Donna Vermes
Columbia University
PsychiatryPsychologyRandomized controlled trialPlaceboClinical psychology
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Publications 19
4 CitationsSource
#1Franklin R. Schneier (Columbia University)H-Index: 47
#2Raphael Campeas (Columbia University)H-Index: 30
Last. Melanie M. Wall (Columbia University)H-Index: 65
view all 9 authors...
Background Combined treatment with a selective serotonin reuptake inhibitor (SSRI) plus mirtazapine has shown superior efficacy in some studies of depression but has not been studied in posttraumatic stress disorder (PTSD). This study aimed to assess acceptability of combined sertraline plus mirtazapine treatment for PTSD and to estimate its effect size relative to sertraline plus placebo.
20 CitationsSource
#1Carolyn I. Rodriguez (Columbia University)H-Index: 18
#2Lawrence S. Kegeles (Columbia University)H-Index: 46
Last. Helen Blair Simpson (Columbia University)H-Index: 41
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Abstract We previously reported the rapid and robust clinical effects of ketamine versus saline infusions in a proof-of-concept crossover trial in unmedicated adults with obsessive-compulsive disorder (OCD). This study examined the concurrent neurochemical effects of ketamine versus saline infusions using proton magnetic resonance spectroscopy ( 1 H MRS) during the clinical proof-of-concept crossover trial. Levels of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and the excitato...
16 CitationsSource
#1Elizabeth A. Hembree (UPenn: University of Pennsylvania)H-Index: 115
#2Helen Blair Simpson (Columbia University)H-Index: 41
Last. Monnica T. Williams (University of Louisville)H-Index: 20
view all 18 authors...
Objective To compare outcomes after six-month maintenance treatment of adults diagnosed with OCD based on DSM IV criteria who responded to acute treatment with serotonin reuptake inhibitors (SRIs) augmented by exposure therapy (EX/RP) or risperidone.
8 CitationsSource
#1Miren IzaH-Index: 7
#2Mark OlfsonH-Index: 94
Last. Carlos BlancoH-Index: 75
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BACKGROUND: Despite the high prevalence of anxiety disorders and the demonstrated efficacy of their treatment, most individuals with anxiety disorders never utilize mental health services. OBJECTIVE: To identify predictors of treatment-seeking for DSM-IV anxiety disorders from a range of sociodemographic factors and comorbid mental disorders. DESIGN: Survival analysis with time-varying covariates was performed using data from the National Epidemiologic Survey on Alcohol and Related Conditions (N...
16 CitationsSource
#1Carolyn I. Rodriguez (Columbia University)H-Index: 18
#2Lawrence S. Kegeles (Columbia University)H-Index: 46
Last. Helen Blair Simpson (Columbia University)H-Index: 41
view all 8 authors...
Randomized Controlled Crossover Trial of Ketamine in Obsessive-Compulsive Disorder: Proof-of-Concept
104 CitationsSource
#1Helen Blair Simpson (Columbia University)H-Index: 41
#2Elizabeth A. Hembree (UPenn: University of Pennsylvania)H-Index: 115
Last. Raphael CampeasH-Index: 30
view all 19 authors...
Importance Obsessive-compulsive disorder (OCD) is one of the world’s most disabling illnesses according to the World Health Organization. Serotonin reuptake inhibitors (SRIs) are the only medications approved by the Food and Drug Administration to treat OCD, but few patients achieve minimal symptoms from an SRI alone. In such cases, practice guidelines recommend adding antipsychotics or cognitive-behavioral therapy consisting of exposure and ritual prevention (EX/RP). Objective To compare the ef...
105 CitationsSource
Objective: This article describes the long-term effects of augmenting serotonin reuptake inhibitors (SRIs) with exposure and ritual prevention or stress management training in patients with DSM-IV obsessive-compulsive disorder (OCD). Method: Between November 2000 and November 2006, 111 OCD patients from 2 academic outpatient centers with partial SRI response were randomized to the addition of exposure and ritual prevention or stress management training, delivered twice weekly for 8 weeks (acute ...
17 CitationsSource
#1Carlos BlancoH-Index: 75
#2Richard G. HeimbergH-Index: 91
Last. Michael R. LiebowitzH-Index: 87
view all 12 authors...
Social anxiety disorder (SAD) is a highly prevalent,1–3 chronic and disabling anxiety disorder associated with substantial impairment, decreased quality of life,4–7 and psychiatric comorbidity.8, 9 Although cognitive-behavioral therapy (CBT) and pharmacotherapy are the most efficacious treatments for SAD,10–15 only two-thirds of patients who receive these treatments are considered responders, of which only half are considered remitters.16 Most patients remain symptomatic after initial treatment....
114 CitationsSource
Abstract This study assessed the efficacy, durability, and tolerability of fluoxetine for hypochondriasis, a disorder for which controlled pharmacological trials are scarce. Fifty-seven patients with hypochondriasis were enrolled: 12 discontinued during the placebo run-in, and 45 were randomized to either fluoxetine or placebo for 12 weeks (acute treatment). Responder status was defined as a Clinical Global Impression rating for hypochondriasis of much or very much improved. Secondary outcome me...
30 CitationsSource