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Lucas Maillette de Buy Wenniger
University of Amsterdam
28Publications
14H-index
837Citations
Publications 28
Newest
Published on Aug 1, 2016in Hepatology14.97
Marieke E. Doorenspleet12
Estimated H-index: 12
,
Lowiek M. Hubers7
Estimated H-index: 7
+ 10 AuthorsThomas M. van Gulik62
Estimated H-index: 62
Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) of the biliary tree and pancreas is difficult to distinguish from sclerosing cholangitis and biliary/pancreatic malignancies (CA). An accurate noninvasive test for diagnosis and monitoring of disease activity is lacking. We demonstrate that dominant IgG4(+) B-cell receptor (BCR) clones determined by next-generation sequencing accurately distinguish patients with IgG4-associated cholangitis/autoimmune pancreatitis (n = 34) from those with primary...
Published on Oct 1, 2015in Pancreas2.67
Jorie Buijs5
Estimated H-index: 5
,
Djuna L. Cahen17
Estimated H-index: 17
+ 10 AuthorsMenno A. Brink17
Estimated H-index: 17
textabstractObjective To evaluate the long-term outcome of autoimmune pancreatitis. Methods Patients with at least 2 years of follow-up were included. Information was collected regarding disease characteristics, treatment outcome, diagnosed malignancies, and mortality. In addition, pancreatic function and quality of life were assessed prospectively. Results 107 patients were included (87% men, 90% with type 1), with a median follow-up of 74 (interquartile range, 49-108) months. One third was ope...
Published on Jun 1, 2015in Clinical Reviews in Allergy & Immunology7.33
Lowiek M. Hubers7
Estimated H-index: 7
(UvA: University of Amsterdam),
Lucas Maillette de Buy Wenniger14
Estimated H-index: 14
(UvA: University of Amsterdam)
+ 8 AuthorsVries de N. K47
Estimated H-index: 47
(UvA: University of Amsterdam)
IgG4-associated cholangitis (IAC) is a major manifestation of immunoglobulin G4-related disease (IgG4-RD), an inflammatory multiorgan disorder of unknown cause. IAC and autoimmune pancreatitis (AIP) may mimic sclerosing cholangitis, cholangiocarcinoma, or pancreatic carcinoma. Typically, elderly male patients present with abdominal discomfort, weight loss, jaundice, and itch. At present, no accurate diagnostic test for IAC and IgG4-RD is at hand, often causing significant diagnostic delay. Serum...
Published on May 27, 2015in Digestive Diseases2.91
Lucas Maillette de Buy Wenniger14
Estimated H-index: 14
,
Simon Hohenester12
Estimated H-index: 12
+ 3 AuthorsUlrich Beuers55
Estimated H-index: 55
Background: Destruction of cholangiocytes is the hallmark of chronic cholangiopathies such as primary biliary cirrhosis. Under physiologic conditions, cholangiocytes display a striking resistance to the high, millimolar concentrations of toxic bile salts present in bile. We recently showed that a ‘biliary HCO3- umbrella', i.e. apical cholangiocellular HCO3- secretion, prevents cholangiotoxicity of bile acids, and speculated on a role for extracellular membrane-bound glycans in the stabilization ...
Published on May 1, 2015in Current Opinion in Gastroenterology2.74
Lucas Maillette de Buy Wenniger14
Estimated H-index: 14
,
Ulrich Beuers55
Estimated H-index: 55
The clinical spectrum of immunoglobulin G4-related disease (IgG4-RD) is diverse and the disease may affect multiple organ systems. The pancreatobiliary tract probably is the clinically most important localization of the disease but diagnosing IgG4-related cholangiopathy (synonym: IgG4-associated cholangitis) or autoimmune pancreatitis is often challenging. This review summarizes the current best practice in diagnosing and treating IgG4-related cholangiopathy and recent advances in our understand...
Published on Jan 1, 2015in Digestive Diseases2.91
L. Muratori43
Estimated H-index: 43
,
Gaia Deleonardi5
Estimated H-index: 5
+ 69 AuthorsJohannes Herkel1
Estimated H-index: 1
Published on Jan 1, 2015in Digestive Diseases2.91
Ulrich Beuers55
Estimated H-index: 55
,
Lowiek M. Hubers7
Estimated H-index: 7
+ 6 AuthorsVries de N. K47
Estimated H-index: 47
IgG4-associated cholangitis (IAC) is an inflammatory disorder of the biliary tract representing a major manifestation of IgG4-related disease (IgG4-RD) often with elevation of serum IgG4 levels, infiltration of IgG4+ plasma cells in the affected tissue and good response to immunosuppressive treatment. Its first description may go back to 150 years ago. The clinical presentation of IAC is often misleading, mimicking other biliary diseases such as primary sclerosing cholangitis (PSC) or cholangioc...
Published on May 1, 2014in Gastroenterology19.23
Jorie Buijs5
Estimated H-index: 5
,
Djuna L. Cahen17
Estimated H-index: 17
+ 10 AuthorsMenno A. Brink17
Estimated H-index: 17
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