Arjen E. van’t Hof
University of Liverpool
Publications 14
Background: Recent advances in genomics have addressed the challenge that divergent haplotypes pose to the reconstruction of haploid genomes. However for many organisms, the sequencing of either field-caught individuals or a pool of heterogeneous individuals is still the only practical option. Here we present methodological approaches to achieve three outcomes from pooled long read sequencing: the generation of a contiguous haploid reference sequence, the sequences of heterozygous haplotypes; an...
#1Amy Eacock (University of Liverpool)H-Index: 1
#2Hannah M. Rowland (University of Cambridge)H-Index: 17
Last.Ilik J. Saccheri (University of Liverpool)H-Index: 27
view all 6 authors...
Light sensing by tissues distinct from the eye occurs in diverse animal groups, enabling circadian control and phototactic behaviour. Extraocular photoreceptors may also facilitate rapid colour change in cephalopods and lizards, but little is known about the sensory system that mediates slow colour change in arthropods. We previously reported that slow colour change in twig-mimicking caterpillars of the peppered moth (Biston betularia) is a response to achromatic and chromatic visual cues. Here ...
#1Arjen E. van’t Hof (University of Liverpool)H-Index: 7
#2Louise A. Reynolds (University of Liverpool)H-Index: 1
Last.Ilik J. Saccheri (University of Liverpool)H-Index: 27
view all 5 authors...
The rise of dark (melanic) forms of many species of moth in heavily coal-polluted areas of nineteenth- and twentieth-century Britain, and their post-1970s fall, point to a common selective pressure...
#1Joe Turner (University of Liverpool)H-Index: 2
#2Ritesh Krishna (University of Liverpool)H-Index: 9
Last.Alistair C. Darby (University of Liverpool)H-Index: 33
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Background Aedes aegypti is the principal vector of several important arboviruses. Among the methods of vector control to limit transmission of disease are genetic strategies that involve the release of sterile or genetically modified non-biting males, which has generated interest in manipulating mosquito sex ratios. Sex determination in Ae. aegypti is controlled by a non-recombining Y chromosome-like region called the M locus, yet characterisation of this locus has been thwarted by the repetiti...
1 CitationsSource
#1Joseph ChabiH-Index: 3
#2Arjen E. van’t Hof (LSTM: Liverpool School of Tropical Medicine)H-Index: 7
Last.Helen Pates JametH-Index: 5
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The Anopheles gambiae sensu lato species complex consists of a number of cryptic species with different habitats and behaviours. These morphologically indistinct species are identified by chromosome banding and molecular diagnostic techniques which are still under improvement even though the current SINE method for identification between An. coluzzii and An. gambiae works reliably. This study describes a refinement of the SINE method to increase sensitivity and high throughput method for the ide...
2 CitationsSource
#1L. Basten Snoek (WUR: Wageningen University and Research Centre)H-Index: 24
#2Mark G. Sterken (WUR: Wageningen University and Research Centre)H-Index: 12
Last.Jan E. Kammenga (WUR: Wageningen University and Research Centre)H-Index: 36
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Abstract Background Cryptic genetic variation (CGV) is the hidden genetic variation that can be unlocked by perturbing normal conditions. CGV can drive the emergence of novel complex phenotypes through changes in gene expression. Although our theoretical understanding of CGV has thoroughly increased over the past decade, insight into polymorphic gene expression regulation underlying CGV is scarce. Here we investigated the transcriptional architecture of CGV in response to rapid temperature chang...
57 CitationsSource
#1Reuben W. Nowell (Edin.: University of Edinburgh)H-Index: 7
#2Ben Elsworth (Edin.: University of Edinburgh)H-Index: 9
Last.Mark Blaxter (Edin.: University of Edinburgh)H-Index: 77
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The mycalesine butterfly Bicyclus anynana, the “Squinting bush brown,” is a model organism in the study of lepidopteran ecology, development, and evolution. Here, we present a draft genome sequence for B. anynana to serve as a genomics resource for current and future studies of this important model species. Seven libraries with insert sizes ranging from 350 bp to 20 kb were constructed using DNA from an inbred female and sequenced using both Illumina and PacBio technology; 128 Gb of raw Illumina...
18 CitationsSource
#2Pascal CampagneH-Index: 1
Last.Ilik J. SaccheriH-Index: 27
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The mutation responsible for the black carbonaria morph of the peppered moth is identified as a transposable element within the cortex gene.
128 CitationsSource
#1Owen Thompson (UW: University of Washington)H-Index: 7
#2L. Basten Snoek (WUR: Wageningen University and Research Centre)H-Index: 24
Last.Robert H. Waterston (UW: University of Washington)H-Index: 80
view all 20 authors...
The Hawaiian strain (CB4856) of Caenorhabditis elegans is one of the most divergent from the canonical laboratory strain N2 and has been widely used in developmental, population and evolutionary studies. To enhance the utility of the strain, we have generated a draft sequence of the CB4856 genome, exploiting a variety of resources and strategies. The CB4856 genome when compared against the N2 reference has 327,050 single nucleotide variants (SNVs) and 79,529 insertion-deletion events (indels) th...
58 CitationsSource
#1Arjen E. van’t Hof (University of Liverpool)H-Index: 7
#2Nicola Edmonds (University of Liverpool)H-Index: 3
Last.Ilik J. Saccheri (University of Liverpool)H-Index: 27
view all 5 authors...
The rapid spread of a novel black form (known as carbonaria) of the peppered moth Biston betularia in 19th-century Britain is a textbook example of how an altered environment may produce morphological adaptation through genetic change. However, the underlying genetic basis of the difference between the wild-type (light-colored) and carbonaria forms has remained unknown. We have genetically mapped the carbonaria morph to a 200-kilobase region orthologous to a segment of silkworm chromosome 17 and...
102 CitationsSource