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Sekiko Taneda
University of Washington
25Publications
11H-index
458Citations
Publications 27
Newest
The progression of immunoglobulin A nephropathy (IgAN) is currently assessed using the Oxford MEST-C score, which uses five indicators (mesangial and endocapillary hypercellularity, segmental sclerosis, interstitial fibrosis/tubular atrophy, and the presence of crescents) but has not yet included any risk factors related to glomerular size. Therefore, we tested whether adding another indicator, maximal glomerular diameter (Max GD), would improve the prognostic ability of this scoring system. The...
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Abstract The 2017 Banff meeting provided specific criteria for the diagnosis of tubulointerstitial changes in chronic active T cell-mediated rejection (CATCR), with an emphasis on inflammation in areas of interstitial fibrosis and tubular atrophy, which was thought to reflect an ongoing T cell-mediated alloimmunity. CATCR is considered to occur as a consequence of persistent or recurrent acute T cell-mediated rejection. Acute T cell-mediated rejection is an acute cytotoxic T-cell reaction to HLA...
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Last.Toshio MochizukiH-Index: 21
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Abstract Light chain proximal tubulopathy is a rare M-proteinemia-related nephropathy. The inclusions composed of light chains in light chain proximal tubulopathy are generally crystalline, and most of them exhibit a rhombic shape. Non-crystalline structures, such as rods or needle shapes, may also be present. In our patient, one of the non-crystalline structures, fibrillary inclusions in the cytoplasm, was observed, as previously reported in only four patients, whose primary disease was either ...
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#1Sekiko TanedaH-Index: 11
#2Kazuho Honda (Showa University)H-Index: 24
Last.Hideaki OdaH-Index: 19
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#2Jun InoH-Index: 4
Last.Toshio MochizukiH-Index: 21
view all 12 authors...
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#1Keisuke SatoH-Index: 1
#2Shiho MakabeH-Index: 2
Last.Toshio MochizukiH-Index: 21
view all 11 authors...
1 CitationsSource
#1Chiari KojimaH-Index: 11
#2Kazuho HondaH-Index: 24
Last.Kosaku NittaH-Index: 38
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A 48-year-old male was admitted to our hospital with nephrotic syndrome. Light-microscopic examination of a renal biopsy specimen showed almost normal glomerular appearance, however, immunofluorescence examination revealed linear and granular IgG deposits on the glomerular basement membrane (GBM), accompanied by slight IgG deposition in the tubular basement membrane (TBM). Further investigation of the IgG subclass and light chain staining revealed that the glomerular deposits were composed of Ig...
2 CitationsSource
#1Sekiko TanedaH-Index: 11
#2Kazuho HondaH-Index: 24
Last.Hideaki OdaH-Index: 19
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Autosomal recessive polycystic kidney disease (ARPKD) is caused by genetic mutations of the gene encoding fibrocystin, and is characterized by the collecting duct cysts and congenital hepatic fibrosis. We report an autopsy-proven case of ARPKD in a 77-year-old male who presented with rapidly progressive renal and liver dysfunction. He had refused hemodialysis, and died 4 months later. At autopsy, both kidneys were enlarged with numerous small cysts throughout the cortex, which were revealed immu...
6 CitationsSource
#1Kenichi AkiyamaH-Index: 2
#2Mitsuyo ItabashiH-Index: 9
Last.Nitta KH-Index: 4
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1 Citations
The present study was designed to elucidate a possible mechanism of hyperglycemia-induced tubular injury and to examine a therapeutic potential of dietary eicosapentaenoic acid (EPA) for the prevention of diabetic kidney disease. Utilizing streptozotocin-induced diabetic mice, the extents of albuminuria and histological injuries were monitored at 2 wk after diabetic induction. Reactive oxygen species (ROS) production, apoptosis, and hypoxia in the kidney were evaluated by immunohistochemistry an...
27 CitationsSource
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