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Meera Shanmuganathan
McMaster University
12Publications
4H-index
71Citations
Publications 12
Newest
#1Nadine WellingtonH-Index: 1
Last.Philip Britz-McKibbinH-Index: 26
view all 11 authors...
A large body of evidence has linked unhealthy eating patterns with an alarming increase in obesity and chronic disease worldwide. However, existing methods of assessing dietary intake in nutritional epidemiology rely on food frequency questionnaires or dietary records that are prone to bias and selective reporting. Herein, metabolic phenotyping was performed on 42 healthy participants from the Diet and Gene Intervention (DIGEST) pilot study, a parallel two-arm randomized clinical trial that prov...
3 CitationsSource
#1Meera Shanmuganathan (McMaster University)H-Index: 4
#2Philip Britz-McKibbin (McMaster University)H-Index: 26
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#1Meera Shanmuganathan (McMaster University)H-Index: 4
#2Sabrina Macklai (McMaster University)
Last.Philip Britz-McKibbin (McMaster University)H-Index: 26
view all 8 authors...
New analytical methods are urgently needed to enable high-throughput, yet comprehensive drug screening, given an alarming opioid and prescription drug crisis in public health. Conventional urine drug testing based on a two-tier immunoassay screen followed by a gas chromatography-tandem mass spectrometry (GC-MS/MS) or liquid chromatography-tandem mass spectrometry (LC-MS/MS) method are expensive and prone to bias while being limited to targeted panels of known drugs of abuse (DoA). Herein, we out...
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#1Biban Gill (McMaster University)H-Index: 1
#2Alicia Mell (McMaster University)H-Index: 1
Last.Philip Britz-McKibbin (McMaster University)H-Index: 26
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Urinary 1-hydroxypyrene (OH-Pyr) is widely used for biomonitoring human exposures to polycyclic aromatic hydrocarbons (PAHs) from air pollution and tobacco smoke. However, there have been few rigorous validation studies reported to ensure reliable OH-Pyr determination for occupational health and risk assessment. Herein, we report an inter-laboratory method comparison for urinary OH-Pyr when using gas chromatography-high-resolution mass spectrometry (GC-HRMS) and liquid chromatography-tandem mass...
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#1Jennifer Wild (McMaster University)H-Index: 1
#2Meera Shanmuganathan (McMaster University)H-Index: 4
Last.Philip Britz-McKibbin (McMaster University)H-Index: 26
view all 5 authors...
Management of phenylketonuria (PKU) requires lifelong restriction of phenylalanine (Phe) intake using specialized medical foods to prevent neurocognitive impairment in affected patients. However, dietary adherence is challenging to maintain while ensuring adequate nutrition, which can lead to sub-optimal clinical outcomes. Metabolomics offers a systematic approach to identify new biomarkers of disease progression in PKU when using urine as a surrogate for blood specimens that is more accurate th...
1 CitationsSource
#1Meera Shanmuganathan (McMaster University)H-Index: 4
#2Philip Britz-McKibbin (McMaster University)H-Index: 26
1 CitationsSource
#2Zi-Feng Zhang (HIT: Harbin Institute of Technology)H-Index: 16
Last.Christopher H. MarvinH-Index: 18
view all 7 authors...
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#1Christian Wenz (Agilent Technologies)H-Index: 8
#2Coral BarbasH-Index: 45
Last.SungAe Suhr Park (Amgen)H-Index: 5
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A collaborative study on the robustness and portability of a capillary electrophoresis-mass spectrometry method for peptide mapping was performed by an international team, consisting of 13 independent laboratories from academia and industry. All participants used the same batch of samples, reagents and coated capillaries to run their assays, whereas they utilized the capillary electrophoresis-mass spectrometry equipment available in their laboratories. The equipment used varied in model, type an...
20 CitationsSource
#1Meera Shanmuganathan (McMaster University)H-Index: 4
#2Philip Britz-McKibbin (McMaster University)H-Index: 26
Last.Osama Y. Al-Dirbashi (Children's Hospital of Eastern Ontario)H-Index: 22
view all 3 authors...
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#1Meera Shanmuganathan (McMaster University)H-Index: 4
#2Philip Britz-McKibbin (McMaster University)H-Index: 26
Abstract High quality assays are needed in drug discovery to reduce the high attrition rate of lead compounds during primary screening. Capillary electrophoresis (CE) represents a versatile micro-separation technique for resolution of enzyme-catalyzed reactions, including substrate(s), product(s), cofactor(s) and their stereoisomers, which is needed for reliable characterization of biomolecular interactions in free solution. This review article provides a critical overview of new advances in CE ...
25 CitationsSource
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