Benoit J. Arsenault
Laval University
Publications 186
#1Roelof A.J. Smit (LUMC: Leiden University Medical Center)H-Index: 9
#2Stella Trompet (LUMC: Leiden University Medical Center)H-Index: 53
Last.Johan Jukema (LUMC: Leiden University Medical Center)H-Index: 109
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It remains unclear whether the increased risk of new-onset type 2 diabetes (T2D) seen in statin users is due to low LDL-C concentrations, or due to the statin-induced proportional change in LDL-C. In addition, genetic instruments have not been proposed before to examine whether liability to T2D might cause greater proportional statin-induced LDL-C lowering. Using summary-level statistics from the Genomic Investigation of Statin Therapy (GIST, nmax = 40,914) and DIAGRAM (nmax = 159,208) consortia...
#1Mickael Rosa (Laval University)H-Index: 2
#2Arnaud Chignon (Laval University)
Last.Patrick Mathieu (Laval University)H-Index: 48
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Growing evidence suggests that inflammation is a significant contributor to different cardiovascular diseases (CVDs). Mendelian randomization (MR) was performed to assess the causal inference between plasma soluble IL6 receptor (sIL6R), a negative regulator of IL6 signaling, and different cardiovascular and immune-related disorders. Cis-MR with multiple instrumental variables showed an inverse association of sIL6R with rheumatoid arthritis, atrial fibrillation, stroke, coronary artery disease, a...
1 CitationsSource
#1Nicolas PerrotH-Index: 3
#2Donato MoschettaH-Index: 2
Last.Benoit J. ArsenaultH-Index: 30
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#1Sébastien Thériault (Laval University)H-Index: 12
#2Christian Dina (University of Nantes)H-Index: 15
Last.Jean-Jacques Schott (University of Nantes)H-Index: 43
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Background: Calcific aortic valve stenosis (CAVS) is a frequent and life-threatening cardiovascular disease for which there is currently no medical treatment available. To date, only 2 genes, LPA a...
#1Ian J. Neeland (UTSW: University of Texas Southwestern Medical Center)H-Index: 23
#2Robert Ross (Queen's University)H-Index: 51
Last.Robert H. Eckel (University of Colorado Denver)H-Index: 97
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Findings from epidemiological studies over the past 30 years have shown that visceral adipose tissue, accurately measured by CT or MRI, is an independent risk marker of cardiovascular and metabolic morbidity and mortality. Emerging evidence also suggests that ectopic fat deposition, including hepatic and epicardial fat, might contribute to increased atherosclerosis and cardiometabolic risk. This joint position statement from the International Atherosclerosis Society and the International Chair o...
4 CitationsSource
#1Kang H. Zheng (UvA: University of Amsterdam)H-Index: 4
#2Benoit J. Arsenault (Laval University)H-Index: 30
Last.S. Matthijs Boekholdt (UvA: University of Amsterdam)H-Index: 53
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Background Apolipoprotein B/apolipoprotein A‐I (apoB/apoA‐I) ratio and lipoprotein(a) (Lp[a]) are associated with aortic valve stenosis (AVS) disease progression. Clinical characteristics such as a...
1 CitationsSource
#1Nicolas Perrot (Laval University)H-Index: 3
#2Sébastien Thériault (Laval University)H-Index: 12
Last.Benoit J. Arsenault (Laval University)H-Index: 30
view all 26 authors...
Importance Genetic variants at theLPAlocus are associated with both calcific aortic valve stenosis (CAVS) and coronary artery disease (CAD). Whether these variants are associated with CAVS in patients with CAD vs those without CAD is unknown. Objective To study the associations ofLPAvariants with CAVS in a cohort of patients undergoing heart surgery andLPAwith CAVS in patients with CAD vs those without CAD and to determine whether first-degree relatives of patients with CAVS and high lipoprotein...