Neil Murphy
International Agency for Research on Cancer
European Prospective Investigation into Cancer and NutritionProspective cohort studyHazard ratioColorectal cancerMedicine
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Publications 118
#1Jeroen R. Huyghe (Fred Hutchinson Cancer Research Center)H-Index: 16
#2Tabitha A. Harrison (Fred Hutchinson Cancer Research Center)H-Index: 17
Last. Yi Lin (Fred Hutchinson Cancer Research Center)H-Index: 14
view all 141 authors...
Objective An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical for improving precision prevention, including individualized screening recommendations and the discovery of novel drug targets and repurposable drug candidates for chemoprevention. Known differences in molecular characteristics and environmental risk factors among tumors arising in different locations of the colorectum suggest partly distinct mechanisms of carcinogenesis. The extent to which the cont...
#1Peter T. Campbell (ACS: American Cancer Society)H-Index: 35
#2Yi Lin (Fred Hutchinson Cancer Research Center)H-Index: 14
Last. Jenny Chang-Claude (DKFZ: German Cancer Research Center)H-Index: 92
view all 39 authors...
BACKGROUND: Body mass index (BMI) is a complex phenotype that may interact with genetic variants to influence colorectal cancer risk. METHODS: We tested multiplicative statistical interactions between BMI (per 5 kg.m2) and approximately 2.7 million single nucleotide polymorphisms (SNPs) with colorectal cancer risk among 14,059 colorectal cancer case (53.2% women) and 14,416 control (53.8% women) participants. All analyses were stratified by sex a priori. Statistical methods included two-step (i....
#1A Archambault (NYU: New York University)
#2Yu-Ru Su (Fred Hutchinson Cancer Research Center)H-Index: 2
Last. Richard B. Hayes (NYU: New York University)H-Index: 100
view all 134 authors...
Abstract Background & Aims Early-onset colorectal cancer (CRC, in persons younger than 50 years old) is increasing in incidence; yet, in the absence of a family history of CRC, this population lacks harmonized recommendations for prevention. We aimed to determine whether a polygenic risk score (PRS) developed from 95 CRC-associated common genetic risk variants was associated with risk for early-onset CRC. Methods We studied risk for CRC associated with a weighted PRS in 12,197 participants young...
2 CitationsSource
#1Neil Murphy (IARC: International Agency for Research on Cancer)H-Index: 24
Last. M. J. Gunter (IARC: International Agency for Research on Cancer)H-Index: 40
view all 84 authors...
Abstract Background Aims Human studies examining associations between circulating levels of insulin-like growth factor 1 (IGF1) and insulin-like growth factor binding protein 3 (IGFBP3) and colorectal cancer risk have reported inconsistent results. We conducted complementary serologic and Mendelian randomization (MR) analyses to determine whether alterations in circulating levels of IGF1 or IGFBP3 are associated with colorectal cancer development. Methods Serum levels of IGF1 and other proteins ...
2 CitationsSource
#1Eleanor L. Watts (University of Oxford)H-Index: 1
#2G.K. Fensom (University of Oxford)
Last. Neil Murphy (IARC: International Agency for Research on Cancer)H-Index: 24
view all 14 authors...
Background: Insulin-like growth factor-I (IGF-I) and testosterone have been implicated in prostate cancer aetiology. Using newly available data from a large prospective full-cohort with standardised assays and repeat blood measurements, and genetic data from an international consortium, we aimed to investigate the associations of circulating concentrations of IGF-I, sex hormone-binding globulin (SHBG), total and calculated free testosterone with prostate cancer risk. Patients and methods: For pr...
#1Zhiyu Xia (UW: University of Washington)
#2Yu-Ru Su (Fred Hutchinson Cancer Research Center)
Last. Demetrius Albanes (NIH: National Institutes of Health)H-Index: 100
view all 49 authors...
BACKGROUND: Body mass index (BMI) and diabetes are established risk factors for colorectal cancer (CRC), likely through perturbations in metabolic traits (e.g. insulin resistance and glucose homeostasis). Identification of interactions between variation in genes and these metabolic risk factors may identify novel biologic insights into CRC etiology. METHODS: To improve statistical power and interpretation for gene-environment interaction (G x E) testing, we tested genetic variants that regulate ...
#1Caroline J Bull (UoB: University of Bristol)H-Index: 2
#2Joshua A. Bell (UoB: University of Bristol)H-Index: 15
Last. Stéphane BézieauH-Index: 17
view all 78 authors...
Importance: Evidence on adiposity altering colorectal cancer (CRC) risk differently among men and women, and on metabolic alterations mediating effects of adiposity on CRC, is unclear. Objective: To examine sex− and site−specific associations of adiposity with CRC risk, and whether adiposity−associated metabolites explain associations of adiposity with CRC. Design: Two−sample Mendelian randomization (MR) study. Setting: Genetic variants from expanded genome-wide association studies of body mass ...
#1S. Ghazaleh Dashti (IARC: International Agency for Research on Cancer)H-Index: 3
#2Vivian Viallon (IARC: International Agency for Research on Cancer)H-Index: 2
Last. Neil Murphy (IARC: International Agency for Research on Cancer)H-Index: 24
view all 8 authors...
Mechanisms underlying adiposity-colorectal cancer (CRC) association are incompletely understood. Using UK Biobank data, we investigated the role of C-reactive protein (CRP), hemoglobin-A1c (HbA1c), and (jointly) sex hormone-binding globulin (SHBG) and testosterone, in explaining this association. Total effect of obesity vs normal-weight (based on waist circumference, body mass index, waist-hip ratio) on CRC risk was decomposed into natural direct (NDE) and indirect (NIE) effects using sequential...
#1Neil Murphy (IARC: International Agency for Research on Cancer)H-Index: 24
#2Anika Knüppel (CEU: Cancer Epidemiology Unit)H-Index: 2
Last. Timothy J. Key (CEU: Cancer Epidemiology Unit)H-Index: 121
view all 11 authors...
Background Epidemiological evidence supports a positive association between circulating insulin-like growth factor-1 (IGF-1) concentrations and breast cancer risk, but both the magnitude and causality of this relationship are uncertain. We conducted observational analyses with adjustment for regression dilution bias, and Mendelian randomization (MR) analyses allowed for causal inference. Patients and methods We investigated the associations between circulating IGF-1 concentrations and incident b...
1 CitationsSource
#1Elom K. Aglago (IARC: International Agency for Research on Cancer)H-Index: 2
#2Inge Huybrechts (IARC: International Agency for Research on Cancer)H-Index: 48
Last. M. J. Gunter (IARC: International Agency for Research on Cancer)H-Index: 40
view all 47 authors...
Background & Aims There is an unclear association between intake of fish and long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFAs) and colorectal cancer (CRC). We examined the association between fish consumption, dietary and circulating levels of n-3 LC-PUFAs, and ratio of n-6:n-3 LC-PUFA with CRC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods Dietary intake of fish (total, fatty/oily, lean/white) and n-3 LC-PUFA were estimated by foo...