Thomas Thesen
New York University
Publications 82
#1Anli Liu (NYU: New York University)H-Index: 11
#2Daniel Freidman (NYU: New York University)H-Index: 33
Last.Patricia Dugan (NYU: New York University)H-Index: 7
view all 6 authors...
Abstract Background Early accounts of forced thought were reported at the onset of a focal seizure, and characterized as vague, repetitive, and involuntary intellectual auras distinct from perceptual or psychic hallucinations or illusions. Here, we examine the neural underpinnings involved in conceptual thought by presenting a series of 3 patients with epilepsy reporting intrusive thoughts during electrical stimulation of the left lateral prefrontal cortex (PFC) during invasive surgical evaluati...
#1Belen Lafon (CCNY: City College of New York)H-Index: 9
#2Simon Henin (NYU: New York University)H-Index: 8
Last.Anli Liu (NYU: New York University)H-Index: 11
view all 11 authors...
It has come to our attention that we did not specify whether the stimulation magnitudes we report in this Article are peak amplitudes or peak-to-peak. All references to intensity given in mA in the manuscript refer to peak-to-peak amplitudes, except in Fig. 2, where the model is calibrated to 1 mA peak amplitude, as stated. In the original version of the paper we incorrectly calibrated the computational models to 1 mA peak-to-peak, rather than 1 mA peak amplitude. This means that we divided by a...
#1Andre Altmann (UCL: University College London)H-Index: 21
#2Mina RytenH-Index: 39
Last.Sanjay M. Sisodiya (UCL Institute of Neurology)H-Index: 42
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The common human epilepsies are associated with distinct patterns of reduced cortical thickness, detectable on neuroimaging, with important clinical consequences. To explore underlying mechanisms, we layered MRI-based cortical structural maps from a large-scale epilepsy neuroimaging study onto highly spatially-resolved human brain gene expression data, identifying >2,500 genes overexpressed in regions of reduced cortical thickness, compared to relatively-protected regions. The resulting set of d...
#1Caspar M. Schwiedrzik (DPZ: German Primate Center)H-Index: 13
#2Sandrin S. Sudmann (DPZ: German Primate Center)
Last.Lucia Melloni (MPG: Max Planck Society)H-Index: 21
view all 10 authors...
Summary Our visual environment constantly changes, yet we experience the world as a stable, unified whole. How is this stability achieved? It has been proposed that the brain preserves an implicit perceptual memory in sensory cortices [1] which stabilizes perception towards previously experienced states [2,3]. The role of higher-order areas, especially prefrontal cortex (PFC), in perceptual memory is less explored. Because PFC exhibits long neural time constants, invariance properties, and large...
#1Erik Kaestner (UCSD: University of California, San Diego)H-Index: 5
#2Adam Milton Morgan (UCSD: University of California, San Diego)H-Index: 4
Last.Eric Halgren (UCSD: University of California, San Diego)H-Index: 70
view all 9 authors...
ABSTRACTIntracranial electrophysiology (iEEG) studies using cognitive tasks contribute to the understanding of the neural basis of language. However, though iEEG is recorded continuously during clinical treatment, due to patient considerations task time is limited. To increase the usefulness of iEEG recordings for language study we provided patients with a tablet pre-loaded with media filled with natural language, wirelessly synchronised to clinical iEEG. This iEEG data collected and time-locked...
#1Karen Blackmon (NYU: New York University)H-Index: 14
#2Thomas Thesen (NYU: New York University)H-Index: 26
Last.Orrin Devinsky (NYU: New York University)H-Index: 82
view all 8 authors...
5 CitationsSource
#1Ido Davidesco (NYU: New York University)H-Index: 8
#2Thomas Thesen (NYU: New York University)H-Index: 26
Last.Uri Hasson (Princeton University)H-Index: 48
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Human listeners understand spoken language across a variety of rates, but when speech is presented three times or more faster than its usual rate, it becomes unintelligible. How the brain achieves such tolerance and why speech becomes unintelligible above certain rates is still unclear. We addressed these questions using electrocorticography (ECoG) recordings in 7 epileptic patients (two female). Patients rated the intelligibility of sentences presented at the original rate (100%), speeded rates...
1 CitationsSource
#1Farras Abdelnour (Cornell University)H-Index: 4
#2Michael Dayan (Cornell University)H-Index: 9
Last.Ashish Raj (Cornell University)H-Index: 21
view all 5 authors...
Abstract How structural connectivity (SC) gives rise to functional connectivity (FC) is not fully understood. Here we mathematically derive a simple relationship between SC measured from diffusion tensor imaging, and FC from resting state fMRI. We establish that SC and FC are related via (structural) Laplacian spectra, whereby FC and SC share eigenvectors and their eigenvalues are exponentially related. This gives, for the first time, a simple and analytical relationship between the graph spectr...
11 CitationsSource
#1Sophie Green (NYU: New York University)H-Index: 2
#2Karen Blackmon (NYU: New York University)H-Index: 14
Last.Orrin Devinsky (NYU: New York University)H-Index: 82
view all 7 authors...
Gyrification of the cortical mantle is a dynamic process that increases with cortical surface area and decreases with age. Increased gyrification is associated with higher scores on cognitive tasks in adults; however, the degree to which this relationship is independent of cortical surface area remains undefined. This study investigates whether regional variation in gyrification is associated with domain-general and domain-specific cognition. Our hypothesis is that increased local gyrification c...
4 CitationsSource
#1Christopher D. Whelan (SC: University of Southern California)H-Index: 17
#2Andre Altmann (UCL: University College London)H-Index: 21
Last.Sanjay M. Sisodiya (UCL Institute of Neurology)H-Index: 15
view all 91 authors...
Progressive functional decline in the epilepsies is largely unexplained. We formed the ENIGMA-Epilepsy consortium to understand factors that influence brain measures in epilepsy, pooling data from 24 research centres in 14 countries across Europe, North and South America, Asia, and Australia. Structural brain measures were extracted from MRI brain scans across 2149 individuals with epilepsy, divided into four epilepsy subgroups including idiopathic generalized epilepsies (n =367), mesial tempora...
39 CitationsSource