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M. Kerry O'Banion
University of Rochester
52Publications
27H-index
3,021Citations
Publications 52
Newest
Published on Apr 5, 2019in Journal of Neuroinflammation5.70
Dawling A. Dionisio-Santos (UR: University of Rochester), John A. Olschowka44
Estimated H-index: 44
(UR: University of Rochester),
M. Kerry O’Banion21
Estimated H-index: 21
(UR: University of Rochester)
Neuroinflammation is considered one of the cardinal features of Alzheimer’s disease (AD). Neuritic plaques composed of amyloid β and neurofibrillary tangle-laden neurons are surrounded by reactive astrocytes and microglia. Exposure of microglia, the resident myeloid cell of the CNS, to amyloid β causes these cells to acquire an inflammatory phenotype. While these reactive microglia are important to contain and phagocytose amyloid plaques, their activated phenotype impacts CNS homeostasis. In rod...
Published on Dec 1, 2019in Scientific Reports4.01
Bin Liu3
Estimated H-index: 3
(Harvard University),
Robert G. Hinshaw (MIT: Massachusetts Institute of Technology)+ 17 AuthorsPeter Holton1
Estimated H-index: 1
(Harvard University)
Space travel will expose people to high-energy, heavy particle radiation, and the cognitive deficits induced by this exposure are not well understood. To investigate the short-term effects of space radiation, we irradiated 4-month-old Alzheimer’s disease (AD)-like transgenic (Tg) mice and wildtype (WT) littermates with a single, whole-body dose of 10 or 50 cGy 56Fe ions (1 GeV/u) at Brookhaven National Laboratory. At ~1.5 months post irradiation, behavioural testing showed sex-, genotype-, and d...
Published on Apr 1, 2018in Glia5.83
Sage Begolly2
Estimated H-index: 2
(UR: University of Rochester),
John A. Olschowka44
Estimated H-index: 44
(UR: University of Rochester)
+ 2 AuthorsM. Kerry O'Banion27
Estimated H-index: 27
(UR: University of Rochester)
Published on Jan 1, 2018in Journal of Medical Virology2.05
Elisa H. Fleming4
Estimated H-index: 4
(UTMB: University of Texas Medical Branch),
Eliana E. Ochoa2
Estimated H-index: 2
(UTMB: University of Texas Medical Branch)
+ 3 AuthorsNorbert J. Roberts13
Estimated H-index: 13
(UTMB: University of Texas Medical Branch)
Both respiratory syncytial virus (RSV) and influenza A virus (IAV) may infect human peripheral blood mononuclear leukocytes (PBMC) during the immune response to viral challenge as the cells are recruited to the respiratory tract. The current studies demonstrated differences in PBMC responses to the two viruses very early after exposure, including reduced fos protein and CD69 expression and IL-2 production by RSV-exposed T lymphocytes. Exposure to RSV resulted in reduced lymphocyte proliferation ...
Published on Dec 1, 2016in Journal of Neuroinflammation5.70
Michael J. Moravan7
Estimated H-index: 7
(UR: University of Rochester),
John A. Olschowka44
Estimated H-index: 44
(UR: University of Rochester)
+ 1 AuthorsM. Kerry O’Banion21
Estimated H-index: 21
(UR: University of Rochester)
Background Cranial radiotherapy is used to treat tumors of the central nervous system (CNS), as well as non-neoplastic conditions such as arterio-venous malformations; however, its use is limited by the tolerance of adjacent normal CNS tissue, which can lead to devastating long-term sequelae for patients. Despite decades of research, the underlying mechanisms by which radiation induces CNS tissue injury remain unclear. Neuroinflammation and immune cell infiltration are a recognized component of ...
Published on Dec 1, 2016in Radiation Research2.78
Tara B. Sweet1
Estimated H-index: 1
(UR: University of Rochester),
Sean D. Hurley8
Estimated H-index: 8
(UR: University of Rochester)
+ 3 AuthorsM. Kerry O'Banion27
Estimated H-index: 27
(UR: University of Rochester)
Understanding the dose-toxicity profile of radiation is critical when evaluating potential health risks associated with natural and man-made sources in our environment. The purpose of this study was to evaluate the effects of low-dose whole-body high-energy charged (HZE) iron (Fe) ions and low-energy gamma exposure on proliferation and differentiation of adult-born neurons within the dentate gyrus of the hippocampus, cells deemed to play a critical role in memory regulation. To determine the dos...
Sage Begolly2
Estimated H-index: 2
(UR: University of Rochester),
Peter Shrager36
Estimated H-index: 36
(UR: University of Rochester)
+ 2 AuthorsM. Kerry O'Banion27
Estimated H-index: 27
(UR: University of Rochester)
Purpose To determine the late effects of fractionated versus single-dose cranial radiation on murine white matter. Methods and Materials Mice were exposed to 0 Gy, 6 × 6 Gy, or 1 × 20 Gy cranial irradiation at 10 to 12 weeks of age. Endpoints were assessed through 18 months from exposure using immunohistochemistry, electron microscopy, and electrophysiology. Results Weight gain was temporarily reduced after irradiation; greater loss was seen after single versus fractionated doses. Oligodendrocyt...
Published on Sep 1, 2016in Journal of Neurochemistry4.87
Katrin Andreasson35
Estimated H-index: 35
(Stanford University),
Adam D. Bachstetter32
Estimated H-index: 32
(UK: University of Kentucky)
+ 18 AuthorsMarina A. Lynch60
Estimated H-index: 60
(Trinity College, Dublin)
Abstract Neuroinflammation is critically involved in numerous neurodegenerative diseases, and key signaling steps of innate immune activation hence represent promising therapeutic targets. This mini review series originated from the 4th Venusberg Meeting on Neuroinflammation held in Bonn, Germany, 7-9th May 2015, presenting updates on innate immunity in acute brain injury and chronic neurodegenerative disorders, such as traumatic brain injury and Alzheimer disease, on the role of astrocytes and ...
Published on Jul 1, 2016in Radiation Research2.78
Jacqueline P. Williams33
Estimated H-index: 33
(URMC: University of Rochester Medical Center),
Laura M. Calvi26
Estimated H-index: 26
(URMC: University of Rochester Medical Center)
+ 3 AuthorsEdward J. Puzas10
Estimated H-index: 10
(URMC: University of Rochester Medical Center)
Published on Jan 1, 2016
David L. Felten2
Estimated H-index: 2
,
M. Kerry O'Banion27
Estimated H-index: 27
(UR: University of Rochester),
Mary Summo Maida1
Estimated H-index: 1
(UR: University of Rochester)
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