Sarah Takushi
Emory University
T cellSIGLECExtracellularIntracellularViral envelope
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Publications 2
#1Sarah Takushi (Emory University)H-Index: 1
#2Na Yoon Paik (Emory University)H-Index: 2
Last. Shanmuganathan Chandrakasan (Emory University)H-Index: 11
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Familial hemophagocytic lymphohistiocytosis type III (FHL3) is a rare disease caused by mutations to the UNC13D gene and the subsequent absence or decreased activity of the Munc13-4 protein. Munc13-4 is essential for the exocytosis of perforin and granzyme containing granules from cytotoxic cells. Without it, these cells are able to recognize an immunological insult but are unable to execute their cytotoxic functions. The result is a hyper-inflammatory state that, if left untreated, is fatal. Cu...
#1Jason Hammonds (Cincinnati Children's Hospital Medical Center)H-Index: 15
#2Neal Beeman (Emory University)H-Index: 8
Last. Paul Spearman (Cincinnati Children's Hospital Medical Center)H-Index: 38
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HIV-1 particles assemble and bud from the plasma membrane of infected T lymphocytes. Infected macrophages, in contrast, accumulate particles within an apparent intracellular compartment known as the virus-containing compartment or VCC. Many aspects of the formation and function of the VCC remain unclear. Here we demonstrate that VCC formation does not actually require infection of the macrophage, but can be reproduced through the exogenous addition of non-infectious virus-like particles or infec...
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