Ram Weiss
Hebrew University of Jerusalem
EndocrinologyInsulin resistanceObesityDiabetes mellitusMedicine
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Publications 117
#1Tair Ben-Porat (HUJI: Hebrew University of Jerusalem)H-Index: 5
#2Ram Elazary (HUJI: Hebrew University of Jerusalem)H-Index: 15
Last. Amihai Rottenstreich (HUJI: Hebrew University of Jerusalem)H-Index: 7
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PURPOSE Nutritional deficiencies, particularly anemia, are commonly encountered following bariatric surgery. While anemia during pregnancy is associated with various adverse maternal and perinatal outcomes, the factors associated with its occurrence following bariatric surgery have not been established. We explored the factors associated with the development of anemia during pregnancy after laparoscopic sleeve gastrectomy (SG). MATERIALS AND METHODS We reviewed the records of women who underwent...
#1Kobi Gorin (HUJI: Hebrew University of Jerusalem)
#2Mordechai Golomb (HUJI: Hebrew University of Jerusalem)H-Index: 2
Last. Ronen Durst (HUJI: Hebrew University of Jerusalem)H-Index: 19
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: Herein, we report a phenotypic and genetic evaluation of a consanguineous family with Congenital generalized lipodystrophy (CGL). Lipodystrophies are acquired or inherited disorders characterized by loss of adipose tissue, with distribution that is either generalized or partial. CGL is characterized by nearly complete absence of adipose tissue from birth. Affected patients are predisposed to insulin resistance and its complications, including diabetes mellitus (DM), dyslipidemia, hepatic steat...
Abstract Background Nutritional deficiencies are a well-recognized long-term complication following bariatric surgery. The presence of preoperative deficiencies has been shown to be predictive of postoperative deficiencies. Objective The aim of the study was to investigate the prevalence of micronutrient deficiency in a large sample of patients with severe obesity preoperatively, and to determine whether such deficiencies may be related to patient's sex, body mass index, or ethnic subgroup. Desi...
#1Sonia Caprio (Yale University)H-Index: 65
#2Nicola Santoro (Yale University)H-Index: 31
Last. Ram Weiss (Boston Children's Hospital)H-Index: 34
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Childhood obesity is one of the most serious global public-health challenges of the twenty-first century. Over the past four decades, the number of children and adolescents with obesity has risen more than tenfold. Worldwide, an increasing number of youth are facing greater exposure to obesity throughout their lives, and this increase will contribute to the early development of type 2 diabetes, fatty liver and cardiovascular complications. Herein, we provide a brief overview of trends in the glo...
#1Alfonso Galderisi (Yale University)H-Index: 10
#2David Polidori (Janssen Pharmaceutica)H-Index: 26
Last. Sonia Caprio (Yale University)H-Index: 65
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We examined the relationship between insulin clearance, insulin sensitivity, and β-cell function and the longitudinal effect of insulin clearance on β-cell function in lean and obese insulin-sensitive and insulin-resistant adolescents. A hyperinsulinemic-euglycemic and a hyperglycemic clamp were performed in 110 youths to quantify hepatic and peripheral clearance, insulin sensitivity, and β-cell function (disposition index, DIh-clamp). Participants underwent an oral glucose tolerance test at bas...
#1Vardit Gepstein (Boston Children's Hospital)H-Index: 3
#2Ram Weiss (Boston Children's Hospital)H-Index: 34
Abstract Obesity in childhood is the main determinant of whole body reduced insulin sensitivity. This association has been demonstrated in multiple adult and pediatric cohorts. The mechanistic link explaining this association is the pattern of lipid partitioning in the face of excess calories and energy surplus. A tight relation exists between typical lipid deposition patterns, specifically within the skeletal muscle and liver, as well as he intra-abdominal compartment and whole body insulin sen...
1 CitationsSource
#1Alfonso GalderisiH-Index: 10
#2Domenico TricòH-Index: 9
Last. Ram WeissH-Index: 34
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Background: Hyperinsulinemia results from β-cell ompensatory adaptation to insulin resistance and reduced insulin clearance. We examined the relationship between hepatic/peripheral insulin clearance and β-cell function in lean and obese insulin sensitive (IS) and insulin resistant (IR) adolescents. Methods: A 2-step euglycemic hyperinsulinemic clamp and an hyperglycemic clamp were performed in 153 youths (73F, 14.4±3.3y) to evaluate hepatic (MCR1) and peripheral (MCR2) insulin clearance, β-cell ...
#1Rana Swed-Tobia (Boston Children's Hospital)H-Index: 1
#2Ahmad Haj (Boston Children's Hospital)H-Index: 1
Last. Yonatan Butbul Aviel (Boston Children's Hospital)H-Index: 5
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Abstract Background Some children with autism spectrum disorder (ASD) have highly specific food selectivity and therefore are prone to nutritional deficiencies of different kinds. Patients We document three children with ASD who presented with refusal to walk and gingivitis who underwent comprehensive evaluations before establishing the diagnosis of vitamin C deficiency (scurvy). The symptoms resolved after treatment with vitamin C. Conclusions Prevention of nutritional deficiencies in children ...
1 CitationsSource
#1Emilia Hagman (HUJI: Hebrew University of Jerusalem)H-Index: 7
#2Omri Besor (Boston Children's Hospital)H-Index: 1
Last. Ram Weiss (Boston Children's Hospital)H-Index: 34
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Aims In this study, we investigated whether adipose tissue insulin resistance (IR) is affected by the degree of obesity during the fasting and post-prandial state, independent of glucose tolerance among obese children and adolescents. We also tested whether systemic subclinical inflammation is associated with adipose tissue IR.
1 CitationsSource
#1Emilia Hagman (HUJI: Hebrew University of Jerusalem)H-Index: 7
#2Lior Hecht (Boston Children's Hospital)H-Index: 1
Last. Ram Weiss (HUJI: Hebrew University of Jerusalem)H-Index: 34
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Background/Objective: Lifestyle modification is the therapy of choice for childhood obesity, yet the response rate is variable and may be affected by genetic factors. We aimed to investigate predictors of poor response to lifestyle modification obesity treatment in children. Methods: A prospective cohort study of 434 youths (64.5% females) between 4 and 20 years of age undergoing a standard care of lifestyle modification obesity management for 35.9 ± 20.8 months at Yale Childhood Obesity Clinic,...