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Charles Theillet
French Institute of Health and Medical Research
CancerCancer researchBreast cancerGeneticsBiology
166Publications
56H-index
10kCitations
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Publications 168
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#1Diala Kantar (French Institute of Health and Medical Research)
#2Emilie Bousquet Mur (French Institute of Health and Medical Research)
Last. Florence Boissière-Michot (ICM Partners)H-Index: 12
view all 17 authors...
Alterations to cell polarization or to intercellular junctions are often associated with epithelial cancer progression, including breast cancers (BCa). We show here that the loss of the junctional scaffold protein MAGI1 is associated with bad prognosis in luminal BCa, and promotes tumorigenesis. E-cadherin and the actin binding scaffold AMOTL2 accumulate in MAGI1 deficient cells which are subjected to increased stiffness. These alterations are associated with low YAP activity, the terminal Hippo...
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#1Madi Y. Cissé (University of Montpellier)H-Index: 2
#2Samuel Pyrdziak (University of Montpellier)H-Index: 1
Last. Giuseppe Arena (University of Montpellier)H-Index: 8
view all 19 authors...
Well-differentiated and dedifferentiated liposarcomas (LPSs) are characterized by a systematic amplification of the MDM2 oncogene, which encodes a key negative regulator of the p53 pathway. The molecular mechanisms underlying MDM2 overexpression while sparing wild-type p53 in LPS remain poorly understood. Here, we show that the p53-independent metabolic functions of chromatin-bound MDM2 are exacerbated in LPS and mediate an addiction to serine metabolism that sustains nucleotide synthesis and tu...
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#1William JacotH-Index: 25
#2Evelyne Lopez-Crapez (University of Montpellier)
Last. Raphaël SaffroyH-Index: 23
view all 12 authors...
The aberrant hypermethylation of BRCA1 promoter CpG islands induces the decreased expression of BRCA1 (Breast Cancer 1) protein. It can be detected in sporadic breast cancer without BRCA1 pathogenic variants, particularly in triple-negative breast cancers (TNBC). We investigated BRCA1 hypermethylation status (by methylation-specific polymerase chain reaction (MS-PCR) and MassARRAY® assays), and BRCA1 protein expression using immunohistochemistry (IHC), and their clinicopathological significance ...
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#1Laura Bourillon (University of Montpellier)H-Index: 1
#2Céline Bourgier (University of Montpellier)H-Index: 25
Last. Thierry Chardès (University of Montpellier)H-Index: 24
view all 17 authors...
1 CitationsSource
#1Claire Fonti (University of Montpellier)H-Index: 1
#2Anne Saumet (University of Montpellier)H-Index: 11
Last. Charles Theillet (University of Montpellier)H-Index: 56
view all 14 authors...
1 CitationsSource
#1Yahya Ashraf (French Institute of Health and Medical Research)H-Index: 2
#2Hanane Mansouri (French Institute of Health and Medical Research)
Last. Emmanuelle Liaudet-Coopman (French Institute of Health and Medical Research)H-Index: 12
view all 37 authors...
Background Triple-negative breast cancer (TNBC) treatment is currently restricted to chemotherapy. Hence, tumor-specific molecular targets and/or alternative therapeutic strategies for TNBC are urgently needed. Immunotherapy is emerging as an exciting treatment option for TNBC patients. The aspartic protease cathepsin D (cath-D), a marker of poor prognosis in breast cancer (BC), is overproduced and hypersecreted by human BC cells. This study explores whether cath-D is a tumor cell-associated ext...
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#1Elodie ChartronH-Index: 1
#2Charles Theillet (University of Montpellier)H-Index: 56
Last. William Jacot (University of Montpellier)H-Index: 25
view all 4 authors...
Abstract Mutation or epigenetic silencing of homologous recombination (HR) repair genes is characteristic of a growing proportion of triple-negative breast cancers (TNBCs) and high-grade serous ovarian carcinomas. Defects in HR lead to genome instability, allowing cells to acquire the multiple genetic alterations essential for cancer development. However, this deficiency can also be exploited by using DNA damaging agents or by targeting compensatory repair pathways. A noteworthy example is treat...
1 CitationsSource
#1Stan P. du manoir (University of Montpellier)
#2Claire Fonti (University of Montpellier)H-Index: 1
Last. Charles Theillet (University of Montpellier)H-Index: 56
view all 11 authors...
Gene expression differences, combined with distinct patterns of genomic rearrangements and epigenetic modifications constitute the bases of molecular classification of breast cancer. Molecular subtypes may originate from different cell lineages in the mammary gland, but also from the early activation of oncogenes that may drive the establishment of these molecular subtypes. However, in the natural history of human cancer, it is difficult to discriminate between these two factors : cell lineage a...
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#1Claire Fonti (University of Montpellier)H-Index: 1
#2Anne Saumet (French Institute of Health and Medical Research)H-Index: 11
Last. Charles Theillet (French Institute of Health and Medical Research)H-Index: 56
view all 14 authors...
Gene expression differences, combined with distinct patterns of genomic rearrangements and epigenetic modifications, have laid the bases of molecular classification of breast cancer. Different molecular subtypes are thought to originate from different cell lineages in the mammary gland, but the early activation of an oncogene could also play a role. It is, however, difficult to discriminate the respective inputs of oncogene activation or cell type of origin in the natural history of the tumor. I...
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#1Y Idoux-Gillet (University of Montpellier)H-Index: 1
#2M Nassour (University of Montpellier)H-Index: 1
Last. Pierre Savagner (University of Montpellier)H-Index: 27
view all 7 authors...
Mammary gland morphogenesis results from the coordination of proliferation, cohort migration, apoptosis and stem/progenitor cell dynamics. We showed earlier that the transcription repressor Slug is involved in these functions during mammary tubulogenesis. Slug is expressed by a subpopulation of basal epithelial cells, co-expressed with P-cadherin (Pcad). Slug-knockout mammary glands showed excessive branching, similarly to Pcad-knockout. Here, we found that Slug unexpectedly binds and activates ...
3 CitationsSource
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