Salim Yusuf Mb Bs DPhil Frcpc
Publications 1658
#1John Ferguson (National University of Ireland, Galway)H-Index: 8
#2Neil O’Leary (National University of Ireland, Galway)H-Index: 2
Last.Martin O'Donnell (National University of Ireland, Galway)H-Index: 54
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Background Population attributable fractions (PAF) measure the proportion of disease prevalence that would be avoided in a hypothetical population, similar to the population of interest, but where a particular risk factor is eliminated. They are extensively used in epidemiology to quantify and compare disease burden due to various risk factors, and directly influence public policy regarding possible health interventions. In contrast to individual specific metrics such as relative risks and odds ...
#1John W. Eikelboom (Population Health Research Institute)H-Index: 93
#2Stuart J. Connolly (Population Health Research Institute)H-Index: 56
Last.Salim Yusuf Mb Bs DPhil Frcpc (Population Health Research Institute)H-Index: 214
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Background: Patients treated with antithrombotic drugs are at risk of bleeding. Bleeding may be the first manifestation of underlying cancer. Methods: We examined new cancers diagnosed in relation ...
1 CitationsSource
#1Lukas Aguirre Dávila (MHH: Hannover Medical School)H-Index: 3
#2Kristina Weber (MHH: Hannover Medical School)H-Index: 5
Last.Armin Koch (MHH: Hannover Medical School)H-Index: 26
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3 CitationsSource
#1Rajnish Joshi (AIIMS: All India Institute of Medical Sciences)H-Index: 8
#2Twinkle Agrawal (St. John's Medical College)H-Index: 3
Last.Salim Yusuf Mb Bs DPhil Frcpc (Population Health Research Institute)H-Index: 214
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Abstract Background There is a need to identify and test low cost approaches for cardiovascular disease (CVD) risk reduction that can enable health systems to achieve such a strategy. Objective Community health workers (CHWs) are an integral part of health-care delivery system in lower income countries. Our aim was to assess impact of CHW based interventions in reducing CVD risk factors in rural households in India. Methods We performed an open-label cluster-randomized trial in 28 villages in 3 ...
1 CitationsSource
#1Jon-David Schwalm (Population Health Research Institute)H-Index: 13
#2Tara McCready (Population Health Research Institute)H-Index: 7
Last.Salim Yusuf Mb Bs DPhil Frcpc (McMaster University)H-Index: 214
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Summary Background Hypertension is the leading cause of cardiovascular disease globally. Despite proven benefits, hypertension control is poor. We hypothesised that a comprehensive approach to lowering blood pressure and other risk factors, informed by detailed analysis of local barriers, would be superior to usual care in individuals with poorly controlled or newly diagnosed hypertension. We tested whether a model of care involving non-physician health workers (NPHWs), primary care physicians, ...
7 CitationsSource
#1Sonia S. Anand (McMaster University)H-Index: 76
#2Jack V. Tu (U of T: University of Toronto)H-Index: 80
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#1Kanjana S. Perera (Population Health Research Institute)H-Index: 5
#2Kelvin K.H. Ng (Population Health Research Institute)H-Index: 2
Last.Robert G. Hart (Population Health Research Institute)H-Index: 83
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Importance The COMPASS (Cardiovascular Outcomes for People Using Anticoagulation Strategies) randomized clinical trial was stopped early owing to the efficacy of low-dose rivaroxaban plus aspirin in preventing major cardiovascular events. The main reason for early trial termination was the effect of combination therapy on reducing ischemic strokes. Objective To analyze the association between low-dose rivaroxaban with or without aspirin and different ischemic stroke subtypes. Design, Setting, an...
#1Salim Yusuf Mb Bs DPhil Frcpc (Population Health Research Institute)H-Index: 214
#2Philip Joseph (Population Health Research Institute)H-Index: 17
Last.Gilles Dagenais (Laval University)H-Index: 31
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Summary Background Global estimates of the effect of common modifiable risk factors on cardiovascular disease and mortality are largely based on data from separate studies, using different methodologies. The Prospective Urban Rural Epidemiology (PURE) study overcomes these limitations by using similar methods to prospectively measure the effect of modifiable risk factors on cardiovascular disease and mortality across 21 countries (spanning five continents) grouped by different economic levels. M...
4 CitationsSource
#1Paul Moayyedi (Population Health Research Institute)H-Index: 3
#2John W. Eikelboom (Population Health Research Institute)H-Index: 93
Last.Salim Yusuf Mb Bs DPhil Frcpc (Population Health Research Institute)H-Index: 214
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Background & Aims Proton pump inhibitors (PPIs) are effective at treating acid-related disorders. These drugs are well tolerated in the short term, but long-term treatment was associated with adverse events in observational studies. We aimed to confirm these findings in an adequately powered randomized trial. Methods We performed a 3 × 2 partial factorial double-blind trial of 17,598 participants with stable cardiovascular disease and peripheral artery disease randomly assigned to groups given p...
9 CitationsSource
#1Marie Pigeyre (McMaster University)H-Index: 17
#2Jennifer Sjaarda (McMaster University)H-Index: 3
Last.Guillaume ParéH-Index: 52
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OBJECTIVE Observations of a metabolically unhealthy normal weight phenotype suggest that a lack of favorable adiposity contributes to an increased risk of type 2 diabetes. We aimed to identify causal blood biomarkers linking favorable adiposity with type 2 diabetes risk for use in cardiometabolic risk assessments. RESEARCH DESIGN AND METHODS A weighted polygenic risk score (PRS) underpinning metabolically favorable adiposity was validated in the UK Biobank (n = 341,872) and the Outcome Reduction...