Match!
Eleni N. Tsakiri
National and Kapodistrian University of Athens
21Publications
7H-index
277Citations
Publications 21
Newest
#1Eleni N. Tsakiri (UoA: National and Kapodistrian University of Athens)H-Index: 7
#2Sentiljana Gumeni (UoA: National and Kapodistrian University of Athens)H-Index: 6
Last.Ιωάννης Π. Τρουγκάκος (UoA: National and Kapodistrian University of Athens)H-Index: 32
view all 10 authors...
ABSTRACTThe ubiquitin-proteasome pathway (UPP) is central to proteostasis network (PN) functionality and proteome quality control. Yet, the functional implication of the UPP in tissue homeodynamics...
7 CitationsSource
#1Maria Manola (UoA: National and Kapodistrian University of Athens)H-Index: 1
#2Eleni N. Tsakiri (UoA: National and Kapodistrian University of Athens)H-Index: 7
Last.Ioannis P. Trougakos (UoA: National and Kapodistrian University of Athens)H-Index: 4
view all 3 authors...
Being an assembly of highly sophisticated protein machines, cells depend heavily on proteostatic modules functionality and on adequate supply of energetic molecules for maintaining proteome stability. Yet, our understanding of the adaptations induced by multigenerational proteotoxic stress is limited. We report here that multigenerational (>80 generations) proteotoxic stress in OregonR flies induced by constant exposure to developmentally nonlethal doses of the proteasome inhibitor bortezomib (B...
1 CitationsSource
#1Sentiljana Gumeni (UoA: National and Kapodistrian University of Athens)H-Index: 6
#2Zoi Evangelakou (UoA: National and Kapodistrian University of Athens)H-Index: 1
Last.Ιωάννης Π. Τρουγκάκος (UoA: National and Kapodistrian University of Athens)H-Index: 32
view all 5 authors...
Abstract Being an assembly of protein machines, cells depend on adequate supply of energetic molecules for retaining their homeodynamics. Consequently, mitochondria functionality is ensured by quality control systems and mitochondrial dynamics (fusion/fission). Similarly, proteome stability is maintained by the machineries of the proteostasis network. We report here that reduced mitochondrial fusion rates in Drosophila caused developmental lethality or if induced in the adult accelerated aging. ...
1 CitationsSource
#1Theodora Nikou (UoA: National and Kapodistrian University of Athens)H-Index: 3
#2Vasiliki Liaki (UoA: National and Kapodistrian University of Athens)H-Index: 1
Last.Leandros Skaltsounis (UoA: National and Kapodistrian University of Athens)H-Index: 17
view all 10 authors...
Abstract Olive oil is widely accepted as a superior edible oil. Great attention has been given lately to olive oil polyphenols which are linked to significant health beneficial effects. Towards a survey of Greek olive oil focusing on polyphenols, representative extra virgin olive oils (EVOOs) from the main producing areas of the country and the same harvesting period have been collected and analyzed. Significant differences and interesting correlations have been identified connecting certain pol...
3 CitationsSource
#1Eleni N. Tsakiri (UoA: National and Kapodistrian University of Athens)H-Index: 7
#2Sentiljana Gumeni (UoA: National and Kapodistrian University of Athens)H-Index: 6
Last.Ioannis P. Trougakos (UoA: National and Kapodistrian University of Athens)H-Index: 4
view all 10 authors...
Metazoans viability depends on their ability to regulate metabolic processes and also to respond to harmful challenges by mounting anti-stress responses; these adaptations were fundamental forces during evolution. Central to anti-stress responses are a number of short-lived transcription factors that by functioning as stress sensors mobilize genomic responses aiming to eliminate stressors. We show here that increased expression of nuclear factor erythroid 2-related factor (Nrf2) in Drosophila ac...
6 CitationsSource
#1Eleni N. Tsakiri (UoA: National and Kapodistrian University of Athens)H-Index: 7
#2Sentiljana Gumeni (UoA: National and Kapodistrian University of Athens)H-Index: 6
Last.Ioannis P. Trougakos (UoA: National and Kapodistrian University of Athens)H-Index: 4
view all 11 authors...
Metazoans respond to harmful challenges by mounting anti-stress responses. This adaptation along with the evolvement of metabolic networks, were fundamental forces during evolution. Central to anti-stress responses are a number of short-lived transcription factors that by functioning as stress sensors mobilize genomic responses aiming to eliminate stressors and restore tissue homeodynamics. We have found that increased expression of nuclear factor erythroid 2-related factor (Nrf2) in Drosophila ...
Source
#1Christina Cheimonidi (UoA: National and Kapodistrian University of Athens)H-Index: 2
#2Pinelopi Samara (UoA: National and Kapodistrian University of Athens)H-Index: 7
Last.Ιωάννης Π. Τρουγκάκος (UoA: National and Kapodistrian University of Athens)H-Index: 32
view all 17 authors...
Abstract Natural products are characterized by extreme structural diversity and thus they offer a unique source for the identification of novel anti-tumor agents. Herein, we report that the herbal substance acteoside being isolated by advanced phytochemical methods from Lippia citriodora leaves showed enhanced cytotoxicity against metastatic tumor cells; acted in synergy with various cytotoxic agents and it sensitized chemoresistant cancer cells. Acteoside was not toxic in physiological cellular...
4 CitationsSource
#1Eleni N. Tsakiri (UoA: National and Kapodistrian University of Athens)H-Index: 7
#2Evangelos Terpos (UoA: National and Kapodistrian University of Athens)H-Index: 46
Last.Ιωάννης Π. Τρουγκάκος (UoA: National and Kapodistrian University of Athens)H-Index: 32
view all 13 authors...
Proteasome inhibitors, e.g. Bortezomib (BTZ) and Carfilzomib (CFZ), have demonstrated clinical efficacy against haematological cancers. Interestingly, several adverse effects are less common, compared to BTZ, in patients treated with CFZ. As the molecular details of these observations remain not well understood we assayed the pathophysiological effects of CFZ vs. BTZ in the Drosophila experimental model. Mass Spectrometry analyses showed that neither CFZ nor BTZ are hydrolysed in flies’ tissues,...
4 CitationsSource
#1Sentiljana GumeniH-Index: 6
#2Eleni N. TsakiriH-Index: 7
view all 9 authors...
Source
#1Sentiljana GumeniH-Index: 6
#2Eleni N. TsakiriH-Index: 7
view all 9 authors...
Source
123