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Dana M. Small
Yale University
EndocrinologyPsychologyNeuroscienceOrbitofrontal cortexTaste
125Publications
40H-index
8,670Citations
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Publications 125
Newest
#1Jennifer R. Sadler (UNC: University of North Carolina at Chapel Hill)H-Index: 1
#2Grace E. Shearrer (UNC: University of North Carolina at Chapel Hill)H-Index: 6
Last. Kyle S. Burger (UNC: University of North Carolina at Chapel Hill)H-Index: 19
view all 9 authors...
Abstract Reinforcement learning guides food decisions, yet how the brain learns from taste in humans is not fully understood. Existing research examines reinforcement learning from taste using passive condition paradigms, but response-dependent instrumental conditioning better reflects natural eating behavior. Here, we examined brain response during a taste-motivated reinforcement learning task and how measures of task-based network structure were related to behavioral outcomes. During a functio...
1 CitationsSource
#1Michael C. Farruggia (Yale University)H-Index: 2
#2Maria J. van Kooten (Yale University)H-Index: 1
Last. Dana M. SmallH-Index: 40
view all 7 authors...
Abstract The brain plays a central role in the pathophysiology of overweight and obesity. Connectome-based Predictive Modeling (CPM) is a newly developed, data-driven approach that exploits whole-brain functional connectivity to predict a behavior or trait that varies across individuals. We used CPM to determine whether brain “fingerprints” evoked during milkshake consumption could be isolated for common measures of adiposity in 67 adults with overweight and obesity. We found that CPM captures m...
1 CitationsSource
#1Robert Pellegrino (TUD: Dresden University of Technology)H-Index: 8
#2Michael C. Farruggia (Yale University)H-Index: 2
Last. Maria G. Veldhuizen (Mersin University)H-Index: 2
view all 4 authors...
Olfactory impairment after trauma is associated with changes in olfactory cortex, including decreased gray matter density and decreased response to odors. Much less is known about the role of other cortical areas in olfactory impairment. We used fMRI in a sample of 63 participants, consisting of 25 with post-traumatic functional anosmia, 16 with post-traumatic hyposmia, and 22 healthy controls with normosmia to investigate whole brain response to odors. Similar neural responses were observed acr...
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#1Stephanie Kullmann (University of Tübingen)H-Index: 27
#2André KleinriddersH-Index: 23
Last. Martin Heni (University of Tübingen)H-Index: 32
view all 7 authors...
Summary Insulin acts on the CNS to modulate behaviour and systemic metabolism. Disturbances in brain insulin action represent a possible link between metabolic and cognitive health. Current findings from human research suggest that boosting central insulin action in the brain modulates peripheral metabolism, enhancing whole-body insulin sensitivity and suppressing endogenous glucose production. Moreover, central insulin action curbs food intake by reducing the salience of highly palatable food c...
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#1Kathryn M. Wall (Yale University)
#2Michael C. Farruggia (Yale University)H-Index: 2
Last. Dana M. SmallH-Index: 40
view all 9 authors...
Prevailing models of obesity posit that hedonic signals override homeostatic mechanisms to promote overeating in today’s food environment. What researchers mean by “hedonic” varies considerably, but most frequently refers to an aggregate of appetitive events including incentive salience, motivation, reinforcement, and perceived pleasantness. Here we define hedonic as orosensory pleasure experienced during eating and set out to test whether there is a relationship between adiposity and the percei...
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Chronic pain is a highly prevalent disease with poorly understood pathophysiology. In particular, the brain mechanisms mediating the transition from acute to chronic pain remain largely unknown. Here, we identify a subcortical signature of back pain. Specifically, subacute back pain patients who are at risk for developing chronic pain exhibit a smaller nucleus accumbens volume, which persists in the chronic phase, compared to healthy controls. The smaller accumbens volume was also observed in a ...
1 CitationsSource
#1Maria G. Veldhuizen (Yale University)H-Index: 18
#2Michael C. Farruggia (Yale University)H-Index: 2
Last. Dana M. SmallH-Index: 40
view all 6 authors...
Peripheral sources of individual variation in taste intensity perception have been well-described. The existence of a central source has been proposed but remains unexplored. Here we used functional magnetic resonance imaging in healthy human participants (20 women, 8 men) to evaluate the hypothesis that the amygdala exerts an inhibitory influence that affects the "gain" of the gustatory system during tasting. Consistent with the existence of a central gain mechanism (CGM), we found that central...
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#1Chloé Berland (University of Paris)
#1Chloé Berland (University of Paris)H-Index: 2
Last. Claire Martin (University of Paris)H-Index: 1
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Summary Energy-dense food alters dopaminergic (DA) transmission in the mesocorticolimbic (MCL) system and can promote reward dysfunctions, compulsive feeding, and weight gain. Yet the mechanisms by which nutrients influence the MCL circuitry remain elusive. Here, we show that nutritional triglycerides (TGs), a conserved post-prandial metabolic signature among mammals, can be metabolized within the MCL system and modulate DA-associated behaviors by gating the activity of dopamine receptor subtype...
1 CitationsSource
#1Jelle R. Dalenberg (Yale University)H-Index: 8
#2Barkha P. Patel (Yale University)H-Index: 3
Last. Dana M. Small (University of Tübingen)H-Index: 40
view all 8 authors...
Summary There is a general consensus that overconsumption of sugar-sweetened beverages contributes to the prevalence of obesity and related comorbidities such as type 2 diabetes (T2D). Whether a similar relationship exists for no- or low-calorie “diet” drinks is a subject of intensive debate and controversy. Here, we demonstrate that consuming seven sucralose-sweetened beverages with, but not without, a carbohydrate over 10 days decreases insulin sensitivity in healthy human participants, an eff...
2 CitationsSource
#1Jelle R. DalenbergH-Index: 8
#2Barkha P. PatelH-Index: 10
Last. Dana M. SmallH-Index: 40
view all 8 authors...
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