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Verônica Coelho
University of São Paulo
45Publications
12H-index
647Citations
Publications 47
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#1Priscila Carmona (USP: University of São Paulo)
#2Yordanka Medina-Armenteros (USP: University of São Paulo)H-Index: 1
Last.Verônica Coelho (USP: University of São Paulo)H-Index: 12
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#1Amanda Cabral (USP: University of São Paulo)
#2Darlan da Silva Cândido (USP: University of São Paulo)H-Index: 4
Last.Verônica Coelho (USP: University of São Paulo)H-Index: 12
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Abstract Background Operational tolerance (OT) is a state of graft functional stability that occurs after at least one year of immunosuppressant withdrawal. MicroRNAs (microRNA) are small noncoding RNAs that downregulate messenger RNA/protein expression of innumerous molecules and are critical for homeostasis. We investigated whether OT in kidney transplantation displays a differential microRNA profile, which would suggest that microRNAs participate in Operational Tolerance mechanisms, and may r...
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#1Jéssica Barletto de Sousa Barros (Pontifícia Universidade Católica de Goiás)H-Index: 1
#2Paulo Silva (UFG: Universidade Federal de Goiás)H-Index: 1
Last.Irmtraut Araci Hoffmann Pfrimer (Pontifícia Universidade Católica de Goiás)H-Index: 3
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An early immune response to Zika virus (ZIKV) infection may determine its clinical manifestation and outcome, including neurological effects. However, low-grade and transient viremia limits the prompt diagnosis of acute ZIKV infection. We have investigated the plasma cytokine, chemokine, and growth factor profiles of 36 individuals from an endemic area displaying different symptoms such as exanthema, headache, myalgia, arthralgia, fever, hyperemia, swelling, itching, and nausea during early-phas...
2 CitationsSource
#1Paschoalina Romano (USP: University of São Paulo)H-Index: 7
#2Maria da Luz Fernandes (USP: University of São Paulo)H-Index: 1
Last.Nelson Zocoler Galante (USP: University of São Paulo)H-Index: 1
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Abstract Monitoring tacrolimus (Tac) exposure in cell matrices enriched with lymphocytes can improve Tac therapeutic drug monitoring (TDM) in solid organ transplant recipients. An UPLC–MS/MS based assay for Tac quantification in peripheral blood T CD4+ and B CD19+ lymphocytes was developed. Peripheral blood mononuclear cells (PBMC) were obtained by density gradient centrifugation and highly purified (purity >90%) T CD4+ and B CD19+ cell suspensions were acquired by magnetic negative selection fr...
1 CitationsSource
Purpose of reviewTo discuss the B-cell diverse functions in organ transplantation, highlighting the emerging debate on the role of regulatory B cells (Bregs). We underscore the need to re-examine and integrate data on B-cell functional activities, aiming to discriminate their regulatory (REG) and in
17 CitationsSource
#1Verônica Coelho (USP: University of São Paulo)H-Index: 12
#2Ana Maria Caetano Faria (UFMG: Universidade Federal de Minas Gerais)H-Index: 27
Heat shock proteins 60 (HSP60) is one of the most well studied member of the HSP family. Although found to be a target self antigen in pathological autoimmunity and HSP60-reactive T and B cells are part of immune responses in several infectious diseases, there is consistent experimental evidence that HSP60 displays dominant immunoregulatory properties. There are a series of reports on animal models showing that the administration of HSP60 can modulate inflammatory diseases. However, HSP60 has bo...
13 CitationsSource
#1Verônica Coelho (USP: University of São Paulo)H-Index: 12
#2Rafael Ioschpe (USP: University of São Paulo)
Last.Anna Carla GoldbergH-Index: 29
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RESUMO Objetivo: Avaliar o impacto de longo prazo (com seguimento minimo de 2 anos) de polimorfismos em genes de citocinas em pares doador:receptor sobre os resultados do transplante. Metodos: Comparamos os polimorfismos geneticos das citocinas e os principais fatores de risco para o desenvolvimento de rejeicao cronica em grupos pareados de pacientes transplantados renais com e sem nefropatia cronica do aloenxerto [CAN]. Resultados: A analise multivariada indicou que a presenca do genotipo TT (c...
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#1Verônica Coelho (USP: University of São Paulo)H-Index: 12
#2Rafael Ioschpe (USP: University of São Paulo)
Last.Anna Carla GoldbergH-Index: 29
view all 9 authors...
Objective: To assess the long-term impact (minimum of 3 years follow-up) of polymorphisms in cytokine genes in donor:recipient pairs on the results of the transplant. Methods: We compared genetic cytokine polymorphisms and the primary factors of risk for the development of chronic rejection in paired groups of renal transplant patients with and without chronic allograft nephropathy [CAN]. Results: Multivariate analysis indicated that the presence of the high-production TT genotype (codon 10) of ...
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Background: Mast cells are multifunctional cells containing various mediators, such as cytokines, proteases, and histamine. Recent studies have shown that mast cells can affect disease progression after acute myocardial infarction. Here, we evaluated the effects of mast cell granules (MCGs) at different concentrations on various cell types, such as rat neonatal cardiomyocytes (rCMs), human endothelial progenitor cells (hEPCs), and human umbilical vein endothelial cells (hUVECs), and in a rat mod...
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