Joost H.A. Martens
Radboud University Nijmegen
Molecular biologyEpigeneticsGeneticsChromatinBiology
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Publications 98
#1Gaëlle Cordonnier (Paris V: Paris Descartes University)H-Index: 2
#2Amit Mandoli (Radboud University Nijmegen)H-Index: 10
Last. Jonathan BondH-Index: 9
view all 11 authors...
Summary Mutations and deletions of polycomb repressive complex (PRC) components are increasingly recognized to affect tumor biology in a range of cancers. However, little is known about how genetic alterations of PRC-interacting molecules such as the core binding factor (CBF) complex influence polycomb activity. We report that the acute myeloid leukemia (AML)-associated CBFβ-SMMHC fusion oncoprotein physically interacts with the PRC1 complex and that these factors co-localize across the AML geno...
#1Albertus T. J. Wierenga (UMCG: University Medical Center Groningen)H-Index: 17
#2Alan Cunningham (UMCG: University Medical Center Groningen)
Last. Jan Jacob Schuringa (UMCG: University Medical Center Groningen)H-Index: 35
view all 11 authors...
Hypoxia-inducible factors (HIF)1 and 2 are transcription factors that regulate the homeostatic response to low oxygen conditions. Since data related to the importance of HIF1 and 2 in hematopoietic stem and progenitors is conflicting, we investigated the chromatin binding profiles of HIF1 and HIF2 and linked that to transcriptional networks and the cellular metabolic state. Genome-wide ChIPseq and ChIP-PCR experiments were performed to identify HIF1 and HIF2 binding sites in human acute myeloid ...
#1Esther Tijchon (Radboud University Nijmegen)H-Index: 7
#2Guoqiang Yi (Radboud University Nijmegen)H-Index: 3
Last. Joost H.A. Martens (Radboud University Nijmegen)H-Index: 30
view all 11 authors...
Acute myeloid leukemia (AML) is characterized by recurrent mutations that affect normal hematopoiesis. The analysis of human AMLs has mostly been performed using end-point materials, such as cell lines and patient derived AMLs that also carry additional contributing mutations. The molecular effects of a single oncogenic hit, such as expression of the AML associated oncoprotein AML1-ETO on hematopoietic development and transformation into a (pre-) leukemic state still needs further investigation....
#1Katharina Mattes (UMCG: University Medical Center Groningen)H-Index: 1
#2Mylene Gerritsen (UMCG: University Medical Center Groningen)
Last. Edo Vellenga (UMCG: University Medical Center Groningen)H-Index: 74
view all 9 authors...
#1Gerbrig Berger (UMCG: University Medical Center Groningen)H-Index: 3
#2Mylene Gerritsen (UMCG: University Medical Center Groningen)
Last. Edo Vellenga (UMCG: University Medical Center Groningen)H-Index: 74
view all 16 authors...
Ring sideroblasts (RS) emerge as result of aberrant erythroid differentiation leading to excessive mitochondrial iron accumulation, a characteristic feature for myelodysplastic syndromes (MDS) with mutations in the spliceosome gene SF3B1. However, RS can also be observed in patients diagnosed with acute myeloid leukemia (AML). The objective of this study was to characterize RS in patients with AML. Clinically, RS-AML is enriched for ELN adverse risk (55%). In line with this finding, 35% of all c...
#1Luigi Grassi (University of Cambridge)H-Index: 43
#2Osagie G. Izuogu (EMBL-EBI: European Bioinformatics Institute)H-Index: 4
Last. Mattia Frontini (University of Cambridge)H-Index: 21
view all 27 authors...
Transcriptional profiling of hematopoietic cell subpopulations has helped characterize the developmental stages of the hematopoietic system and the molecular basis of malignant and non-malignant blood diseases for the past three decades. The introduction of high-throughput RNA sequencing has increased knowledge of the full repertoire of RNA molecules in hematopoietic cells of different types, without relying on prior gene annotation. Here, we introduce the analysis of the BLUEPRINT consortium ge...
2 CitationsSource
#1R. Ordoñez (CIMA: Chartered Institute of Management Accountants)H-Index: 1
#2Marta KulisH-Index: 18
Last. José I. Martín-SuberoH-Index: 81
view all 34 authors...
Multiple myeloma (MM) is a plasma cell neoplasm associated with a broad variety of genetic lesions. In spite of this genetic heterogeneity, MMs share a characteristic malignant phenotype whose underlying molecular basis remains poorly characterized. In the present study, we examined plasma cells from MM using a multi-epigenomics approach and demonstrated that when compared to normal B cells, malignant plasma cells showed an extensive activation of regulatory elements, in part affecting co-regula...
#1Irene Di Ceglie (Radboud University Nijmegen)H-Index: 5
#2A.B. Blom (Radboud University Nijmegen)H-Index: 31
Last. Martijn H. van den Bosch (Radboud University Nijmegen)H-Index: 9
view all 13 authors...
The alarmin S100A8/A9 is implicated in sterile inflammation-induced bone resorption and has been shown to increase the bone-resorptive capacity of mature osteoclasts. Here, we investigated the effe...
2 CitationsSource
#1Maria Azkanaz (UMCG: University Medical Center Groningen)H-Index: 1
#2Aida Rodríguez López (UMCG: University Medical Center Groningen)H-Index: 1
Last. Vincent van den Boom (UMCG: University Medical Center Groningen)H-Index: 8
view all 11 authors...
All cells in our bodies contain the same sequence of DNA, hence the same genes, in a compartment called the nucleus. Yet different sets of genes are switched on in different types of cells. Cells achieve this by a process called epigenetic regulation. Proteins known as epigenetic regulators modify DNA and its associated proteins in ways that can turn genes on or off. Different types of cells contain different epigenetic regulators, and so express different genes. The Polycomb group proteins (or ...
1 CitationsSource
#1S. Heshusius (EUR: Erasmus University Rotterdam)
#2Esther HeideveldH-Index: 3
Last. Emile van den AkkerH-Index: 14
view all 11 authors...
Transfusion of donor-derived red blood cells is the most common form of cellular therapy. Donor availability and the potential risk of alloimmunization and other transfusion-related complications may, however, limit the availability of transfusion units especially for chronically transfused patients. In-vitro cultured, customizable red blood cells would negate these concerns and introduce precision medicine. Large-scale, cost effective production depends on optimization of culture conditions. We...