Maggie L. Bobbin
Beckman Research Institute
AptamerRNA interferenceRNAi TherapeuticsBioinformaticsMedicine
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Publications 3
A resurgence in clinical trials using RNA interference (RNAi) occurred in 2012. Although there were initial difficulties in achieving efficacious results with RNAi without toxic side effects, advances in delivery and improved chemistry made this resurgence possible. More than 20 RNAi-based therapeutics are currently in clinical trials, and several of these are Phase III trials. Continued positive results from these trials have helped bolster further attempts to develop clinically relevant RNAi t...
138 CitationsSource
#1Maggie L. Bobbin (Beckman Research Institute)H-Index: 4
#2John C. Burnett (Beckman Research Institute)H-Index: 19
Last. John Rossi J (Beckman Research Institute)H-Index: 84
view all 3 authors...
HIV/AIDS is a chronic and debilitating disease that cannot be cured with current antiretroviral drugs. While combinatorial antiretroviral therapy (cART) can potently suppress HIV-1 replication and delay the onset of AIDS, viral mutagenesis often leads to viral escape from multiple drugs. In addition to the pharmacological agents that comprise cART drug cocktails, new biological therapeutics are reaching the clinic. These include gene-based therapies that utilize RNA interference (RNAi) to silenc...
34 CitationsSource
#1Jiehua Zhou (Beckman Research Institute)H-Index: 29
#2Maggie L. Bobbin (Beckman Research Institute)H-Index: 4
Last. John Rossi J (Beckman Research Institute)H-Index: 84
view all 4 authors...
Aptamers are single-stranded nucleic acids that specifically recognize and bind tightly to their cognate targets due to their stable three-dimensional structure. Nucleic acid aptamers have been developed for various applications, including diagnostics, molecular imaging, biomarker discovery, target validation, therapeutics, and drug delivery. Due to their high specificity and binding affinity, aptamers directly block or interrupt the functions of target proteins making them promising therapeutic...
72 CitationsSource