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Haralambos Gavras
Boston University
294Publications
48H-index
9,285Citations
Publications 294
Newest
#1Michael BursztynH-Index: 28
#2Margaret BresnahanH-Index: 18
Last.Haralambos GavrasH-Index: 48
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The purpose of this study was to examine pressor hormones and platelet o^-adrenergic receptors in elderly unmedicated free-living subjects. Eighty-seven subjects, 70±5 years old (mean±SD), hypertensive or nonnotensive (blood pressure < 160/90 mm Hg) were recruited for measurement of blood levels of norepinephrine, epinephrine, and vasopressin, as well as density and affinity of «2-adrenergic receptors from platelet membranes, assessed by maximal binding (B^J and dissociation constant (A^) of rau...
#1Kouremenos NH-Index: 1
#2ZacharopoulouH-Index: 1
Last.Haralambos GavrasH-Index: 48
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sity (USA), we studied the role of various genes and single nucleotide polymorphisms (SNPs) in the inheritance or the onset of HTN in African-American, Caucasian-American and Greek families. Methods: Among 128 Greek families with a history of HTN, we studied 1474 people. Of the total examined, 273 men and 286 women were hypertensive. Based on 410 DNA samples from the hypertensive subjects, different SNPs were examined. An overall meta-analysis of the results from the Greek families, as well as a...
#1Maria E. MarketouH-Index: 14
#2Ekaterina Kintsurashvili (BU: Boston University)H-Index: 12
Last.Haralambos Gavras (BU: Boston University)H-Index: 48
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Abstract Background Platelets play a vital role in hemostasis and thrombosis. Catecholamines have a profound effect on platelet aggregation and atherothrombosis but the exact mechanism involved is insufficiently understood. In this report, we demonstrate the existence and role of alpha2B-adrenergic receptors (α2B-ARs) in normal human platelets. Methods Sixteen healthy individuals were recruited as donors of normal blood from which platelets were isolated. The presence of α2B-ARs in platelets was...
Purpose: Platelets play a vital role in hemostasis and thrombosis. Catecholamines have a profound effect on platelet aggregation and atherothrombosis but the exact mechanism involved is insufficiently understood. In this report, we demonstrate the existence and role of alpha2B–adrenergic receptors (α2B–ARs) in platelets from patients with Coronary Artery Disease (CAD) compared to normal individuals. Methods: Sixteen healthy individuals and 7 patients with CAD who were under dual antiplatelet the...
#1Milka Koupenova (BU: Boston University)H-Index: 15
#2Hillary Johnston-Cox (BU: Boston University)H-Index: 12
Last.Katya Ravid (BU: Boston University)H-Index: 44
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Background—The cAMP-elevating A2b adenosine receptor (A2bAR) controls inflammation via its expression in bone marrow cells. Methods and Results—Atherosclerosis induced by a high-fat diet in apolipoprotein E–deficient mice was more pronounced in the absence of the A2bAR. Bone marrow transplantation experiments indicated that A2bAR bone marrow cell signals alone were not sufficient to elicit this effect. Intriguingly, liver expression of the A2bAR in wild-type mice was vastly augmented by a high-f...
#2Maria E. MarketouH-Index: 14
Last.Haralambos GavrasH-Index: 48
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Following the introduction of angiotensin-converting enzyme (ACE) inhibitors in the treatment of hypertension and ischemic heart disease, there has been increasing interest in the bradykinin-mediated aspects of ACE inhibition. Several preclinical and clinical studies have been conducted using genetically engineered animals or pharmacological agonists and antagonists of the two receptors of bradykinin, B 1 R and B 2 R. The results have mostly indicated that the B 1 R, whose expression is induced ...
Rationale: The vasoactive peptide angiotensin II (Ang II) is a potent cardiotoxic hormone whose actions have been well studied, yet questions remain pertaining to the downstream factors that mediate its effects in cardiomyocytes. Objective: The in vivo role of the myocyte enhancer factor (MEF)2A target gene Xirp2 in Ang II–mediated cardiac remodeling was investigated. Methods and Results: Here we demonstrate that the MEF2A target gene Xirp2 (also known as cardiomyopathy associated gene 3 [ CMYA3...
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