John F. Cryan
University College Cork
EndocrinologyPsychologyGut floraMedicineBiology
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Publications 713
Abstract The ghrelinergic system has been steadily investigated as a therapeutic target in the treatment of metabolic disorders and modulation of appetite. While endogenous ghrelin activates the full complement of the growth hormone secretagogue receptor (GHSR-1a) pathways, synthetic GHSR-1a ligands display biased signalling and functional selectivity, which have a significant impact on the intended and indeed, unintended, therapeutic effects. The widespread expression of the GHSR-1a receptor in...
#1Peijun Tian (Jiangnan University)H-Index: 1
#2Kenneth J. O'Riordan (UCC: University College Cork)H-Index: 2
Last. Wei Chen
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Abstract Background Accumulating evidence points to an association between gut microbial abnormalities and depression disorder. The microbiota-gut-brain axis is an emerging target for treating depression using nutritional strategies, considering the numerous limitations of current pharmacological approaches. Here we studied the effect and probable mechanisms of psychobiotic treatment on depression. Methods Chronically stressed C57BL/6J male mice were administered viable Bifidobacterium breve CCF...
#1Joy Y. BaltaH-Index: 3
#2Giorgio BlomH-Index: 1
Last. John CassellaH-Index: 15
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#1Jacinta Walsh (UCC: University College Cork)H-Index: 1
#2Loreto Olavarria-Ramirez (UCC: University College Cork)H-Index: 2
Last. Gerard Clarke (UCC: University College Cork)H-Index: 47
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The gastrointestinal tract houses a reservoir of bacterial-derived enzymes which can directly catalyze the metabolism of drugs, dietary elements, and endogenous molecules. Both host and environmental factors may influence this enzymatic activity, with the potential to dictate the availability of the biologically-active form of endogenous molecules in the gut and influence inter-individual variation in drug metabolism. We aimed to investigate the influence of the microbiota, and the modulation of...
#1Milou Straathof (UU: Utrecht University)H-Index: 2
#2Erwin L. A. Blezer (UU: Utrecht University)H-Index: 27
Last. Maarten Mennes (Radboud University Nijmegen)H-Index: 35
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Abstract Obsessive-compulsive disorder (OCD) is increasingly considered to be a neurodevelopmental disorder. However, despite insights in neural substrates of OCD in adults, less is known about mechanisms underlying compulsivity during brain development in children and adolescents. Therefore, we developed an adolescent rat model of compulsive checking behavior and investigated developmental changes in structural and functional measures in the frontostriatal circuitry. Five-weeks old Sprague Dawl...
#1Emily M. Teichman (UCC: University College Cork)H-Index: 1
#2Kenneth J. O'Riordan (UCC: University College Cork)H-Index: 2
Last. John F. Cryan (UCC: University College Cork)H-Index: 91
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The microbiota-gut-brain axis encompasses a bidirectional mode of communication between the microorganisms residing in our gut, and our brain function and behavior. The composition of the gut microbiota is subject to diurnal variation and is entrained by host circadian rhythms. In turn, a diverse microbiota is essential for optimal regulation of host circadian pathways. Disruption of the cyclical nature of this microbe-host interaction profoundly influences disease pathology and severity. This r...
#1Muhammad Asim Javaid (UCC: University College Cork)H-Index: 1
#2Harriët Schellekens (UCC: University College Cork)H-Index: 16
Last. André Toulouse (UCC: University College Cork)H-Index: 17
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#1Paul M. Ryan (UCC: University College Cork)H-Index: 7
#2Elaine Patterson (UCC: University College Cork)H-Index: 8
Last. R. Paul Ross (UCC: University College Cork)H-Index: 73
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Abstract Objectives Recent evidence indicates that gut microbiota is altered considerably by a variety of commonly prescribed medications. This study assessed the impact of 2 antidiabetic therapeutics on gut microbiota and markers of cardiometabolic disease in metabolically dysfunctional mice. Methods C57BL/6 mice were fed a high-fat diet for 24 weeks while receiving 1 of 2 antidiabetic therapeutics—metformin or dipeptidase peptidyl-4 (DPP-4) inhibitor, PKF-275-055—for the final 12 weeks. Mice w...
#1Isabella M. Scheepers (NWU: North-West University)H-Index: 1
#2John F. Cryan (UCC: University College Cork)H-Index: 91
Last. De Wet Wolmarans (NWU: North-West University)H-Index: 4
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1 CitationsSource
#1Caitlin S. M. Cowan (UCC: University College Cork)H-Index: 7
#2Timothy G. Dinan (UCC: University College Cork)H-Index: 88
Last. John F. Cryan (UCC: University College Cork)H-Index: 91
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The gut microbiota is a vast, complex, and fascinating ecosystem of microorganisms that resides in the human gastrointestinal tract. As an integral part of the microbiota-gut-brain axis, it is now being recognized that the microbiota is a modulator of brain and behavior, across species. Intriguingly, periods of change in the microbiota coincide with the development of other body systems and particularly the brain. We hypothesize that these times of parallel development are biologically relevant,...
2 CitationsSource