mariëlle W. Pijnenburg (Boston Children's Hospital)H-Index: 18
Last. Steve Turner (Aberd.: University of Aberdeen)H-Index: 22
view all 14 authors...
INTRODUCTION: Fractional exhaled nitric oxide (FE NO) may be a useful objective measurement to guide asthma treatment. What remains uncertain is what change in FE NO is clinically significant. METHODS: An individual patient data analysis was performed using data from seven randomized clinical trials which used FE NO to guide asthma treatment. The absolute and percentage intra-subject change in FE NO measurements over "stable" and also "unstable" 3-month periods were described. RESULTS: Data were...
Source
#1Shona FieldingH-Index: 19
Last. Steve TurnerH-Index: 22
view all 14 authors...
To the Editor: We thank Drs Yawn and Kaplan for their interest and comments on our article in which we describe a secondary analysis of data from seven published trials where fractional exhaled nitric oxide (Feno) was used to guide asthma treatment in children.1 We believe that our results offer relevance to clinicians attempting to interpret repeated measurements of spirometry and Feno. To the best of our knowledge, our analysis is the first to: (1) compare the clinical outcomes following a cha...
Source
#1Nicole Prinz (University of Ulm)H-Index: 4
#2A. Zolin (University of Milan)H-Index: 11
view all 12 authors...
Source
#1Shona Fielding (Aberd.: University of Aberdeen)H-Index: 19
#2Mariëlle W. Pijnenburg (Boston Children's Hospital)H-Index: 18
Last. Steve Turner (Aberd.: University of Aberdeen)H-Index: 22
view all 14 authors...
Background Repeated measurements of spirometry and fractional exhaled nitric oxide (Feno) are recommended as part of the management of childhood asthma, but the evidence base for such recommendations is small. We tested the hypothesis that reducing spirometric indices or increasing Feno will predict poor future asthma outcomes. Methods A one-stage individual patient data meta-analysis used data from seven randomized controlled trials in which Feno was used to guide asthma treatment; spirometric ...
4 CitationsSource
#1Stephen TurnerH-Index: 29
#2Shona FieldingH-Index: 19
Last. Robin VaelH-Index: 1
view all 14 authors...
Source
#1Clemens MaedelH-Index: 1
#2Katharina KainzH-Index: 1
Last. Angela ZacharasiewiczH-Index: 9
view all 5 authors...
2 CitationsSource
#1Philip M. Farrell (UW: University of Wisconsin-Madison)H-Index: 67
#2Claude Férec (French Institute of Health and Medical Research)H-Index: 63
Last. E. Genin (French Institute of Health and Medical Research)H-Index: 51
view all 17 authors...
The high incidence of cystic fibrosis (CF) is due to the frequency of the c.1521_1523delCTT variant in the cystic fibrosis transmembrane conductance regulator (CFTR), but its age and origin are uncertain. This gap limits attempts to shed light on the presumed heterozygote selective advantage that accounts for the variant’s high prevalence among Caucasian Europeans and Europe-derived populations. In addition, explaining the nature of heterozygosity to screened individuals with one c.1521_1523delC...
2 CitationsSource
#1Shona FieldingH-Index: 19
Last. Steve TurnerH-Index: 22
view all 14 authors...
Source
#1Stephen Turner (Aberd.: University of Aberdeen)H-Index: 29
#2Shona Fielding (Aberd.: University of Aberdeen)H-Index: 19
Last. Robin VaelH-Index: 1
view all 14 authors...
Background: Meta-analysis shows FeNO guided treatment reduces the risk of asthma attacks compared to standard management. Here we test the hypothesis that there are sub groups of patients where FeNO guided treatment is associated with reduced risk for asthma attacks. Methods: Data from 7 clinical trials were pooled. Baseline characteristics included age, sex, ethnicity (white versus other), dose of inhaled corticosteroid (ICS), receipt of long acting beta agonist, receipt of leukotriene receptor...
Source
12345678910