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M. Kerry O'Banion
University of Rochester
EndocrinologyImmunologyMicrogliaBiologyNeuroinflammation
88Publications
37H-index
8,557Citations
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Publications 92
Newest
#1Elizabeth K. Belcher (URMC: University of Rochester Medical Center)
#2Tara B. Sweet (URMC: University of Rochester Medical Center)
Last. M. Kerry O'Banion (URMC: University of Rochester Medical Center)H-Index: 37
view all 10 authors...
Abstract Microglia, the resident immune cells of the central nervous system (CNS), play multiple roles in maintaining CNS homeostasis and mediating tissue repair, including proliferating in response to brain injury and disease. Cranial irradiation (CI), used for the treatment of brain tumors, has a long-lasting anti-proliferative effect on a number of cell types in the brain, including oligodendrocyte progenitor and neural progenitor cells; however, the effect of CI on CNS-resident microglial pr...
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#1Udaysankar Chockanathan (UR: University of Rochester)H-Index: 2
#2Emily J. Warner (UR: University of Rochester)
Last. Krishnan PadmanabhanH-Index: 11
view all 5 authors...
While the link between amyloid β (Aβ) accumulation and synaptic degradation in Alzheimer’s disease (AD) is known, the consequences of this pathology on population coding remain unknown. We found that the entropy, a measure of the diversity of network firing patterns, was lower in the dorsal CA1 region in the APP/PS1 mouse model of Aβ pathology, relative to controls, thereby reducing the population’s coding capacity. Our results reveal a network level signature of the deficits Aβ accumulation cau...
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#1Joshua J. Hinkle (UR: University of Rochester)
#2John A. Olschowka (UR: University of Rochester)H-Index: 44
Last. M. Kerry O'Banion (UR: University of Rochester)H-Index: 37
view all 5 authors...
Cranial irradiation is the main therapeutic treatment for primary and metastatic malignancies in the brain. However, cranial radiation therapy produces long-term impairment in memory, information processing, and attention that contribute to a decline in quality of life. The hippocampal neural network is fundamental for proper storage and retrieval of episodic and spatial memories, suggesting that hippocampal signaling dysfunction could be responsible for the progressive memory deficits observed ...
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#1Fatima Rivera-Escalera (UR: University of Rochester)H-Index: 3
#2Jonathan J. Pinney (UR: University of Rochester)H-Index: 1
Last. M. Kerry O'Banion (UR: University of Rochester)H-Index: 37
view all 8 authors...
Neuroinflammation is thought to contribute to the pathogenesis of Alzheimer’s disease (AD), yet numerous studies have demonstrated a beneficial role for neuroinflammation in amyloid plaque clearance. We have previously shown that sustained expression of IL-1β in the hippocampus of APP/PS1 mice decreases amyloid plaque burden independent of recruited CCR2+ myeloid cells, suggesting resident microglia as the main phagocytic effectors of IL-1β-induced plaque clearance. To date, however, the mechani...
1 CitationsSource
#1Katrina Jew (UR: University of Rochester)H-Index: 2
#2Denise Herr (UR: University of Rochester)H-Index: 1
Last. Alison Elder (UR: University of Rochester)H-Index: 37
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A growing body of epidemiological literature indicates that particulate matter (PM) air pollution exposure is associated with elevated Alzheimer’s disease (AD) risk and may exacerbate AD-related cognitive decline. Of concern is exposure to the ultrafine PM (UFP) fraction (≤100 nm), which deposits efficiently throughout the respiratory tract, has higher rates of translocation to secondary organs, like brain, and may induce inflammatory changes. We, therefore, hypothesize that exposure to UFPs wil...
1 CitationsSource
#1Layne Dylla (URMC: University of Rochester Medical Center)H-Index: 3
#2David H. Adler (URMC: University of Rochester Medical Center)H-Index: 8
Last. Jeremy T. Cushman (URMC: University of Rochester Medical Center)H-Index: 1
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Abstract Objective Brief early administration of supplemental oxygen (sO2) to create hyperoxia may increase oxygenation to penumbral tissue and improve stroke outcomes. Hyperoxia may also result in respiratory compromise and vasoconstriction leading to worse outcomes. This study examines the effects of prehospital sO2 in stroke. Methods This is a retrospective analysis of adult acute stroke patients (aged ≥18years) presenting via EMS to an academic Comprehensive Stroke Center between January 1, ...
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#1Bin Liu (Harvard University)H-Index: 43
#2Robert G. Hinshaw (MIT: Massachusetts Institute of Technology)H-Index: 1
Last. Cynthia A. Lemere (Harvard University)H-Index: 57
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Space travel will expose people to high-energy, heavy particle radiation, and the cognitive deficits induced by this exposure are not well understood. To investigate the short-term effects of space radiation, we irradiated 4-month-old Alzheimer’s disease (AD)-like transgenic (Tg) mice and wildtype (WT) littermates with a single, whole-body dose of 10 or 50 cGy 56Fe ions (1 GeV/u) at Brookhaven National Laboratory. At ~1.5 months post irradiation, behavioural testing showed sex-, genotype-, and d...
2 CitationsSource
#1Dawling A. Dionisio-Santos (UR: University of Rochester)H-Index: 1
#2John A. Olschowka (UR: University of Rochester)H-Index: 44
Last. M. Kerry O'Banion (UR: University of Rochester)H-Index: 37
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Neuroinflammation is considered one of the cardinal features of Alzheimer’s disease (AD). Neuritic plaques composed of amyloid β and neurofibrillary tangle-laden neurons are surrounded by reactive astrocytes and microglia. Exposure of microglia, the resident myeloid cell of the CNS, to amyloid β causes these cells to acquire an inflammatory phenotype. While these reactive microglia are important to contain and phagocytose amyloid plaques, their activated phenotype impacts CNS homeostasis. In rod...
7 CitationsSource
#1Sage Begolly (UR: University of Rochester)H-Index: 2
#2John A. Olschowka (UR: University of Rochester)H-Index: 44
Last. M. Kerry O'Banion (UR: University of Rochester)H-Index: 37
view all 5 authors...
2 CitationsSource
#1Elisa H. Fleming (UTMB: University of Texas Medical Branch)H-Index: 4
#2Eliana E. Ochoa (UTMB: University of Texas Medical Branch)H-Index: 2
Last. Norbert J. Roberts (UTMB: University of Texas Medical Branch)H-Index: 13
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Both respiratory syncytial virus (RSV) and influenza A virus (IAV) may infect human peripheral blood mononuclear leukocytes (PBMC) during the immune response to viral challenge as the cells are recruited to the respiratory tract. The current studies demonstrated differences in PBMC responses to the two viruses very early after exposure, including reduced fos protein and CD69 expression and IL-2 production by RSV-exposed T lymphocytes. Exposure to RSV resulted in reduced lymphocyte proliferation ...
6 CitationsSource
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