Benjamin Harich
Radboud University Nijmegen
Publications 7
#1Benjamin Harich (Radboud University Nijmegen)H-Index: 4
#2Marieke Klein (Radboud University Nijmegen)H-Index: 1
Last.Barbara Franke (Radboud University Nijmegen)H-Index: 76
view all 8 authors...
#1Benjamin Harich (Radboud University Nijmegen)H-Index: 4
#2Monique van der Voet (Radboud University Nijmegen)H-Index: 12
Last.Barbara Franke (Radboud University Nijmegen)H-Index: 76
view all 7 authors...
Aim: Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable psychiatric disorder. The objective of this study was to define ADHD-associated candidate genes, and their associated molecular modules and biological themes, based on the analysis of rare genetic variants. Methods: We combined data from 11 published copy number variation (CNV) studies in 6176 individuals with ADHD and 25026 controls and prioritized genes by applying an integrative strategy based on criteria including rec...
#1Marieke KleinH-Index: 10
#2Benjamin HarichH-Index: 4
Last.Barbara FrankeH-Index: 76
view all 8 authors...
#1Marieke Klein (Radboud University Nijmegen)H-Index: 10
#2Marten Onnink (Radboud University Nijmegen)H-Index: 8
Last.Barbara Franke (Radboud University Nijmegen)H-Index: 76
view all 10 authors...
Attention-deficit/hyperactivity disorder (ADHD) is a common and often persistent neurodevelopmental disorder. Beyond gene-finding, neurobiological parameters, such as brain structure, connectivity, and function, have been used to link genetic variation to ADHD symptomatology. We performed a systematic review of brain imaging genetics studies involving 62 ADHD candidate genes in childhood and adult ADHD cohorts. Fifty-one eligible research articles described studies of 13 ADHD candidate genes. Al...
23 CitationsSource
#1Holly A. F. Stessman (Creighton University)H-Index: 19
#2Bo Xiong (Creighton University)H-Index: 17
Last.Evan E. Eichler (UW: University of Washington)H-Index: 141
view all 53 authors...
Evan Eichler and colleagues use single-molecule molecular-inversion probes to sequence the coding and splicing regions of 208 candidate genes in more than 11,730 individuals with neurodevelopmental disorders. They report 91 genes with an excess of de novo or private disruptive mutations, identify 25 genes showing a bias for autism versus intellectual disability, and highlight a network associated with high-functioning autism.
135 CitationsSource
#1M van der Voet (Radboud University Nijmegen)H-Index: 1
#2Benjamin Harich (Radboud University Nijmegen)H-Index: 4
Last.Annette Schenck (Radboud University Nijmegen)H-Index: 31
view all 4 authors...
Attention-deficit/hyperactivity disorder (ADHD) is a common, highly heritable neuropsychiatric disorder with hyperactivity as one of the hallmarks. Aberrant dopamine signaling is thought to be a major theme in ADHD, but how this relates to the vast majority of ADHD candidate genes is illusive. Here we report a Drosophila dopamine-related locomotor endophenotype that is shared by pan-neuronal knockdown of orthologs of the ADHD-associated genes Dopamine transporter (DAT1) and Latrophilin (LPHN3), ...
39 CitationsSource
Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neuropsychiatric disorder with a complex genetic background. The G protein-coupled receptor kinase interacting ArfGAP 1 (GIT1) gene was previously associated with ADHD. We aimed at replicating the association of GIT1 with ADHD and investigated its role in cognitive and brain phenotypes. Gene-wide and single variant association analyses for GIT1 were performed for three cohorts: (1) the ADHD meta-analysis data set of the Psychiatric Geno...
11 CitationsSource