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Marc Y. Donath
University of Basel
186Publications
57H-index
14.8kCitations
Publications 186
Newest
Marc Y. Donath57
Estimated H-index: 57
(University of Basel)
Findeisen et al. have engineered IC7Fc, a cytokine for the treatment of type 2 diabetes, that selectively activates beneficial metabolic pathways systemically and in metabolic tissues without promoting an inflammatory response.
Published on Sep 12, 2019
Beckey Trinh , Matthias Hepprich1
Estimated H-index: 1
+ 11 AuthorsMartin Reincke54
Estimated H-index: 54
Published on Sep 9, 2019in Nature Reviews Immunology44.02
Marc Y. Donath57
Estimated H-index: 57
(University of Basel),
Charles A. Dinarello173
Estimated H-index: 173
(CU: University of Colorado Boulder),
Thomas Mandrup-Poulsen64
Estimated H-index: 64
(UCPH: University of Copenhagen)
Type 1 and type 2 diabetes are characterized by chronic inflammation; both diseases involve pancreatic islet inflammation, while systemic low-grade inflammation is a feature of obesity and type 2 diabetes. Long-term activation of the innate immune system impairs insulin secretion and action, and inflammation also contributes to macrovascular and microvascular complications of diabetes. However, despite strong preclinical evidence and proof-of-principle clinical trials demonstrating that targetin...
Published on Apr 25, 2019in Endocrine Reviews15.17
Marc Y. Donath57
Estimated H-index: 57
(University of Basel),
Daniel T. Meier2
Estimated H-index: 2
(University of Basel),
Marianne Böni-Schnetzler21
Estimated H-index: 21
(University of Basel)
Published on May 31, 2019in PLOS ONE2.78
Milica Popovic1
Estimated H-index: 1
(University of Basel),
Katharina Timper14
Estimated H-index: 14
(University of Basel)
+ 4 AuthorsMirjam Christ-Crain52
Estimated H-index: 52
(University of Basel)
Objective Studies have suggested that arginine vasopressin (AVP) and its surrogate marker copeptin increase during exercise, independently of serum sodium and/or osmolality. In extreme cases, this can lead to runners-induced hyponatremia. Interleukin-1 (IL-1) increases during exercise and induces AVP in animal models. We here therefore investigate whether copeptin (a surrogate marker for AVP) increases upon exercise in young and healthy males, and whether this increase is regulated by IL-1. Desi...
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