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Giulia Mearini
University of Hamburg
36Publications
16H-index
867Citations
Publications 37
Newest
#1Alexander Dutsch (TUM: Technische Universität München)H-Index: 2
#2Paul J. M. Wijnker (UHH: University of Hamburg)
Last.Giulia Mearini (UHH: University of Hamburg)H-Index: 16
view all 13 authors...
Phosphorylation of cardiac myosin-binding protein C (cMyBP-C), encoded by MYBPC3, increases the availability of myosin heads for interaction with actin thus enhancing contraction. cMyBP-C phosphorylation level is lower in septal myectomies of patients with hypertrophic cardiomyopathy (HCM) than in non-failing hearts. Here we compared the effect of phosphomimetic (D282) and wild-type (S282) cMyBP-C gene transfer on the HCM phenotype of engineered heart tissues (EHTs) generated from a mouse model ...
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#1Maksymilian Prondzynski (UHH: University of Hamburg)H-Index: 8
#2Marc D. Lemoine (UHH: University of Hamburg)H-Index: 6
Last.Lucie Carrier (UHH: University of Hamburg)H-Index: 44
view all 25 authors...
3 CitationsSource
#1Jirko Kühnisch (MDC: Max Delbrück Center for Molecular Medicine)H-Index: 14
#2Christopher Herbst (MDC: Max Delbrück Center for Molecular Medicine)
Last.Sabine Klaassen (Humboldt University of Berlin)H-Index: 15
view all 17 authors...
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#1Jirko KühnischH-Index: 14
Last.Sabine KlaassenH-Index: 15
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#1K. Breckwoldt (UHH: University of Hamburg)H-Index: 7
#2David Brenière-Letuffe (UHH: University of Hamburg)
Last.HansenArne (UHH: University of Hamburg)H-Index: 25
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Please note that since the original publication of this paper, the author David Letuffe-Breniere has changed his name to David Breniere-Letuffe
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#1Maksymilian Prondzynski (UHH: University of Hamburg)H-Index: 8
#2Giulia Mearini (UHH: University of Hamburg)H-Index: 16
Last.Lucie Carrier (UHH: University of Hamburg)H-Index: 44
view all 3 authors...
Hypertrophic cardiomyopathy (HCM) is an inherited myocardial disease with an estimated prevalence of 1:200 caused by mutations in sarcomeric proteins. It is associated with hypertrophy of the left ventricle, increased interstitial fibrosis, and diastolic dysfunction for heterozygous mutation carriers. Carriers of double heterozygous, compound heterozygous, and homozygous mutations often display more severe forms of cardiomyopathies, ultimately leading to premature death. So far, there is no cura...
3 CitationsSource
#2Jirko Kühnisch (MDC: Max Delbrück Center for Molecular Medicine)H-Index: 14
Last.Brenda GerullH-Index: 21
view all 11 authors...
2 CitationsSource
#1N Kresin (UHH: University of Hamburg)
#2Sabrina Stücker (UHH: University of Hamburg)H-Index: 1
Last.Felix W. Friedrich (UHH: University of Hamburg)H-Index: 13
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Background. Many forms of hypertrophic cardiomyopathy (HCM) show an increased myofilament Ca2+ sensitivity. This observation has been mainly made in HCM mouse models, myofilament systems, and cardiomyocytes. Studies of multicellular tissues from patients with different HCM-associated gene mutations are scarce. We investigated Ca2+ sensitivity in multicellular cardiac muscle strips of HCM patients. We furthermore evaluated the use of epigallocatechin-3-gallate (EGCg), a Ca2+ desensitizer. Methods...
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#1Marc D. LemoineH-Index: 6
Last.Torsten ChristH-Index: 10
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